Bushen Huoxue recipe inhibited vascular calcification in chronic renal failure rats by regulating BMP-2 / Runx2 / Osterix signal pathway

Objective To observe the effect of Bushen Huoxue Recipe(BHR)on inhibiting vascular calcification(VC)in chronic renal failure(CRF)rats by regulating BMP-2/Runx2/Osterix signal pathway,and to explore its possible mechanism.Methods Thirty SD rats were randomly divided into the normal group,the model group,and the BHR group,10 in each group.Rats in the model group and the BHR group were administered with 250

Effect of modified Hangqi Chifeng decoction containing serum on the expression of Col Ⅳ,MMP-2,and TIMP-2 in glomerular mesangial cells induced by LPS

Objective To explore the effect of Modified Hangqi Chifeng Decoction(MHCD)on levels of collagen typeⅣ(ColⅣ),matrix metalloproteinase-2(MMP-2),tissue inhibitor of metalloproteinase-2(TIMP-2)in extracellular matrix(ECM)of glomerular mesangial cells(GMCs)in LPS induced mice.Methods Normal serum and telmisartan,high,medium,low dose MHCD containing

Relationship between islet α-cell function and glomerular filtration rate in type 2 diabetic patients

Objective To analyze the isletα-cell function in type 2 diabetic patients with different levels of glomerular filtration rate (eGFR) .Methods Three hundred and eighty-eight cases of type 2 diabetic patients were classified into four groups according to eGFR:glomerular hyperfiltration group,normal renal function group,mild renal dysfunction group and moderate-severe renal dysfunction group.Oral glucose tolerance test,insulin releasing test and glucagon releasing test were conducted to