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Effect of Ganduqing Granule on metabolic disorder and liver dysfunction in patients with chronic hepatitis B
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作者 You-Ping Liu Bo Li +3 位作者 Xiao-Dong Wang Shao-Ping Mi En-Ze Liu Mei Wei 《Traditional Medicine Research》 2017年第4期161-168,共8页
目的:探讨肝毒清胶囊改善慢性乙型肝炎患者肝功能异常的潜在机制.方法:采集30例乙型肝炎患者经肝毒清胶囊治疗前、后的血浆以及30例正常健康人的血浆,分别检测其肝功能,并使用超高效液相色谱-质谱联用法检测胆汁酸、脂质和肝脏氧化应激... 目的:探讨肝毒清胶囊改善慢性乙型肝炎患者肝功能异常的潜在机制.方法:采集30例乙型肝炎患者经肝毒清胶囊治疗前、后的血浆以及30例正常健康人的血浆,分别检测其肝功能,并使用超高效液相色谱-质谱联用法检测胆汁酸、脂质和肝脏氧化应激代谢产物的变化.结果:与正常对照组比较,慢性乙肝患者的肝功能明显异常,血浆中有8种代谢产物(3-硫酸甘氨鹅脱氧胆酸、甘氨鹅脱氧胆酸-3-葡萄糖醛酸,牛磺鹅脱氧胆酸,胆烷酸,二羟基雄甾烯酮硫酸,溶血磷脂酰胆碱(C18:3),溶血磷脂酰乙醇胺(C22:1);2,6-二氨基-4-羟基-5-N-甲基甲酰嘧啶)明显升高(P<0.05).经肝毒清胶囊治疗3周后,这8种升高的代谢产物均显著降低(P<0.05),并趋于正常水平.其中,3-硫酸甘氨鹅脱氧胆酸、甘氨鹅脱氧胆酸-3-葡萄糖醛酸,牛磺鹅脱氧胆酸和胆烷酸与胆汁酸代谢有关;二羟基雄甾烯酮硫酸,溶血磷脂酰胆碱(C18:3)和溶血磷脂酰乙醇胺(C22:1)与脂质代谢有关;2,6-二氨基-4-羟基-5-N-甲基甲酰嘧啶与肝脏的氧化应激相关.同时,血清中丙氨酸转氨酶,天冬氨酸转氨酶,总胆红素;直接胆红素和HBV病毒水平明显降低(均P<0.05).结论:肝毒清胶囊通过改善慢性乙肝患者的脂质代谢、胆汁酸代谢及氧化应激反应等,进而改善其肝功能. 展开更多
关键词 肝毒清胶囊 慢性乙肝 血浆 代谢产物
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Association between peroxisome proliferator-activated receptor γ gene polymorphism and susceptibility to northwest dryness syndrome 被引量:1
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作者 Wang Yan Wang Xiaozhong +4 位作者 Zeng Binfang Guo Feng He Yongquan He Jiaying Liu Bin 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2017年第2期201-206,共6页
OBJECTIVE:To investigate the relationship between gene polymorphism of peroxisome proliferator-activated receptor(PPAR) and susceptibility to northwest dryness syndrome(NDS).METHODS:The polymorphisms of 11 PPARl51, r... OBJECTIVE:To investigate the relationship between gene polymorphism of peroxisome proliferator-activated receptor(PPAR) and susceptibility to northwest dryness syndrome(NDS).METHODS:The polymorphisms of 11 PPARl51, rs13γ7 gene oci rs10510418, rs1263353640,rs17036188, rs2921190, rs4135247, rs4135275,rs4135283, rs6768587, rs709156, and rs7615916 were detected in 249 patients with NDS and 260 patients with non-NDS(control group) by using Snapshot single-nucleotide polymorphism typing technology.RESULTS:All locus detections were in accordance with Hardy-Weinberg equilibrium test.Compared with the control group, rs2921190 genotype frequency showed statistical difference in the NDS group(P < 0.05).Two-two comparison result showed that CC genotype frequency in the NDS group was higher than that in the control group.CT and TT genotype distribution frequencies showed differences between the two groups.The rare allele frequency in the NDS group was lower than that of the control group(P < 0.01).Multi-factor logistic regression analysis showed that the age and genotype entered the regression equation.The subjects in the age bracket 30-55 and 45-45 were1.796 and 1.561 times likely, respectively, than those in other age brackets to contract NDS,.The patients with CC genotype was only 0.524 times likely than those with CT/TT genotype to suffer from NDS.CONCLUSION:PPARsm was correlated γw gene rs2921190 polymorphiith the susceptibility to NDS. 展开更多
关键词 PPAR gamma 多型性 基因 遗传型 西北干症候群
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