Molecular hydrogen(H_(2))is a physiologically inert gas.However,during the last 10 years,increasing evidence has revealed its biological functions under pathological conditions.More specifically,H_(2) has protective e...Molecular hydrogen(H_(2))is a physiologically inert gas.However,during the last 10 years,increasing evidence has revealed its biological functions under pathological conditions.More specifically,H_(2) has protective effects against a variety of diseases,particularly nervous system disorders,which include ischemia/reperfusion injury,traumatic injury,subarachnoid hemorrhage,neuropathic pain,neurodegenerative diseases,cognitive dysfunction induced by surgery and anesthesia,anxiety,and depression.In addition,H_(2) plays protective roles mainly through anti-oxidation,anti-inflammation,antiapoptosis,the regulation of autophagy,and preservation of mitochondrial function and the blood-brain barrier.Further,H_(2) is easy to use and has neuroprotective effects with no major side-effects,indicating that H_(2) administration is a potential therapeutic strategy in clinical settings.Here we summarize the H_(2) donors and their pharmacokinetics.Meanwhile,we review the effectiveness and safety of H_(2) in the treatment of various nervous system diseasesbased on preclinical and clinical studies,leading to the conclusion that H_(2) can be a simple and effective clinical therapy for CNS diseases such as ischemia-reperfusion brain injury,Parkinson's disease,and diseases characterized by cognitive dysfunction.The potential mechanisms involved in the neuroprotective effect of H_(2) are also analyzed.展开更多
基金supported by the National Natural Science Foundation of China(81770855 and 81773717)the Taishan Scholarship from the Shandong Province Government(ts201511057)the High-Level Talent Training Program of Taishan Medical University(2018GCC08)。
文摘Molecular hydrogen(H_(2))is a physiologically inert gas.However,during the last 10 years,increasing evidence has revealed its biological functions under pathological conditions.More specifically,H_(2) has protective effects against a variety of diseases,particularly nervous system disorders,which include ischemia/reperfusion injury,traumatic injury,subarachnoid hemorrhage,neuropathic pain,neurodegenerative diseases,cognitive dysfunction induced by surgery and anesthesia,anxiety,and depression.In addition,H_(2) plays protective roles mainly through anti-oxidation,anti-inflammation,antiapoptosis,the regulation of autophagy,and preservation of mitochondrial function and the blood-brain barrier.Further,H_(2) is easy to use and has neuroprotective effects with no major side-effects,indicating that H_(2) administration is a potential therapeutic strategy in clinical settings.Here we summarize the H_(2) donors and their pharmacokinetics.Meanwhile,we review the effectiveness and safety of H_(2) in the treatment of various nervous system diseasesbased on preclinical and clinical studies,leading to the conclusion that H_(2) can be a simple and effective clinical therapy for CNS diseases such as ischemia-reperfusion brain injury,Parkinson's disease,and diseases characterized by cognitive dysfunction.The potential mechanisms involved in the neuroprotective effect of H_(2) are also analyzed.
