The implication of neurovascular unit signaling in controlling the subtle balance between injury and repair following ischemic stroke

Neurovascular unit（NVU）：Brain microvasculature has a close structural and functional relationship with brain parenchyma,an aspect governed by the NVU（Hermann and El Ali,2012）.The concept of it was introduced by the Stroke Progress Review Group who defined it as triad of neurons.

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical cord.MSCs have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue repair.MSCs enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC secretome.An increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

Chronotype and self-reported sleep,alertness,and mental health in U.S. sailors

Service members are at risk for sleep and psychological conditions affecting their readiness. Chronotype(“morningness”or “eveningness”) is strongly associated with sleep, health and performance. The objective of this study was to examine associations between validated measures of chronotype and sleep quality, daytime functioning, alertness,and symptoms of depression, anxiety, and post-traumatic stress disorder(PTSD) in US service members(n=298).Although predominantly young males(who skew toward eveningness in civilian populations), these Sailors skewed toward morningness(35.6% morning, 51.3% intermediate). Eveningness was associated with symptoms of depression and PTSD(P<0.01), less time in bed(P<0.05), more sleep disruption(P<0.01), and poorer daytime functioning and alertness(P<0.05). Evening types were less likely to consider sleep important for performance(P<0.05). To maximize service member readiness, schedules should be aligned with endogenous rhythms, whenever possible, and evening chronotypes may benefit from targeted interventions. Chronotype should be examined alongside health and readiness in service members.

Simultaneous dual-contrast three-dimensional imaging in live cells via optical diffraction tomography and fluorescence

We report a dual-contrast method of simultaneously measuring and visualizing the volumetric structural information in live biological samples in three-dimensional(3D) space. By introducing a direct way of deriving the 3D scattering potential of the object from the synthesized angular spectra, we obtain the quantitative subcellular morphology in refractive indices(RIs) side-by-side with its fluorescence signals. The additional contrast in RI complements the fluorescent signal, providing additional information of the targeted zones. The simultaneous dual-contrast 3D mechanism unveiled interesting information inaccessible with previous methods, as we demonstrated in the human immune cell(T cell) experiment. Further validation has been demonstrated using a Monte Carlo model.

Gender differences associated with orienting attentional networks in healthy subjects

Background Selective attention is considered one of the main components of cognitive functioning.A number of studies have demonstrated gender differences in cognition.This study aimed to investigate the gender differences in selective attention in healthy subjects.Methods The present experiment examined the gender differences associated with the efficiency of three attentional networks：alerting,orienting,and executive control attention in 73 healthy subjects （38 males）.All participants performed a modified version of the Attention Network Test （ANT）.Results Females had higher orienting scores than males （t=2.172,P 〈0.05）.Specifically,females were faster at covert orienting of attention to a spatially cued location.There were no gender differences between males and females in alerting （t=0.813,P 〉0.05） and executive control （t=0.945,P 〉0.05） attention networks.Conclusions There was a significant gender difference between males and females associated with the orienting network.Enhanced orienting attention in females may function to motivate females to direct their attention to a spatially cued location.