To evaluate the efficacy of dynamic multi-slice spiral computed tomography (MSCT) for providing quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs) and differentiating solitary pulm...To evaluate the efficacy of dynamic multi-slice spiral computed tomography (MSCT) for providing quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs) and differentiating solitary pulmonary nodules (SPNs). Methods: 37 patients with SPNs (diameter<4cm; 24 with maliagnant; 6 with benign; 7 with inflammatory) underwent multi-location dynamic contrast material-enhanced (90 mL, 4 mL/s) serial CT. Peak height and ratio of peak height of the SPN to that of the aorta were measured. Frecontrast attenuation was recorded. Perfusion was calculated from the maxi mum gradient of the time-attenuation curve and the peak height of the aorta. Results: Peak heights of malignant (37.98 HU+17.97) and inflammatory (43.86 HU+14.20) SPNs were significantly higher than those of benign SPNs (5.65 HU+6.43) (P<0.001; P<0.001). No statistically significant difference in the peak height was found between malignant and inflammatory SPNs (P=0.647>0.01). SFN-to-aorta ratio in inflammatory SPNs (20.78%±4.14) was significantly higher than that in benign (2.00%±2.26) and malig nant (14.63%±6.22) SPNs (P<0.001; P=0.021<0.05). SPN-to-aorta ratio in malignant SPNs was signifi cantly higher than that in benign SPNs (P<0.001). Perfusion value in inflammatory SPNs [78.39 mL/(min100g)±55.18] was significantly higher than that of benign [2.13 mL/(min.100g)±2.84] and malignant [33.91mL/(min.100g)±15.58] SPNs (P <0.001; P=0.001<0.01). Perfusion value in malignant SPNs was significantly higher than that in benign SPNs (P<0.001). Precontrast attenuations of inflammatory (39.36 HU±9.57)and benign (37.73 HU±8.39) SPNs were lower than that of malignant SPNs (45.73 HU±4.21) (P=0.04<0.05; P=0.014<0.05). No statistically significant difference in the precontrast attenuation was found between benign and inflammatory SPNs (P=0.836>0.01). Conclusion: MSCT provides quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs) and is applicable diagnostic method for differentiating SPNs.展开更多
Objective To investigate the methods of dynamic enhanced multi-slice spiral CT in evaluation of blood flow patterns of solitary pulmonary nodules (SPNs) with enhancement. Methods Seventy-eight patients with SPNs (≤4 ...Objective To investigate the methods of dynamic enhanced multi-slice spiral CT in evaluation of blood flow patterns of solitary pulmonary nodules (SPNs) with enhancement. Methods Seventy-eight patients with SPNs (≤4 cm) with strong enhancement underwent dynamic multi-slice spiral CT (Marconi Mx8000) scan before and after contrast enhancement by injecting contrast material with a rate of 4 mL/s. For the 40 patients in protocol one, one scan was obtained every 2 seconds during 15--45 and 75--105 seconds after injection, while for the 38 patients in protocol two, one scan was obtained every 2 seconds during 11--41 and 71--101 seconds. For all the patients, one scan was obtained every 30 seconds during 2--9 minutes. The section thickness was 2.5 mm for lesions ≤3 cm and 5 mm for lesions >3 cm. Standard algorithm was used in the image reconstruction. Precontrast and postcontrast attenuation on every scan was recorded. The perfusion, peak height, ratio of peak height of the SPN to that of the aorta and mean transit time were calculated. Results The peak height, perfusion, ratio of peak height of the SPN to that of the aorta and mean transit time in malignant SPNs were 34.85 Hu±10.87 Hu, 30.37 ml/(min·100 g)±11.14 ml/(min·100 g), 13.78%± 3.96% , 14.19 s±6.19 s respectively in protocol one, while those in protocol two were 36.62 Hu±10.75 Hu, 30.01 ml/(min·100 g)±8.10 ml/(min·100 g), 14.70 %±4.71%, 13.91 s±4.82 s respectively. No statistically significant differences were found between the peak height (t= 0.673, P=0.503), perfusion (t= 0.152 , P=0.880), ratio of peak height of the SPN to that of the aorta (t= 0.861, P=0.393) and mean transit time (t= 0.199, P=0.843) in malignant SPNs measured in protocol one and those measured in protocol two. All mean transit time in protocol two (36/36) were obtained, but only part of them (25/32) were obtained in protocol one. Conclusion Dynamic enhanced multi-slice spiral CT is a non-invasive method for quantitative evaluation of blood flow patterns of SPNs with enhancement and scans beginning at 11 seconds after injection of contrast material is suggested.展开更多
