Rat model for study of the essence of spleen deficiency and dampness in Chinese medicine

目的:通过构建脾虚水湿证型的动物模型探讨中医“脾虚”和“水湿”的本质。方法:以高脂低蛋白因素和游泳过度疲劳因素诱导脾虚水湿动物模型,选择临床常见的25项血清学指标进行检测,采用t检验、秩检验和回归分析对数据进行分析。结果:模型组大鼠的总蛋白、白蛋白、胃动素、干扰素-γ、白细胞介素-2、免疫球蛋白A、免疫球蛋白G、补体3水平均低于对照组(P=0.029,P=0.032,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001)。模型组的血清肌酐、总胆固醇、醛固酮、抗利尿激素、胃泌素、生长抑素、IL-4、心房钠尿肽和血管活性肠肽水平均高于对照组(P<0.001,P=0.015,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001,P<0.001)。两组在天冬氨酸转氨酶,丙氨酸转氨酶、球蛋白、白蛋白/球蛋白、血尿素氮、高密度脂蛋白,低密度脂蛋白水平无统计学差异。回归分析结果显示,模型组动物证候具有二维性,且此二维性在各生物学指标上难以明显分开。结论:脾虚常伴随水湿,细胞因子、免疫球蛋白、及胃肠激素是影响脾虚水湿的重要因素。

Diffuse infiltrative hemangioma of pancreas accompanied by Kasabach-Merritt Syndrome: A case report

To the Editor:Kasabach-Merritt syndrome(KMS)is a very rare life-threatening aggressive vascular tumor that is related to Kaposiform hemangioendothelioma and tufted angioma.It is characterized by thrombocytopenia and intravascular coagulation that occasionally develops into disseminated intravascular coagulation.[1,2]A rare incidence of diffuse infiltrative pancreatic hemangioma with a high possibility of missed diagnosis of KMS makes it a fatal disease.Here,we described a case diagnosed with diffuse infiltrative hemangioma(DIH)of pancreas accompanied by KMS and provided ultrasonic data for early and accurate diagnosis,and successful treatment experiences with sirolimus.