The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen transmission.While modeling efforts have recently explored how within-host dynamic...The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen transmission.While modeling efforts have recently explored how within-host dynamics contribute to shaping population transmission,fewer have explored how ongoing circulation of an epidemic infectious disease can impact within-host immunological dynamics.We present a simple,influenza-inspired model that explores the potential for re-exposure during a single,ongoing outbreak to shape individual immune response and epidemiological potential in non-trivial ways.We show how even a simplified system can exhibit complex ongoing dy-namics and sensitive thresholds in behavior.We also find epidemiological stochasticity likely plays a critical role in reinfection or in the maintenance of individual immunological protection over time.展开更多
基金supported in part by the Mathematics and Climate Research Network and AIM through NSF award DMS-1722578the Clare Boothe Luce Program through Boston University,with additional support from Bowdoin College.
文摘The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen transmission.While modeling efforts have recently explored how within-host dynamics contribute to shaping population transmission,fewer have explored how ongoing circulation of an epidemic infectious disease can impact within-host immunological dynamics.We present a simple,influenza-inspired model that explores the potential for re-exposure during a single,ongoing outbreak to shape individual immune response and epidemiological potential in non-trivial ways.We show how even a simplified system can exhibit complex ongoing dy-namics and sensitive thresholds in behavior.We also find epidemiological stochasticity likely plays a critical role in reinfection or in the maintenance of individual immunological protection over time.
