Activation-induced cell death(AICD),which results from the interaction between Fas and Fas ligand,is responsible for maintaining tolerance to self-antigen.A defect in AICD may lead to development of autoimmunity.Durin...Activation-induced cell death(AICD),which results from the interaction between Fas and Fas ligand,is responsible for maintaining tolerance to self-antigen.A defect in AICD may lead to development of autoimmunity.During the last several years,much progress has been made in understanding the mechanism(s) of AICD and its potential role in the pathogenesis of autoimmune diseases.In this review,we summarize the most recent progress on the regulation of the susceptibility of T cells to AICD and its possible involvement in autoimmune diseases.Cellular & Molecular Immunology.2004;1(3):186-192.展开更多
基金supported by grants from the National Institutes of Health(NIH)(R03 AR047412,P01 AR045652 and R01 AR049775)Arthritis National Research Foundation+2 种基金American Heart Association(AHA0355509Z)to JZa grant from National Natural Science Foundation of China(30340059)to YLJZ is supported by an independent scientist award from the NIH(K02 AR049047).
文摘Activation-induced cell death(AICD),which results from the interaction between Fas and Fas ligand,is responsible for maintaining tolerance to self-antigen.A defect in AICD may lead to development of autoimmunity.During the last several years,much progress has been made in understanding the mechanism(s) of AICD and its potential role in the pathogenesis of autoimmune diseases.In this review,we summarize the most recent progress on the regulation of the susceptibility of T cells to AICD and its possible involvement in autoimmune diseases.Cellular & Molecular Immunology.2004;1(3):186-192.
