Clinical features of obsessive-compulsive disorder and its impact on pharmacotherapeutic effect

Objective To explore the relation of clinical characteristics and drug therapeutic effect in patients with obsessive-compulsive disorder(OCD).Methods Totally 87 patients meeting the DSM-Ⅳ criteria for OCD were recruited.They were assessed with the Y-BOCS and Obsessive-Compulsive Inventory-Revised(OCI-R)to evaluate the degree of obsessive-compulsive symptoms and distress,and Beck Depression Inventor-Ⅱ and Beck Anxiety Inventory to evaluate the degree of depression and anxiety,Childhood Trauma Questionnaire was used to measure the childhood trauma,and the patients were arranged to complete the follow-up of 16 weeks,the reductive rate of Y-BOCS was used to assess efficacy.Pearson correlation and binary logistic stepwise regression were used to analyze the relationship between clinical characteristics and therapeutic effect.Results The total effective rate of treatment was 65.3%(47/27).Compared with early-onset OCD patients(n=40),late-onset OCD patients(n=47)showed higher checking scores of OCI-R(3.7±3.3 vs 6.3±3.7;t=-2.50,P<0.05).Higher-trau-ma OCD patients(n=52)scored higher than lower-trauma OCD patients(n=23)in obsession and Beck Depression Inventor-Ⅱ scores(6.8±3.3 vs.4.5±3.5,t=-2.14,P=0.038;23.8±12.1 vs.15.6±5.8,t=-3.08,P=0.003).The age at onset of OCD was positively correlated with the reductive rate of Y-BOCS(r=0.25,P<0.05).Logistic regression analysis reported that age of onset entered the regression model(OR=1.15,P<0.05).Conclusion It suggests that OCD patients with more childhood trauma experience may exhibit more severe obsession,and those with earlier age of onset may exhibit the worse therapeutic effect.

The randomized controlled study of the effect of medication with cognitive behavioral therapy and medication on obsessive-compulsive disorder

Objective To compare the effect between the group of 5-selective serotonin reuptake inhibitor(SSRIs)treatment and the group of SSRIs combining cognitive behavioral therapy(CBT).Methods Eighty patients meeting the Diagnostic and Statistical Manual of Mental Disorders,Fourth edition criteria for obsessive-compulsive dis-

Effect of group cognitive behavioral therapy on cognitive function of patients with obsessive-compulsive disorder

Objective To explore the effect of group cognitive behavior therapy (GCBT) on symptom relief and cognitive function improvement of patients with obsessive-compulsive disorder (OCD). Methods Forty-eight OCD patients who met the DSM-Ⅳ-TR diagnostic criteria were introduced into this study.