Prediction models for respiratory event types in OSA patients based on hypoxic parameters

Objective To analyze the hypoxic parameters in patients with obstructive sleep apnea (OSA),to explore the difference and association between different types of respiratory events and to construct predictive models for respiratory event types.Methods Fifty patients [including41 males and 9 females with age 18-74 (45.72±13.39) years] with OSA diagnosed by polysomnography(PSG) were selected for retrospective analysis.

Clinical analysis of lung adenocarcinoma with epidermal growth factor receptor mutation transformed into sarcoma

Objective To analyze the clinical data of a case of lung adenocarcinoma with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)resistance transforming into sarcoma,and to conduct a literature review to improve the understanding of the resistance mechanism.Histological transformation is a unique form of acquired resistance of EGFR-TKIs in non-small cell lung cancer (NSCLC).

Relationship between respiratory event-related arousal and increased pulse rate in patients with obstructive sleep apnea

Objective To investigate the relationship between respiratory event-related arousal and increased pulse rate in patients with obstructive sleep apnea(OSA),and to evaluate whether elevated pulse rate can be used as a surrogate marker of arousal.Methods A total of 80patients[40 males and 40 females,age range(18-63years),mean age(37±13)years]who attended the Sleep Center of the Department of Respiratory and Critical Care Medicine,Tianjin Medical University General Hospital for polysomnography(PSG)from January 2021 to August 2022 were enrolled.

Safety of umeclidinium/vilanterol in Chinese patients in a real-world setting:a prospective,multicenter,single-arm,observational study

Objective To evaluate the safety of umeclidinium/vilanterol in Chinese participants in a real-world setting.Methods This was a 24-week,prospective,multicenter,single-arm,observational study that enrolled participants treated with umeclidinium/vilanterol in real-world settings from 14 sites in China from 14 December 2020 to 30 January 2022.

Correlation between arousal threshold and occurrence of hypertension in patients with obstructive sleep apnea hypopnea syndrome

Objective To investigate the relationship between arousal threshold (ArTH) and hypertension in patients with obstructive sleep apnea hypopnea syndrome (OS A).Methods This study recruited 648 patients diagnosed with OSA at the Sleep Center of the Second Affiliated Hospital of Soochow University from January 2020 to August 2021,including 569 males and 79 females,aged 42(35,52) years.

Hemodynamic changes with serial balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension

Objective To monitor hemodynamic changes during serial balloon pulmonary angioplasty (BPA) for chronic thromboembolic pulmonary hypertension (CTEPH).Methods General clinical data of CTEPH patients diagnosed from October 2017 to January 2022 in Beijing Chaoyang Hospital were collected,and 83 patients who underwent at least 1 BPA treatment were included to analyze their 6 min walking distance,WHO functional class,N-terminal B-type natriuretic peptide precursor(NT-proBNP),troponin I (cTnI) and haemodynamic indices.

Effect of SHP-1 knockout in airway epithelial cells on emphysema phenotype in chronic obstructive pulmonary disease in mice

Objective To construct and characterize conditional Src homology region 2 protein tyrosine phosphatase 1(SHP-1)knockout mice in airway epithelial cells and to observe the effect of defective SHP-1 expression in airway epithelial cells on the emphysema phenotype in chronic obstructive pulmonary disease(COPD).Methods To detect the expression of SHP-1 in the airway epithelium of COPD patients,CRISPR/Cas9 technology was used to construct SHP-1flox/flox transgenic mice,which were mated with airway epithelial Clara protein 10-cyclase recombinase and estrogen receptor fusion transgenic mice(CC10-CreER^(+/+)),and after intraperitoneal injection of tamoxifen,airway epithelial SHP-1 knockout mice were obtained(SHP-1^(max/fox) CC10-CreER^(+/+),SHP-1^(Δ/Δ)).

Effects of proton pump inhibitors on stress ulcers in elderly patients with acute respiratory distress syndrome

Objective To analyze the effects of proton pump inhibitors (PPIs) on the prevention of stress ulcers (SU)in elderly patients with acute respiratory distress syndrome (ARDS),and to analyze related factors for the risk of short-term death.Methods This study was amulticenter retrospective cohort study.

A survey on the application of diagnostic and evaluation tools for chronic obstructive pulmonary disease among respiratory physicians

Objective To investigate the current status of the application of diagnostic and assessment tools for chronic obstructive pulmonary disease (COPD) by respiratory physicians in China.Methods An on-line questionnaire was designed to address the common questions in COPD diagnosis and evaluation, and this survey was conducted through Wechat.Results A total of 3 204 valid questionnaires were collected. 71.7%of the physicians were from tertiary hospitals.

Clinical characteristics of 288 cases of pathologically confirmed benign pulmonary nodules post-surgery

Objective To analyze retrospectively the clinical characteristics of pathologically confirmed benign pulmonary nodules post-surgery,and therefore to provide evidence for the diagnosis of benign pulmonary nodules.Methods 288 cases of pulmonary nodules were selected in the Ruijin Hospital from 1 st January 2017 to 31 st October 2019.All the lesions of these patients were confirmed by surgery and had definite pathological diagn sis.The clinical data were collected.

Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia

Objective To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP).Methods 30 patients infected with novel coronavirus referred to Jianghan university hospital between January 11,2020 and January 3,2020 were studied.The data reviewed included those of clinical manifestations,laboratory investigation and radiographic features.

