AIM To investigate the expression change of α-synuclein in the brain of different age AD-like an-imal model and to explore the pathology mechanism of α-synuclein in neural degeneration and protective effect of 2 kin...AIM To investigate the expression change of α-synuclein in the brain of different age AD-like an-imal model and to explore the pathology mechanism of α-synuclein in neural degeneration and protective effect of 2 kinds of Chinese components. METHODS A generally accepted animal model of Alzheimer' s disease-APP V717I transgenic (Tg) mouse was observed from 4 to 16 month old. The Tg mice wererandomly divided into model group(4 month, 10 month and 16 month old), Shen-wu capsule with the dose of 0.4g and 1.2g/kg/d, 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside(TSG), one of effective components in Polygonum muhiflorum, at dose of 0. 05,0.1 and 0.2g/kg/d.展开更多
文摘AIM To investigate the expression change of α-synuclein in the brain of different age AD-like an-imal model and to explore the pathology mechanism of α-synuclein in neural degeneration and protective effect of 2 kinds of Chinese components. METHODS A generally accepted animal model of Alzheimer' s disease-APP V717I transgenic (Tg) mouse was observed from 4 to 16 month old. The Tg mice wererandomly divided into model group(4 month, 10 month and 16 month old), Shen-wu capsule with the dose of 0.4g and 1.2g/kg/d, 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside(TSG), one of effective components in Polygonum muhiflorum, at dose of 0. 05,0.1 and 0.2g/kg/d.
