Aortic dissection is a disastrous disease;mortality is high in recent years especially.Most of patients die of aortic dissection rupture.In our country,morbidity of aortic dissection is increasing year by year,due
Esophageal rupture or perforation is a serious emergent disease.Without accurate diagnosis and effective treatment in time,it’s life-threatening.Esophageal rupture or perforation can be caused by:iatrogenic endoscopy...Esophageal rupture or perforation is a serious emergent disease.Without accurate diagnosis and effective treatment in time,it’s life-threatening.Esophageal rupture or perforation can be caused by:iatrogenic endoscopy examination and treatment,ligation and sclerotherapy of esophageal variceal,dilation of esophageal stricture,operative injury and so on; Spontaneous perforations; foreign body ingestion; trauma; tumor; calculus and ulcer of esophagus and so on.The key-point for the treatment of this disease lies in early diagnosis and accurate effective treatment.展开更多
Recent observational studies showed that breast-conserving surgery(BCS) resulted in superior survival compared to mastectomy in breast cancer patients. This study compared the clinical outcomes of BCS and mastectomy u...Recent observational studies showed that breast-conserving surgery(BCS) resulted in superior survival compared to mastectomy in breast cancer patients. This study compared the clinical outcomes of BCS and mastectomy using propensity score(PS)matching analysis, which had advantages over conventional methods in reducing bias. Nonmetastatic breast cancer patients who underwent BCS and mastectomy were matched 1:1 based on their PS. We used the Kaplan-Meier method and Cox-regression model to estimate the treatment effects. A total of 2,866 patients with a median follow-up time of 67 months were included in the original study population. Although the mastectomy cohort(N=1,219) had more advanced disease compared to the BCS cohort(N=1,647), LRFS was similar between the two groups(93.8% vs. 92.4%, P>0.05). BCS(vs. mastectomy) was associated with improved DFS(73.8% vs. 58.7%, P<0.01) and CSS(91% vs. 78.2%, P<0.01) in the original population. In the PS-matched population(N=1,668), clinicopathological features were equally distributed between the two cohorts. BCS(vs. mastectomy) was not associated with improved DFS(70.7% vs. 66.9%, P>0.05) or CSS(87.5% vs. 84.9%, P>0.05). We found that PS methods reduce bias when estimating treatment effects using observational data. BCS and mastectomy show equivalent outcomes in nonmetastatic breast cancer patients.展开更多
文摘Aortic dissection is a disastrous disease;mortality is high in recent years especially.Most of patients die of aortic dissection rupture.In our country,morbidity of aortic dissection is increasing year by year,due
文摘Esophageal rupture or perforation is a serious emergent disease.Without accurate diagnosis and effective treatment in time,it’s life-threatening.Esophageal rupture or perforation can be caused by:iatrogenic endoscopy examination and treatment,ligation and sclerotherapy of esophageal variceal,dilation of esophageal stricture,operative injury and so on; Spontaneous perforations; foreign body ingestion; trauma; tumor; calculus and ulcer of esophagus and so on.The key-point for the treatment of this disease lies in early diagnosis and accurate effective treatment.
基金supported by grants from the National Key Research and Development Program of China (2016YFC1302300)the National Natural Science Foundation of China (81720108029, 81621004, 81490750)+2 种基金Guangdong Science and Technology Department (2016B030229004)Guangzhou Science Technology and Innovation Commission (201803040015)supported by FountainValley Life Sciences Fund of University of Chinese Academy of Sciences Education Foundation
文摘Recent observational studies showed that breast-conserving surgery(BCS) resulted in superior survival compared to mastectomy in breast cancer patients. This study compared the clinical outcomes of BCS and mastectomy using propensity score(PS)matching analysis, which had advantages over conventional methods in reducing bias. Nonmetastatic breast cancer patients who underwent BCS and mastectomy were matched 1:1 based on their PS. We used the Kaplan-Meier method and Cox-regression model to estimate the treatment effects. A total of 2,866 patients with a median follow-up time of 67 months were included in the original study population. Although the mastectomy cohort(N=1,219) had more advanced disease compared to the BCS cohort(N=1,647), LRFS was similar between the two groups(93.8% vs. 92.4%, P>0.05). BCS(vs. mastectomy) was associated with improved DFS(73.8% vs. 58.7%, P<0.01) and CSS(91% vs. 78.2%, P<0.01) in the original population. In the PS-matched population(N=1,668), clinicopathological features were equally distributed between the two cohorts. BCS(vs. mastectomy) was not associated with improved DFS(70.7% vs. 66.9%, P>0.05) or CSS(87.5% vs. 84.9%, P>0.05). We found that PS methods reduce bias when estimating treatment effects using observational data. BCS and mastectomy show equivalent outcomes in nonmetastatic breast cancer patients.
