Low level of serum sex hormone binding globulin is associated with the occurrence of metabolic syndrome

Objective To investigate the relationship between serum sex hormone binding globulin (SHBG) and metabolic syndrome (MS) in Chinese young population.Methods A total of 797 patients were enrolled and subdivided into MS group (n=377) and non-MS group (n=420) .Body height and weight were measured for

A prospective study on the influence of metabolic syndrome on the risks of cardiovascular disease events and all-cause mortality for urban residents aged 40-79 years in Guiyang

Objective To explore the influence of metabolic syndrome on the risks of cardiovascular disease(CVD)events and all-cause mortality.Methods In this prospective cohort study,urban residents aged 40-79 years in Guiyang were followed-up for three years.The end-points were CVD events and all-cause mortality.COX proportional hazards model were used for the corresponding hazard ratios(HRs)of CVD events and all-cause mortality.Metabolic syndrome was defined according to the 2005 International Diabetes Federation(IDF)criteria.Results A total of 7313 subjects were included.146 cases of CVD events and 80 cases of all-cause mortality were recorded.

Metabolic outcomes of type 2 diabetes patients with different diabetic durations under the standardized metabolic disease management model

Objective To explore the metabolic outcomes of type 2 diabetes patients with different durations after 1 year treatment under the standardized metabolic disease management model.Methods(1)From September 2017 to September 2018,345 type 2 diabetes patients in the Standardized Metabolic Management Center(MMC)of Shanghai General Hospital were recruited and included in this research.

Clinical and metabolic characteristics in 165 patients with common COVID-19

Objective To retrospectively analyze the clinical and serological characteristics in rehabilitated patients with common novel coronavirus pneumonia(COVID-19).Methods A total of 165 patients with common COVID-19were enrolled in this retrospective study,in which clinical data was collected from February 23 to March 15,2020 in Leishenshan Hospital(Wuhan,China).

A cohort study of ten-year cardiovascular disease risk among subtypes of pre-diabetes population aged 40 and above in Guiyang urban area

Objective To investigate the 10-year risk for cardiovascular diseases (CVD) among different subtypes of pre-diabetes (Pre-DM) residents aged 40 and above in Guiyang urban area and to analyze the influencing factors.

Correlation of serum and follicular fluid SREBP1c and LRG1 levels with insulin resistance in PCOS patients

Objective To investigate the serum and follicular fluid levels of sterol regulatory element-binding protein 1 c(SREBP-lc),leucine-rich α-2-glycoprotein 1 (LRG1)and the correlation with insulin resistance (IR) in nonovarian etiology infertility patients and polycystic ovary syndrome (PCOS) patients with or without IR.

Serum TSH levels in women aged 40 and above:association with lifespan and 10-year mortality

Objective To investigate the relationship between thyroid-stimulating hormone(TSH)levels and 10-year mortality in women aged 40 years and older.Methods Residents aged 40 and over in urban areas of Guiyang City who participated in the“Epidemiological Study of Cancer Risk in Patients with Type 2 Diabetes in China(REACTION)”were followed up in 2011.Finally,5614 people were enrolled,and the baseline general information,physical examination and TSH detection were carried out.The average follow-up was(9.77±1.55)years,and the treatment and death of thyroidrelated diseases were recorded.The Cox proportional hazards model was used to analyze the relationship between TSH level and 10-year mortality in middle-aged and elderly women,and plotting survival time curves(Kaplan-Meier curves)to study the association between elevated TSH levels and lifespan in subjects under 65 years old.Results The multivariate Cox proportional hazards model showed that compared with the normal group,after multivariate adjustment,the risk of death in the TSH increased group was decreased(HR=0.644,95%CI0.478-0.868,P<0.05).

Risk factors of abnormal urinary albumin/ creatinine ratio in people with obesity

Objective To explore the clinical characteristics and risk factors of abnormal urinary albumin/creatinine ratio(UACR)in obese population.Methods Baseline data from 2011 to 2012 in Henan Sub-center of"Risk Evaluation of Cancers in Chinese Diabetic Individuals:A longitudinal(REACTION)study"were utilized and those of body mass index≥28 kg/m^(2) were screened.The patients were divided into UACR normal group and UACR abnormal group(101 pairs)upon being matched on a 1:1 basis by age and gender.Multivariate logistic regression analysis,receiver operating characteristic(ROC)curve,and restricted cubic spline(RCS)analysis were performed to explore the risk factors for abnormal UACR.Results Compared with the normal UACR group,the UACR abnormal group had a higher number of alcohol consumers,a higher prevalence of hypertension,elevated systolic blood pressure,and triglyceride(all P<0.05).Multivariate logistic regression analysis showed that alcohol consumption(P=0.008).

Correlation of urinary uric acid excretion with obesity and abdominal obesity in newly diagnosed patients with type 2 diabetes mellitus

Objective To investigate the association of uric acid excretion (UUAE) with obesity and abdominal obesity in newly diagnosed patients with type 2 diabetes mellitus(T2DM).Methods A total of 1 175 newly diagnosed T2DM patients hospitalized in the Department of Endocrinology and Metabolism of Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine were enrolled in this study from January 2006to December 2012.According to the quartile of UUAE.

