A comparative study of gastrointestinal gas volume in patients with functional dyspepsia based on abdominal computed tomography and gas volume score

Objective To compare the difference between gas volume score (GVS) method and combination of computed tomography (CT) image and calculation formula method (hereinafter referred to as CT method)in the detection of gastrointestinal gas volume in functional dyspepsia (FD) patients.

Efficacy of high-dose dual therapy for Helicobacter pylori infection eradication in servicemen:a randomized controlled trial

Objective To assess the efficacy and costeffectiveness of high-dose dual therapy compared with bismuth-containing quadruple therapy for treating Helicobacter pylori(H.pylori)infection in servicemen patients.Methods A total of 160 H.pylori-infected,treatment-naive servicemen,including 74 men and 86women,aged from 20 years to 74 years,with a mean(SD)age of 43(13)years,tested in the First Center of Chinese PLA General Hospital from March 2022 to May2022 were enrolled in this open-label,randomized controlled clinical trial.

Risk factors of gastrointestinal polypectomy concurrent with bleeding in patients with liver cirrhosis

Objective To investigate and analyze the occurrence and the related risk factors of gastrointestinal polypectomy accompanied by bleeding in patients with liver cirrhosis.Methods 127 cases of gastrointestinal polyps with cirrhosis who had endoscopy at the Endoscopic Center of Tianjin Third Central Hospital between November 2017 and November 2020 were collected.

The correlation between HBeAg levels and entecavir long-term efficacy in chronic hepatitis B patients

Objective To study the correlation between HBeAg levels and the efficacy of entecavir long-term treatment in chronic hepatitis B(CHB) patients. Methods Fifty-nine HBeAg-positive CHB patients were divided into three groups according to baseline HBeAg levels:Group A(n=19,HBeAg≥1000s/co),

Diagnosis of hepatic fibrosis in hepatitis B patients by logistic regression modeling based on plasma amino acid ratio and age

Objective To explore the efficacy of logistic regression modeling based on plasma amino acid profile and patient age,for diagnosing hepatic fibrosis in patients with chronic hepatitis B (CHB) .Methods One-hundredand-forty-eight patients (108 males;mean age:38.1±11.9 years,range:16—72 years)

Noninvasive assessment of esophageal-gastric varices by spleen stiffness in liver cirrhosis patients

Objective To investigate the value of spleen stiffness measured by transient elastography(FibroScan,FS) for diagnosing esophageal-gastric varices in liver cirrhosis patients. Methods A total of 259 cirrhotic patients in Tianjin Third Central Hospital rom Apr 2011 to Apr 2012,and 30 healthy controls were

Potential mechanism of microRNA in hepatitis B virus infection by using genechip and public database data

Objective To investigate the potential mechanism of microRNA(miRNA)in hepatitis B virus(HBV)infection.Methods The peripheral blood samples were collected from four chronic hepatitis B(CHB)patients who visited Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017,and those were also collected from four healthy controls.Affymetrix GeneChip microRNA 4.0 was applied to detect the expressions of miRNA between CHB patients and healthy controls.

Clinical study of highly active antiretroviral therapy combined with Jianpi Yishen decoction on TCM syndrome and CD4^(+)T cells in asymptomatic stage of AIDS

Objective To observe the effects of highly active anti-retroviral therapy (HAART) combined with the Jianpi Yishen Decoction on the Chinese medical syndrome score and CD4^(+)T lymphocyte count in asymptomatic stage in patients with AIDS.Methods A total of 60 asymptomatic AIDS patients were included in this study and assigned to control group and treatment group (30 cases,respectively) by random number table.

A clinical investigation of patients with functional gastrointestinal disorders complicated with sleep disorders

Objective To analyze the status of sleep disorders in patients with functional gastrointestinal disease(FGID)and its relation with symptom characteristics.Methods From January to December 2014,questionnaire was carried out in FGID patients who met the Rome Ⅲ criteria and visited the outpatient department of gastroenterology at six third-level general hospitals in Tianjin City to assess the severity of symptoms,sleep quality(Pittsburgh sleep quality index,PSQI),and psychological state(anxiety and depression).Chi-square test and Mann-Whitney rank sum test were performed for statistical analysis.Results Among 931 patients with FGID,651(69.92%)patients had sleep disorders and 280(30.08%)patients had no sleep disorders.Among 828 patients with functional dyspepsia(FD),360(43.48%)patients had sleep disorders complicated with and depression.Among 292 patients with irritable bowel syndrome(IBS),138(47.26%)had sleep disorders complicated with anxiety and depression.Among 618 patients with FD complicated with sleep disorders,70(11.33%)patients overlapped with IBS;among 210 patients with FD,but without sleep disorder,11(5.24%)patients overlapped with IBS and the percentage of the former was higher than the latter,and the difference was statistically significant(X^2=6.580,P=0.01).The proportion of lower abdominal pain,sheep fecal or hard stool,laborious defecation or incomplete defecation in FGID patients without sleep disorder were 22.14%(62/280),11.79%(33/280),19.29%(54/280)and 27.86%(78/280),respectively;which were lower than those of FGID patients with sleep disorders(36.10%(235/651),21.20%(138/651),32.41%(211/651)and 44.39%(289/651));and the differences were statistically significant(X^2=17.552,11.569,16.566 and 22.419;all P<0.01).FGID patients with sleep disorders had more severe symptoms such as lower abdominal pain,lower abdominal discomfort(non-pain),sheep fecal or hard stool,laborious defecation incomplete defecation,and urgency than FGID patients without sleep disorders;and the differences were statistically significant(Z=-4.423,-1.973,-3.360,-4.467,-4.550 and-2.420;all P<0.05).Conclusion Sleep disorders,anxiety and depression often coexist in patients with FGID.Sleep disorders are closely related with lower gastrointestinal symptoms in patients with FGID.

