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Inhibitors of protein kinase C 被引量:1
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作者 LIUShiying JIANGYuyang +2 位作者 CAOJiant LIUFeng ZHAOYufen 《Chinese Science Bulletin》 SCIE EI CAS 2005年第13期1293-1304,共12页
Protein kinase catalyzes the transfer of the γ-phosphoryl group from ATP to the hydroxyl groups of protein side chains, which plays critical roles in signal transduction pathways by transmitting extracellular signals... Protein kinase catalyzes the transfer of the γ-phosphoryl group from ATP to the hydroxyl groups of protein side chains, which plays critical roles in signal transduction pathways by transmitting extracellular signals across the plasma membrane and nuclear membrane to the destination sites in the cytoplasm and the nucleus. Protein kinase C (PKC) is a superfamily of phospholipid-dependent Ser/Thr kinase. There are at least 12 isozymes in PKC family. They are distributed in different tissues and play different roles in physiological processes. On account of their concern with a variety of pathophysiologic states, such as cancer, inflammatory conditions, autoimmune disorder, and cardiac diseases, the inhibitors, which can inhibit the activity of PKC and the interaction of cytokine with receptor, and interfere signal transduction pathway, may be candidates of therapeu-tic drugs. Therefore, intense efforts have been made to de-velop specific protein kinase inhibitors as biological tools and therapeutic agents. This article reviews the recent develop-ment of some of PKC inhibitors based on their interaction with different conserved domains and different inhibition mechanisms. 展开更多
关键词 蛋白质激活酶C 抑制剂 信号转换 免疫能力
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