Objective To explore the pattern of inter-hemispheric resting-state mirror functional homotopy in the drugnaive obsessive-compulsive disorder(OCD).Methods Twenty patients with OCD meeting the DSM-Ⅳ-TR criteria and 20...Objective To explore the pattern of inter-hemispheric resting-state mirror functional homotopy in the drugnaive obsessive-compulsive disorder(OCD).Methods Twenty patients with OCD meeting the DSM-Ⅳ-TR criteria and 20 gender-,age-,education-matched healthy subjects participated in the resting-state brain functional magnetic resonance imaging scan.The Y-BOCS,HAMD1 7 and HAMA were used to assess the clinical symptoms(i.e.obsessive,compulsive,depressive and anxiety symptoms).Based on the data processing & analysis for(resting-state)brain imaging(DPABI)software,a voxel-mirrored homotopic connectivity(VMHC)approach was used to explore the pattern of inter-hemispheric resting-state mirror functional homotopy in OCD;partial correlation analysis was used to analyze the relationship between the whole brain VMHC value and clinical symptoms in OCD.Results Compared with the controls,the OCD patients showed decreased VMHC values in the orbitofrontal cortex(0.76±0.23 vs.0.39±0.13,t=-5.46,P<0.01,gaussian random field corrected,two-tailed);the VMHC value of bilateral dorsolateral prefrontal cortex was negatively correlated with obsessive thought(r=-0.912,P<0.01,Bonferroni correction).Conclusion Reduced interhemispheric resting-state functional homotopy in the orbitofrontal cortex is observed in OCD patients,and the interhemispheric resting-state functional homotopy in the bilateral dorsolateral prefrontal cortex may be related with obsessive thought of OCD patients.展开更多
文摘Objective To explore the pattern of inter-hemispheric resting-state mirror functional homotopy in the drugnaive obsessive-compulsive disorder(OCD).Methods Twenty patients with OCD meeting the DSM-Ⅳ-TR criteria and 20 gender-,age-,education-matched healthy subjects participated in the resting-state brain functional magnetic resonance imaging scan.The Y-BOCS,HAMD1 7 and HAMA were used to assess the clinical symptoms(i.e.obsessive,compulsive,depressive and anxiety symptoms).Based on the data processing & analysis for(resting-state)brain imaging(DPABI)software,a voxel-mirrored homotopic connectivity(VMHC)approach was used to explore the pattern of inter-hemispheric resting-state mirror functional homotopy in OCD;partial correlation analysis was used to analyze the relationship between the whole brain VMHC value and clinical symptoms in OCD.Results Compared with the controls,the OCD patients showed decreased VMHC values in the orbitofrontal cortex(0.76±0.23 vs.0.39±0.13,t=-5.46,P<0.01,gaussian random field corrected,two-tailed);the VMHC value of bilateral dorsolateral prefrontal cortex was negatively correlated with obsessive thought(r=-0.912,P<0.01,Bonferroni correction).Conclusion Reduced interhemispheric resting-state functional homotopy in the orbitofrontal cortex is observed in OCD patients,and the interhemispheric resting-state functional homotopy in the bilateral dorsolateral prefrontal cortex may be related with obsessive thought of OCD patients.