The robot-assisted system Yun SRobot for soft endoscopy: a trial of remote manipulation on simulation models

Objective To evaluate the feasibility and safety of the robot-assisted system YunSRobot for remote manipulation endoscopy. Methods When the master of YunSRobot was installed in the gastroenterology office in Chinese PL A General Hospital, the robot slave and upper gastrointestinal simulation model ( Takahashi Lm 103, Japan ) were installed at the same time in the State Key Laboratory of Robotics.

The clinical characteristics and risk factors for acute kidney injury in patients with cirrhosis

Objective To investigate the clinical features and risk factors for acute kidney injury (AKI) in patients with cirrhosis. Methods A total of 1165 hospitalized patients with chronic liver diseases were enrolled. Among them , 94 patients had chronic hepatitis, while 1 071 patients were diagnosed as cirrhosis. The clinical data, renal and liver function were retrospectively analyzed.

Sodium butyrate affects the proliferation and apoptosis of steatosis HepG2 cells via G proteincoupled receptor 43/109a-phosphorylated protein kinase B-mammalian target of rapamycin signaling pathway

Objective To investigate the effects and mechanism of gut metabolite sodium butyrate on the proliferation and apoptosis of steatosis HepG2 cellsin vitro.Methods The in vitrosteatosis hepatocyte model was established with human liver cell line HepG2 and free fatty acid(FFA;the concentration ratio of oleic acid to palmitic acid was 2∶1).

Prognostic Nomogram model for the efficacy of endoscopic treatment in gastric varices caused by liver cirrhosis

Objective To predict the efficacy of endoscopic tissue adhesives in the treatment of gastric varices in patients with liver cirrhosis by Nomogram model.Methods From August 2014 to September 2017,158 patients with liver cirrhosis caused esophagogastric variceal bleeding and received endoscopic tissue adhesives treatment at Zhongshan Hospital,Fudan University were collected.All patients were followed for 12 months.

Study on the susceptibility genes that mediate the resistance of Helicobacter pylori to clarithromycin and levofloxacin based on comprehensive antibiotic research database comparison

Objective To explore the new genes related to the resistance of H. pylori to clarithromycin (CLA) and levofloxacin (LVX) based on whole-genome sequencing.Methods From September 1st, 2016 to August 31st,2019, 1 749 patients with upper gastrointestinal symptoms and positive13C urea breath test who visited the Department of Gastroenterology and Hepatology, the University of Hong Kong-Shenzhen Hospital were enrolled.

Distribution of food specific antibodies in patients with inflammatory bowel disease

Objective To investigate the incidence of food intolerance in patients with inflammatory bowel disease(IBD)and to analyze the differential diagnostic value of intolerant food in Crohn’s disease(CD)and ulcerative colitis(UC)and its effects on the diseases.

Efficacy and safety of the combination of agomelatine and low-dose olanzapine in 184 cases of postprandial distress syndrome with depression,anxiety and sleep disorders

Objective To observe the efficacy and safety of the combination of agomelatine and low-dose olanzapine(AO)in the treatment of postprandial distress syndrome(PDS)with depression,anxiety and sleep disorders.Methods From April 2019 to September 2020,PDS patients with depression,anxiety and sleep disorders in Tianjin Medical University General Hospital were selected and divided into AO group and flupentixol-melitracen(FM)group.

Therapeutic effect of endoscopic anterior fundoplication by MUSE^(TM) in thirteen patients with gastroesophageal reflux disease

Objective To evaluate the efficacy and safety of endoscopic anterior fundoplication by the MUSETM endoscopic stapling device in gastroesophageal reflux disease (GERD). Methods From March to November 2017 , in the Department of Gastroenterology of Chinese PLA eral Hospital in Beijing.