Traumatic brain injury（TBI）and spinal cord injury（SCI）are leading causes of death and disability worldwide（Center for Disease Control,2006）.Both injuries are induced by external traumatic event and likely happen...Traumatic brain injury（TBI）and spinal cord injury（SCI）are leading causes of death and disability worldwide（Center for Disease Control,2006）.Both injuries are induced by external traumatic event and likely happen together.After the primary traumatic incident,the secondary injury,including ischemic,inflammatory,metabolic and biochemical cascades,is likely more devastating（Blumbergs,1997）.To date,all clinical trials have failed to cure TBI and SCI,due to the展开更多
Previous neuropathological studies regarding traumatic brain injury have primarily focused on changes in large structures, for example, the clinical prognosis after cerebral contusion, intrace- rebral hematoma, and ep...Previous neuropathological studies regarding traumatic brain injury have primarily focused on changes in large structures, for example, the clinical prognosis after cerebral contusion, intrace- rebral hematoma, and epidural and subdural hematoma. In fact, many smaller injuries can also lead to severe neurological disorders. For example, cerebral microbleeds result in the dysfunc- tion of adjacent neurons and the disassociation between cortex and subcortical structures. These tiny changes cannot be adequately visualized on CT or conventional MRI. In contrast, gradient echo sequence-based susceptibility-weighted imaging is very sensitive to blood metabolites and microbleeds, and can be used to evaluate traumatic cerebral microbleeds with high sensitivity and accuracy. Cerebral microbleed can be considered as an important imaging marker for dif- fuse axonal injury with potential relevance for prognosis. For this reason, based on experimental and clinical studies, this study reviews the role of imaging data showing traumatic cerebral microbleeds in the evaluation of cerebral neuronal injury and neurofunctional loss.展开更多
文摘Traumatic brain injury（TBI）and spinal cord injury（SCI）are leading causes of death and disability worldwide（Center for Disease Control,2006）.Both injuries are induced by external traumatic event and likely happen together.After the primary traumatic incident,the secondary injury,including ischemic,inflammatory,metabolic and biochemical cascades,is likely more devastating（Blumbergs,1997）.To date,all clinical trials have failed to cure TBI and SCI,due to the
基金supported by grants from the State-Funded Construction Projects Key Clinical Specialist(2013-2015)the Hunan Provincial Science and Technology Department,No.2009FJ3092
文摘Previous neuropathological studies regarding traumatic brain injury have primarily focused on changes in large structures, for example, the clinical prognosis after cerebral contusion, intrace- rebral hematoma, and epidural and subdural hematoma. In fact, many smaller injuries can also lead to severe neurological disorders. For example, cerebral microbleeds result in the dysfunc- tion of adjacent neurons and the disassociation between cortex and subcortical structures. These tiny changes cannot be adequately visualized on CT or conventional MRI. In contrast, gradient echo sequence-based susceptibility-weighted imaging is very sensitive to blood metabolites and microbleeds, and can be used to evaluate traumatic cerebral microbleeds with high sensitivity and accuracy. Cerebral microbleed can be considered as an important imaging marker for dif- fuse axonal injury with potential relevance for prognosis. For this reason, based on experimental and clinical studies, this study reviews the role of imaging data showing traumatic cerebral microbleeds in the evaluation of cerebral neuronal injury and neurofunctional loss.