Continuous positive airway pressure therapy affects the recurrence of atrial fibrillation in patients with obstructive sleep apnea:a systematic review and meta-analysis

Objective A higher incidence of atrial fibrillation is associated with obstructive sleep apnea.The effects of continuous positive airway pressure on atrial fibrillation have been studied in observational studies and randomized controlled trials.We therefore conducted this meta-analysis to assess the effect of continuous positive airway pressure on the recurrence of atrial fibrillation after radiofrequency ablation.

A long-term follow-up study of noninvasive positive pressure ventilation on all-cause mortality in patients with chronic obstructive pulmonary diseaseobstructive sleep apnea overlap syndrome

Objective To investigate the effect of noninvasive positive pressure ventilation(NIPPV)on all-cause mortality in patients with chronic obstructive pulmonary disease-obstructive sleep apnea overlap syndrome(OvS)through long-term follow-up.Methods A total of 187 OVS patients were divided into the NIPPV group(n=92)and the non-NIPPV group(n=95).

Clinical characteristics and prognostic factors of patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis associated interstitial lung disease

Objective To analyze the clinical characteristics and prognostic factors of patients with anti-melanoma differentiation-associated gene 5(anti-MDA5)-positive dermatomyositis associated interstitial lung disease(DMILD).Methods The patients with MDA5~+DM-ILD who were admitted to Department of Respiratory Medicine,Nanjing Drum Tower Hospital from January 2017 to March 2021 were enrolled.The clinical data and survival information were analyzed retrospectively.

Protective effect of intervention with cannabinoid type-2 receptor agonist JWH133 on pulmonary fibrosis in mice

Objective JWH133,a cannabinoid type 2 receptor agonist,was tested for its ability to protect mice from bleomycin-induced pulmonary fibrosis.Methods By using a random number generator,24 C57BL/6J male mice were randomly divided into the control group,model group,JWH133 intervention group,and JWH133+a cannabinoid type-2 receptor antagonist(AM630)inhibitor group,with 6 mice in each group.A mouse pulmonary fibrosis model was established by tracheal instillation of bleomycin(5 mg/kg).

Effect of sleep spindle density on memory function in patients with obstructive sleep apnea hypopnea syndrome

Objective To explore the characteristics of sleep spindle density in nonrapid eye movement(NREM)stage2(N2)sleep and its effect on memory function in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Patients who underwent polysomnography(PSG)examination due to snoring in the Second Affiliated Hospital of Soochow University from January to December 2021 were prospectively collected.

Effect of obstructive sleep apnea on the severity of acute pulmonary thromboembolism

Objective To investigate the effect of obstructivesleep apnea (OSA) on the severity of acute pulmonarythromboembolism (PTE). Methods Clinical data of patientswith acute PTE and OSA who were admitted toAnzhen Hospital from January 2015 to December 2017were retrospectively analyzed in this study. According tothe apnea hypopnea index (AHI),patients were dividedinto AHI≤15 /h group and AHI > 15 /h group. The levelsof oxygen desaturation index (ODI),mean pulse oxygensaturation (MSO2),the lowest pulse oxygen saturation( LSaO2), oxygen saturation < 90% time ratio(Ts 90%), hemoglobin, hematocrit ( HCT ), bloodplatelet,mean platelet volume (MPV),platelet distributionwidth ( PDW),hypersensitive C-reactive protein(hsCRP),homocysteine ( HCY),prothrombin time,activated partial thromboplastin time (APTT),fibrinogen(FIB),D-dimer,fibrin degredation product (FDP),Btypenatriuretic peptide,cardiac troponin I ( cTnI),arterialpartial pressure of oxygen (PaO2),arterial partialpressure of carbon dioxide (PaCO2) were compared betweenAHI≤15 /h group and AHI > 15 /h group. Differencesin the severity of PTE between the two groups werecompared;binary Logistic regression model was used toanalyze the risk factors of acute PTE severity.

Epidemiological characteristics of novel coronavirus pneumonia in Shijiazhuang,China

Objective To analyze the epidemiological characteristics of an outbreak of novel coronavirus pneumonia(COVID-19)in Shijiazhuang,Hebei Province in 2021 and to provide scientific basis for developing improved strategies to prevent and control the outbreak of COVID-19.Methods Descriptive analysis of the outbreak of COVID-19 in Shijiazhuang,Hebei Province was performed with SPSS 21.0 and Excel software.

Clinical characteristics and prognosis of elderly patients with malignant tumors complicated with venous thromboembolism

Objective To analyze the clinical features and prognosis of elderly patients with malignant tumors complicated with venous thromboembolism (VTE).Methods The clinical data of 280 patients with malignant tumors and VTE hospitalized in Beijing Hospital from January 2003 to January 2013 were retrospectively analyzed.The clinical features and prognosis were analyzed and compared between the elderly and non-elderly groups.

A preliminary investigation of the clinical characteristics of community acquired pneumonia concomitant with pulmonary embolism

Objective To understand the clinical characteristics of patients with pneumonia concomitant with acute pulmonary embolism, and to early identifiy high-risk patients.Methods Retrospective analysis of hospitalized patients with confirmed diagnosis of community acquired pneumonia(CAP) concomitant with pulmonary embolism(PE) of 5 years was conducted.