An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields...An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields and excellent regioselectivity. Functionalizations of the indole products were carried out affording highly valuable and versatile compounds. The indolization protocol was studied as a fundamental step for the preparation of pravadoline and 1-butyl-3-(1-naphthoyl)indole (JWH-073), bioactive molecules showing antinociceptic properties.展开更多
Modulational instabilities in nonlinear optics are the fundamental processes that cause the transition from uniform states to structures in extended systems.Quite counterintuitively,such processes can be enhanced rath...Modulational instabilities in nonlinear optics are the fundamental processes that cause the transition from uniform states to structures in extended systems.Quite counterintuitively,such processes can be enhanced rather than inhibited when spectrally asymmetric losses are introduced into the system.In his fragment 76,the philosopher Heraclitus wrote“The death of earth is to become water,and the death of water is to become air,and the death of air is to become fire,and reversely”1.This sentence describes well the“identity of the opposites”,one of the most fruitful principles of dialectic thinking from ancient Greece to Hegel and beyond.These thoughts came to my mind when I read a recent paper by Perego and coworkers2,in which they show how in nonlinear optical systems,spectrally asymmetric losses can generate gain in the very same beam that is affected by losses.The death of losses is to become gain.展开更多
文摘An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields and excellent regioselectivity. Functionalizations of the indole products were carried out affording highly valuable and versatile compounds. The indolization protocol was studied as a fundamental step for the preparation of pravadoline and 1-butyl-3-(1-naphthoyl)indole (JWH-073), bioactive molecules showing antinociceptic properties.
文摘Modulational instabilities in nonlinear optics are the fundamental processes that cause the transition from uniform states to structures in extended systems.Quite counterintuitively,such processes can be enhanced rather than inhibited when spectrally asymmetric losses are introduced into the system.In his fragment 76,the philosopher Heraclitus wrote“The death of earth is to become water,and the death of water is to become air,and the death of air is to become fire,and reversely”1.This sentence describes well the“identity of the opposites”,one of the most fruitful principles of dialectic thinking from ancient Greece to Hegel and beyond.These thoughts came to my mind when I read a recent paper by Perego and coworkers2,in which they show how in nonlinear optical systems,spectrally asymmetric losses can generate gain in the very same beam that is affected by losses.The death of losses is to become gain.