文摘To evaluate the efficacy of dynamic multi-slice spiral computed tomography (MSCT) for providing quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs) and differentiating solitary pulmonary nodules (SPNs). Methods: 37 patients with SPNs (diameter<4cm; 24 with maliagnant; 6 with benign; 7 with inflammatory) underwent multi-location dynamic contrast material-enhanced (90 mL, 4 mL/s) serial CT. Peak height and ratio of peak height of the SPN to that of the aorta were measured. Frecontrast attenuation was recorded. Perfusion was calculated from the maxi mum gradient of the time-attenuation curve and the peak height of the aorta. Results: Peak heights of malignant (37.98 HU+17.97) and inflammatory (43.86 HU+14.20) SPNs were significantly higher than those of benign SPNs (5.65 HU+6.43) (P<0.001; P<0.001). No statistically significant difference in the peak height was found between malignant and inflammatory SPNs (P=0.647>0.01). SFN-to-aorta ratio in inflammatory SPNs (20.78%±4.14) was significantly higher than that in benign (2.00%±2.26) and malig nant (14.63%±6.22) SPNs (P<0.001; P=0.021<0.05). SPN-to-aorta ratio in malignant SPNs was signifi cantly higher than that in benign SPNs (P<0.001). Perfusion value in inflammatory SPNs [78.39 mL/(min100g)±55.18] was significantly higher than that of benign [2.13 mL/(min.100g)±2.84] and malignant [33.91mL/(min.100g)±15.58] SPNs (P <0.001; P=0.001<0.01). Perfusion value in malignant SPNs was significantly higher than that in benign SPNs (P<0.001). Precontrast attenuations of inflammatory (39.36 HU±9.57)and benign (37.73 HU±8.39) SPNs were lower than that of malignant SPNs (45.73 HU±4.21) (P=0.04<0.05; P=0.014<0.05). No statistically significant difference in the precontrast attenuation was found between benign and inflammatory SPNs (P=0.836>0.01). Conclusion: MSCT provides quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs) and is applicable diagnostic method for differentiating SPNs.
文摘Objective To investigate the methods of dynamic enhanced multi-slice spiral CT in evaluation of blood flow patterns of solitary pulmonary nodules (SPNs) with enhancement. Methods Seventy-eight patients with SPNs (≤4 cm) with strong enhancement underwent dynamic multi-slice spiral CT (Marconi Mx8000) scan before and after contrast enhancement by injecting contrast material with a rate of 4 mL/s. For the 40 patients in protocol one, one scan was obtained every 2 seconds during 15--45 and 75--105 seconds after injection, while for the 38 patients in protocol two, one scan was obtained every 2 seconds during 11--41 and 71--101 seconds. For all the patients, one scan was obtained every 30 seconds during 2--9 minutes. The section thickness was 2.5 mm for lesions ≤3 cm and 5 mm for lesions >3 cm. Standard algorithm was used in the image reconstruction. Precontrast and postcontrast attenuation on every scan was recorded. The perfusion, peak height, ratio of peak height of the SPN to that of the aorta and mean transit time were calculated. Results The peak height, perfusion, ratio of peak height of the SPN to that of the aorta and mean transit time in malignant SPNs were 34.85 Hu±10.87 Hu, 30.37 ml/(min·100 g)±11.14 ml/(min·100 g), 13.78%± 3.96% , 14.19 s±6.19 s respectively in protocol one, while those in protocol two were 36.62 Hu±10.75 Hu, 30.01 ml/(min·100 g)±8.10 ml/(min·100 g), 14.70 %±4.71%, 13.91 s±4.82 s respectively. No statistically significant differences were found between the peak height (t= 0.673, P=0.503), perfusion (t= 0.152 , P=0.880), ratio of peak height of the SPN to that of the aorta (t= 0.861, P=0.393) and mean transit time (t= 0.199, P=0.843) in malignant SPNs measured in protocol one and those measured in protocol two. All mean transit time in protocol two (36/36) were obtained, but only part of them (25/32) were obtained in protocol one. Conclusion Dynamic enhanced multi-slice spiral CT is a non-invasive method for quantitative evaluation of blood flow patterns of SPNs with enhancement and scans beginning at 11 seconds after injection of contrast material is suggested.