Association between remnant cholesterol levels and incident diabetic retinopathy in middle-aged and older patients with diabetes

Objective To investigate the association between remnant cholesterol (RC) and the risk of diabetic retinopathy (DR) in middle-aged and older individuals with diabetes.Methods Based on the Shanghai Nicheng Cohort Study database,the data of 1 255 individuals with diabetes aged 55-70 years at baseline (2013-2014)with complete fundus photographs and serum cholesterol data in Nicheng,Shanghai,were analyzed.

Clinical characteristics of elderly-onset gouty arthritis and risk factors for tophi

Objective To analyze the clinical characteristics of elderly-onset gouty arthritis and risk factors of tophi.Methods A total of 1 239 gout patients were retrospectively selected in the outpatient department of the Gout Clinical Medical Center of the Affiliated Hospital of Qingdao University from 2016 to 2022.According to age of onset.

Replication of association study between type 2 diabetes mellitus and IGF2BP2 in Han Chinese population

Background The association between IGF2BP2 and type 2 diabetes mellitus （T2DM） has been repeatedly confirmed among different ethnic populations. However, in several genome-wide association studies （GWAS） from the Chinese Han population, the gene IGF2BP2 has not been replicated. The results of relevant studies for the association between IGF2BP2 and T2DM showed controversy in Chinese Han population. It is necessary to systematically evaluate the contribution of common variants in IGF2BP2 to T2DM in Chinese Han population.

Cross-sectional association of serum C-reactive protein and uric acid with albuminuria in Chinese type 2 diabetic patients

Background Evidences show that subclinical chronic inflammation is involved in the pathogenesis of diabetic nephropathy. The aim of this study was to examine the relationship between serum C-reactive protein （CRP）, serum uric acid, and albuminuria in Chinese type 2 diabetic patients.

6q24 transient neonatal diabetes mellitus： the first case report from China

To the editor： Neonatal diabetes mellitus （NDM） is one kind of monogenic diabetes which usually presents within 6 months after birth and needs insulin treatment for at least 2 weeks.1 For transient neonatal diabetes mellitus （TNDM）, all patients will go into remission phase but nearly half the patients have the risk of developing diabetes again.2 About 70% ofaU TNDM is 6q24 TNDM, which is related to imprint disorder causing hypomethylation on chromosome 6q24.3 General progression and treatment are similar in 6q24 TNDM patients. Insulin treatment usually no more than 18 months is needed at presentation, and sulfonylureas （SUs） can be chosen during relapse.3＇4 Out of rarity of the disease, until now no case report including detailed clinical data has ever been published before in China. Here we report the first case of 6q24 TNDM diagnosed as paternal uniparental disomy （patUPD）, in which homologous chromosomes of chromosome 6 are both paternal origin, resulting from the mistake in meiosis or mitosis.

Propylthiouracil induced antineutrophil cytoplasmic antibodies-associated vasculitis

To the editor： Antineutrophil cytoplasmic antibodies （ANCA） are a group of autoantibodies associated with various diseases andcan be detected in drug-induced vasculitides. Here, we report two patients of drug-induced vasculitides combind with kidney damage （one is followed-up 10 years, the other is followed-up 3 years） and review the literature for the occurrence of this complication, share the common phenomenon with our peers.

Efficacy and safety of insulin treatment in type 2 diabetes using a new index called glucose safety control index

Objective To recommend an index named glucose safety control index （GSCI） to evaluate the efficacy and safety for insulin regimens. Data sources We searched databases for primary studies published in English. The main search concepts were type 2 diabetes, insulin treatment, premixed insulin, premixed insulin analogs, basal inuslin, basal inuslin analogs, bolus insulin, bolus insulin analogs, safety and efficacy.

On the mechanism of metformin-inhibited hepatic gluconeogenesis

Objective To investigate the underlying molecular mechanisms of metformin in inhibiting hepatic gluconeogenesis.Methods Primary hepatocytes of mice were isolated by a modified version of the collagenase method.The effect of metformin on glucose production in primary hepatocytes was detected by glucose oxidation method.

Correlation between serum LPA/OPN and TGF-β1 in type 2 diabetic patients with different urinary albumin/creatinine ratio

Objective To investigate the correlation between serum lysophosphatidic acid(LPA),osteopontin(OPN)and transforming growth factor-β1(TGF-β1)in patients with type 2 diabetes mellitrus(T2DM)and different urinary albumin/creatinine ratio(UACR).Methods A total of 313 patients with T2DM were enrolled in the Department of Endocrinology and Metabolism of The First Affiliated Hospital of China Medical University from March 2018 to December 2019.

Lower grade chronic inflammation is associated with obstructive sleep apnea syndrome in type 2 diabetes mellitus

Objective To investigate whether the existence of obstructive sleep apnea syndrome(OSAS)in patients with type 2 diabetes(T2DM) is associated with low grade chronic inflammation.Methods Fifty-four patients hospitalized for poor glycemic control from 12/2008 to 12/2009 were divided into 2 groups,OSAS group(T2DM with OSAS,27 cases)and NOSAS group(T2DM without OSAS,27 cases).The control group consisted of 26people from a health check-up program without

Effect of four different anti-osteoporosis agents on the expression of matrix gla protein in primary osteoblasts of SD rat

Objective To observe the expression of matrix gla protein(MGP) mRNA in primary osteoblasts of Sprague-Dawley(SD) rat in vitro after treatment with anti-osteoporosis agents[vitamin K2,PTH,1,25(OH)2D3,and alendronate],and to investigate the potential role of MGP