Mycoplasma hominis is an opportunistic microorganism that colonizes the genitourinary tract and causes genitourinary infections.However,pulmonary infections caused by M.hominis have rarely been reported in immunocompe...Mycoplasma hominis is an opportunistic microorganism that colonizes the genitourinary tract and causes genitourinary infections.However,pulmonary infections caused by M.hominis have rarely been reported in immunocompetent individuals.Herein,we report a rare case of an immunocompetent adult male with M.hominis pneumonia who presented with multiple pulmonary nodules that progressed to a cavitary mass with a halo sign.The presence of M.hominis infection was confirmed using multiplex polymerase chain reaction(mPCR)of the bronchoalveolar lavage fluid.The patient demonstrated no response to the initial levofloxacin therapy;however,the symptoms subsequently improved after the administration of moxifloxacin.M.hominis may be an underestimated causative agent of community-acquired pneumonia of unknown etiology in immunocompetent adults,and the involvement of the organism should be especially suspected in sexually active patients.Molecular diagnostic methods,such as mPCR,can be used to identify the etiology of atypical pneumonia.Appropriate antibiotics are crucial for effective treatment.展开更多
Dear Editor,The coronavirus disease 2019(COVID-19)has resulted in more than 66.5 million cases globally in more than 191 countries with overl,529,000 mortalities as of 6 December.Currently,the COVID-19 continued to sp...Dear Editor,The coronavirus disease 2019(COVID-19)has resulted in more than 66.5 million cases globally in more than 191 countries with overl,529,000 mortalities as of 6 December.Currently,the COVID-19 continued to spread around the world,while the duration of antibody lasts and antibody level remained poorly understood,which are primary for safe and effective antiviral treatments and vaccines in the future.In this study,we comprehensively characterized the longitudinal changes of antibodies in recovered patients from 5-7 to 34-42 weeks after symptom onset.展开更多
基金supported by the Top-Notch Project for Youth Training(20QNPY115).
文摘Mycoplasma hominis is an opportunistic microorganism that colonizes the genitourinary tract and causes genitourinary infections.However,pulmonary infections caused by M.hominis have rarely been reported in immunocompetent individuals.Herein,we report a rare case of an immunocompetent adult male with M.hominis pneumonia who presented with multiple pulmonary nodules that progressed to a cavitary mass with a halo sign.The presence of M.hominis infection was confirmed using multiplex polymerase chain reaction(mPCR)of the bronchoalveolar lavage fluid.The patient demonstrated no response to the initial levofloxacin therapy;however,the symptoms subsequently improved after the administration of moxifloxacin.M.hominis may be an underestimated causative agent of community-acquired pneumonia of unknown etiology in immunocompetent adults,and the involvement of the organism should be especially suspected in sexually active patients.Molecular diagnostic methods,such as mPCR,can be used to identify the etiology of atypical pneumonia.Appropriate antibiotics are crucial for effective treatment.
基金This work was supported by the National Key Research and Development Project of China(2020YFC0842200,2020YFA0707801)the Beijing Natural Science Foundation(No.7202196)+3 种基金Beijing Nova Program(No.xx2018052)Science and Technology Development Plan Project of Jilin Province(20200901007SF)Cheng-Feng Qin was supported by the National Science Fund for Distinguished Young Scholar(No.81925025)the Innovation Fund for Medical Sciences(No.2019RU040)from the Chinese Academy of Medical Sciences(CAMS).
文摘Dear Editor,The coronavirus disease 2019(COVID-19)has resulted in more than 66.5 million cases globally in more than 191 countries with overl,529,000 mortalities as of 6 December.Currently,the COVID-19 continued to spread around the world,while the duration of antibody lasts and antibody level remained poorly understood,which are primary for safe and effective antiviral treatments and vaccines in the future.In this study,we comprehensively characterized the longitudinal changes of antibodies in recovered patients from 5-7 to 34-42 weeks after symptom onset.
