Objective To investigate the feasibility of 99Tcmhydrazinonicotinamide-(poly-(ethylene glycol))4-E[(poly-(ethylene glycol))4-c((Arg-Gly-Asp)fK)]2(3PRGD2)in the early diagnosis of rheumatoid arthritis(RA).Methods Sixty...Objective To investigate the feasibility of 99Tcmhydrazinonicotinamide-(poly-(ethylene glycol))4-E[(poly-(ethylene glycol))4-c((Arg-Gly-Asp)fK)]2(3PRGD2)in the early diagnosis of rheumatoid arthritis(RA).Methods Sixty female Wistar rats were divided into control group(n=10;injected with saline of0.3 ml/piece)and collagen-induced arthritis(CIA)group(n=50;injected with type Ⅱ collagen emulsion of 0.3 ml/piece).Rats in 2 groups were subjected to 99Tcm-3PRGD2 planar imaging before modeling,25 and 45 d after modeling.展开更多
文摘Objective To investigate the feasibility of 99Tcmhydrazinonicotinamide-(poly-(ethylene glycol))4-E[(poly-(ethylene glycol))4-c((Arg-Gly-Asp)fK)]2(3PRGD2)in the early diagnosis of rheumatoid arthritis(RA).Methods Sixty female Wistar rats were divided into control group(n=10;injected with saline of0.3 ml/piece)and collagen-induced arthritis(CIA)group(n=50;injected with type Ⅱ collagen emulsion of 0.3 ml/piece).Rats in 2 groups were subjected to 99Tcm-3PRGD2 planar imaging before modeling,25 and 45 d after modeling.
