Objective: To investigate the effect of electroacupuncture (EA) on aconit ine-ind uced ventricular tachyarrhythmia. Methods: Twenty SD rats anesthe tized with chlo ral hydrate (300 mg/kg, i.p.) were evenly and randoml...Objective: To investigate the effect of electroacupuncture (EA) on aconit ine-ind uced ventricular tachyarrhythmia. Methods: Twenty SD rats anesthe tized with chlo ral hydrate (300 mg/kg, i.p.) were evenly and randomly divided into control and EA groups. Ventricular arrhythmia was induced by intravenous infusion of 0.001% a conitine (i.v., 3.5 mg/kg, 0.4 mL/min). EA (4～16 Hz, 1～3 V) was applied to "N eiguan "(内关 PC 6) and "Jianshi"(间使 PC 5) for 30 min. ECG was recorded and analyz ed to deter mine ventricular premature beat (VPB), ventricular tachycardia (VT) and ventricu lar fibrillation (VF). Results: EA elevated the dose threshold o f aconitine-indu ced VF (P<0.05), delayed the occurrence of VT and VF (P <0.01), prolonged the sur vival time and reduced the mortality of rats treated with aconitine (P< 0.01). Conclusion: EA can suppress aconitine-induced ventricular tachyarr hythmia.展开更多
文摘Objective: To investigate the effect of electroacupuncture (EA) on aconit ine-ind uced ventricular tachyarrhythmia. Methods: Twenty SD rats anesthe tized with chlo ral hydrate (300 mg/kg, i.p.) were evenly and randomly divided into control and EA groups. Ventricular arrhythmia was induced by intravenous infusion of 0.001% a conitine (i.v., 3.5 mg/kg, 0.4 mL/min). EA (4～16 Hz, 1～3 V) was applied to "N eiguan "(内关 PC 6) and "Jianshi"(间使 PC 5) for 30 min. ECG was recorded and analyz ed to deter mine ventricular premature beat (VPB), ventricular tachycardia (VT) and ventricu lar fibrillation (VF). Results: EA elevated the dose threshold o f aconitine-indu ced VF (P<0.05), delayed the occurrence of VT and VF (P <0.01), prolonged the sur vival time and reduced the mortality of rats treated with aconitine (P< 0.01). Conclusion: EA can suppress aconitine-induced ventricular tachyarr hythmia.
