Objective To identify the constitutional and anatomical peculiarities of constitution of women of mature age.Methods There was completed comprehensive anthropometric and bio-electrical survey of 651mature women(relati...Objective To identify the constitutional and anatomical peculiarities of constitution of women of mature age.Methods There was completed comprehensive anthropometric and bio-electrical survey of 651mature women(relative norm)living in the Moscow region.Results The quantitative distribution of women by somatotypological affiliation was revealed;anthropometric and body component composition in representatives of different somatotypes were defined.Conclusion Thus,the performed study revealed and quantiely characterised the distribution of women according to their constitutional types in the studied population of mature age women living in Moscow region under the relative norm conditions.展开更多
Objective To study the influence of carcinogenic factors on tissues and organs of the maxillofacial region(MFR)by measuring the expression of biomarkers in the oral fluid.Methods We recruited 421 patients who were div...Objective To study the influence of carcinogenic factors on tissues and organs of the maxillofacial region(MFR)by measuring the expression of biomarkers in the oral fluid.Methods We recruited 421 patients who were divided into 2 groups:356 patients with a tumour of the MFR and 65 healthy people without somatic pathology in medical history.Results The effects of carcinogenic factors on the expression of biomarkers in the oral fluid in patients with a tumour of the MFR revealed a significant increase in the levels of biomarkers of tobacco use-MMP-8,TIMP-1,TIMP-2,and CA 72-4,CEA and CA 125;frequent use or abuse of alcohol-MMP-8,TIMP-1,TIMP-2,AFP and NSE;use of narcotics-TIMP-1 and TIMP-2;presence of occupational hazards in the medical history-MMP-8,MMP-9,TIMP-1 and TIMP-2;with a diagnostic sensitivity(DS)of over 60%.Also our analysis showed that the use of tobacco was significantly affecting the expression of TIMP-1and CA 125;frequent use or abuse of alcohol-CA 19-9,AFP and CEA;use of drugs had an impact on MMP-8expression.However,the occupational hazards in the medical history did not show a statistically significant effect.Conclusion Factors of carcinogenesis affect the expression of biomarkers in the oral fluid.The expression of the biomarkers of the MFR should be compared with that in the control group of patients with no carcinogenic factors.展开更多
Dear Editor,In morphogenesis,the sequential execution of tissue arrangement depends on a vast array of signaling proteins and cellular response.Several mechanisms of such response have been identified:apoptosis,prolif...Dear Editor,In morphogenesis,the sequential execution of tissue arrangement depends on a vast array of signaling proteins and cellular response.Several mechanisms of such response have been identified:apoptosis,proliferation,fusion,adhesion,sorting,transition,folding,migration and expansion.Different combinations of these responses lead to the formation of various anatomical structures[1,2].展开更多
文摘Objective To identify the constitutional and anatomical peculiarities of constitution of women of mature age.Methods There was completed comprehensive anthropometric and bio-electrical survey of 651mature women(relative norm)living in the Moscow region.Results The quantitative distribution of women by somatotypological affiliation was revealed;anthropometric and body component composition in representatives of different somatotypes were defined.Conclusion Thus,the performed study revealed and quantiely characterised the distribution of women according to their constitutional types in the studied population of mature age women living in Moscow region under the relative norm conditions.
文摘Objective To study the influence of carcinogenic factors on tissues and organs of the maxillofacial region(MFR)by measuring the expression of biomarkers in the oral fluid.Methods We recruited 421 patients who were divided into 2 groups:356 patients with a tumour of the MFR and 65 healthy people without somatic pathology in medical history.Results The effects of carcinogenic factors on the expression of biomarkers in the oral fluid in patients with a tumour of the MFR revealed a significant increase in the levels of biomarkers of tobacco use-MMP-8,TIMP-1,TIMP-2,and CA 72-4,CEA and CA 125;frequent use or abuse of alcohol-MMP-8,TIMP-1,TIMP-2,AFP and NSE;use of narcotics-TIMP-1 and TIMP-2;presence of occupational hazards in the medical history-MMP-8,MMP-9,TIMP-1 and TIMP-2;with a diagnostic sensitivity(DS)of over 60%.Also our analysis showed that the use of tobacco was significantly affecting the expression of TIMP-1and CA 125;frequent use or abuse of alcohol-CA 19-9,AFP and CEA;use of drugs had an impact on MMP-8expression.However,the occupational hazards in the medical history did not show a statistically significant effect.Conclusion Factors of carcinogenesis affect the expression of biomarkers in the oral fluid.The expression of the biomarkers of the MFR should be compared with that in the control group of patients with no carcinogenic factors.
文摘Dear Editor,In morphogenesis,the sequential execution of tissue arrangement depends on a vast array of signaling proteins and cellular response.Several mechanisms of such response have been identified:apoptosis,proliferation,fusion,adhesion,sorting,transition,folding,migration and expansion.Different combinations of these responses lead to the formation of various anatomical structures[1,2].
