Endocytic tracers and marker enzyme of lysosomeswere used in the present study to analyze the processesof autophagocytosis and endocytosis, and the convergentpoint of these two pathways in Leydig cells. The endocytica...Endocytic tracers and marker enzyme of lysosomeswere used in the present study to analyze the processesof autophagocytosis and endocytosis, and the convergentpoint of these two pathways in Leydig cells. The endocyticand autophagic compartments call be easily identified inLeydig cells, which makes easier to define the stages of twopathways than was possible before. The evidences indicated that the late endosomes (dense MVBs) deliver theirendocytosed gold tracers together with lysosomal enzymesto the early autophagosomes and they are the convergentpoint of the two pathways. During this convergent process,the early autophagosomes transform into late autophagosomes and the late endosomes transform into mature lysosomes.展开更多
文摘Endocytic tracers and marker enzyme of lysosomeswere used in the present study to analyze the processesof autophagocytosis and endocytosis, and the convergentpoint of these two pathways in Leydig cells. The endocyticand autophagic compartments call be easily identified inLeydig cells, which makes easier to define the stages of twopathways than was possible before. The evidences indicated that the late endosomes (dense MVBs) deliver theirendocytosed gold tracers together with lysosomal enzymesto the early autophagosomes and they are the convergentpoint of the two pathways. During this convergent process,the early autophagosomes transform into late autophagosomes and the late endosomes transform into mature lysosomes.
