Objective: The purpose of this study was to examine the relationship between cytokine genotypes and preeclampsia. Study design: We conducted a case-control study that examined cytokine genotypes among 150 primiparous ...Objective: The purpose of this study was to examine the relationship between cytokine genotypes and preeclampsia. Study design: We conducted a case-control study that examined cytokine genotypes among 150 primiparous preeclamptic women and 661 primiparous, normotensive women. Analyses were adjusted for age, prepregnancy cigarette smoking, and education. Results: Preeclamptic white women were more likely than normotensive white women to carry the up-regulating tumor necrosis factor-α -308 A/A (odds ratio, 4.1; 95% CI, 1.1-15.3) genotype. Both black and white women with preeclampsia were more likely than normotensive control subjects to carry the interleukin-1α -producing-4845 G/G genotype (black odds ratio, 11.6; 95% CI, 1.5-89.3; white odds ratio, 1.7; 95% CI, 0.7-3.9), -889 C/C genotype (black odds ratio, 5.1; 95% CI, 0.6-41.6; white odds ratio, 1.9; 95% CI, 0.8-4.7), and the interleukin-1α -4845/interleukin-1α -889/tinereukin-1β -3957 GCC/GCC haplotype (black odds ratio, 3.4; 95% CI, 1.3-8.7; white odds ratio, 2.1; 95% CI, 1.4-3.2). Conclusion: Cytokine genotypes were associated with preeclampsia and may identify women who are at high risk for preeclampsia.展开更多
Single-nucleotide polymorphisms （SNPs） of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus （T2DM）, but there are many conflicting results especially in Chinese populations. To invest...Single-nucleotide polymorphisms （SNPs） of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus （T2DM）, but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs ofADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects, rs 16861194 （-11426 A〉G） in the putative promoter of ADIPOQ was associated with T2DM （P = 0.007; OR = 1.29, 95% CI 1.08-1.55）. None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs 16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population.展开更多
Background The long-term effects of bone marrow-derived cells （BMC） transplantation in patients with acute myocardial infarction （AMI） have not been established. The present meta-analysis of randomized controlled ...Background The long-term effects of bone marrow-derived cells （BMC） transplantation in patients with acute myocardial infarction （AMI） have not been established. The present meta-analysis of randomized controlled trials with follow-up 〉2 years was performed to investigate the long-term effects of BMC therapy in patients after AMI. Methods Specific terms were used to conduct a systematic literature search of MEDLINE, EMBASE, the Cochrane Library and the Cochrane Central Register of Controlled Trials, and the China Biological Medicine Disk database from their inception to March 2012. A standardized protocol was used to extract information, and random effect model was used to analyze all data except major adverse events. Results Five trials comprising 510 patients were included. Compared with controls, BMC therapy significantly improved left ventricular ejection fraction （LVEF） （4.18%, 95% CI： 2.02% to 6.35%, P=-0.0002）, while mildly but not significantly reduced left ventricular end-systolic volume （-4.47 ml, 95% CI： -10.92 to 1.99, P=-0.17） and left ventricular end-diastolic volume （-2.29 ml, 95% CI： -9.96 to 5.39, P =0.56）. Subgroup analysis revealed that significant improvement of LVEF induced by BMC therapy could be observed in patients with baseline LVEF 〈42%, but disappeared in those with baseline LVEF 〉42%. There were trends in favor of BMC therapy for most major clinical adverse events, though most differences were not significant. Conclusions Intracoronary BMC infusion in patients with AMI seems to be safe and may further improve LVEF on top of standard therapy; especially the beneficial effects could last for long term. The findings need to be validated in the future.展开更多
文摘Objective: The purpose of this study was to examine the relationship between cytokine genotypes and preeclampsia. Study design: We conducted a case-control study that examined cytokine genotypes among 150 primiparous preeclamptic women and 661 primiparous, normotensive women. Analyses were adjusted for age, prepregnancy cigarette smoking, and education. Results: Preeclamptic white women were more likely than normotensive white women to carry the up-regulating tumor necrosis factor-α -308 A/A (odds ratio, 4.1; 95% CI, 1.1-15.3) genotype. Both black and white women with preeclampsia were more likely than normotensive control subjects to carry the interleukin-1α -producing-4845 G/G genotype (black odds ratio, 11.6; 95% CI, 1.5-89.3; white odds ratio, 1.7; 95% CI, 0.7-3.9), -889 C/C genotype (black odds ratio, 5.1; 95% CI, 0.6-41.6; white odds ratio, 1.9; 95% CI, 0.8-4.7), and the interleukin-1α -4845/interleukin-1α -889/tinereukin-1β -3957 GCC/GCC haplotype (black odds ratio, 3.4; 95% CI, 1.3-8.7; white odds ratio, 2.1; 95% CI, 1.4-3.2). Conclusion: Cytokine genotypes were associated with preeclampsia and may identify women who are at high risk for preeclampsia.
基金supported by the National Natural Science Foundation of ChinaNational Basic Research Pro-gram of China (973 Program)+5 种基金National High-tech R&D Program (863 Program)the Chinese Nutrition Soci-ety (No. 05015)the Dannon Institute, the Shanghai-Unilever Research and Development Fund (No. 06SU07007)the Shanghai Municipality Science & Tech-nology Commission (No. 05JC14090)the Shanghai Leading Academic Discipline Project (No. B205)the Knowledge Innovation Program of the Chinese Academy of Sciences (No. KSCX2-YW-R-01)
文摘Single-nucleotide polymorphisms （SNPs） of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus （T2DM）, but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs ofADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects, rs 16861194 （-11426 A〉G） in the putative promoter of ADIPOQ was associated with T2DM （P = 0.007; OR = 1.29, 95% CI 1.08-1.55）. None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs 16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population.
基金This study was supported by the grants from the National Natural Science Foundation of China （No. 81070083, 81070265） and Specialized Research Fund for the Doctoral Program of Higher Education （No. 20090092120059）. Conflict of interest： none declared.
文摘Background The long-term effects of bone marrow-derived cells （BMC） transplantation in patients with acute myocardial infarction （AMI） have not been established. The present meta-analysis of randomized controlled trials with follow-up 〉2 years was performed to investigate the long-term effects of BMC therapy in patients after AMI. Methods Specific terms were used to conduct a systematic literature search of MEDLINE, EMBASE, the Cochrane Library and the Cochrane Central Register of Controlled Trials, and the China Biological Medicine Disk database from their inception to March 2012. A standardized protocol was used to extract information, and random effect model was used to analyze all data except major adverse events. Results Five trials comprising 510 patients were included. Compared with controls, BMC therapy significantly improved left ventricular ejection fraction （LVEF） （4.18%, 95% CI： 2.02% to 6.35%, P=-0.0002）, while mildly but not significantly reduced left ventricular end-systolic volume （-4.47 ml, 95% CI： -10.92 to 1.99, P=-0.17） and left ventricular end-diastolic volume （-2.29 ml, 95% CI： -9.96 to 5.39, P =0.56）. Subgroup analysis revealed that significant improvement of LVEF induced by BMC therapy could be observed in patients with baseline LVEF 〈42%, but disappeared in those with baseline LVEF 〉42%. There were trends in favor of BMC therapy for most major clinical adverse events, though most differences were not significant. Conclusions Intracoronary BMC infusion in patients with AMI seems to be safe and may further improve LVEF on top of standard therapy; especially the beneficial effects could last for long term. The findings need to be validated in the future.
