Objective To find a new source of hematopoietic stem cell and investigate the availability of no-genetic -connection cord blood transplantation in treatment of pediatric lymphoma. Methods The patient was treated by al...Objective To find a new source of hematopoietic stem cell and investigate the availability of no-genetic -connection cord blood transplantation in treatment of pediatric lymphoma. Methods The patient was treated by allogenic cord blood stem cell transplantation. After the all circumstance had been protected, high-dose chemotherapy was applied in addition to total body irradiation. The pretreatment protol included: Cyclophosphamide 120 mg/kg + Etoposide 18 mg/kg + rabbit-anti-human thymus IgG 2.5 mg/kg every day × 3 days + total body irradiation 8 Gy. Then 52 ml of A-type (ABO) and a HLA-site cord incoincidence blood was infused. For prevention of graft verse host disease (GVHD), anti-human thymus globulin, cyclosporin A, methotrexate were intravenously infused. After transplantation, clinical characters and laboratory examinations including blood routine, T3, T4, AFP were examined. Results After transplantation, thehematopoietic function was reconstructed, ANC】0.5 × 109/L after 33 days, and PLT 】展开更多
文摘Objective To find a new source of hematopoietic stem cell and investigate the availability of no-genetic -connection cord blood transplantation in treatment of pediatric lymphoma. Methods The patient was treated by allogenic cord blood stem cell transplantation. After the all circumstance had been protected, high-dose chemotherapy was applied in addition to total body irradiation. The pretreatment protol included: Cyclophosphamide 120 mg/kg + Etoposide 18 mg/kg + rabbit-anti-human thymus IgG 2.5 mg/kg every day × 3 days + total body irradiation 8 Gy. Then 52 ml of A-type (ABO) and a HLA-site cord incoincidence blood was infused. For prevention of graft verse host disease (GVHD), anti-human thymus globulin, cyclosporin A, methotrexate were intravenously infused. After transplantation, clinical characters and laboratory examinations including blood routine, T3, T4, AFP were examined. Results After transplantation, thehematopoietic function was reconstructed, ANC】0.5 × 109/L after 33 days, and PLT 】
