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In Memory of Our Beloved Friend Prof. Jouni Uitto, an Internationally Recognized Dermatologist
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作者 《International Journal of Dermatology and Venereology》 CSCD 2023年第1期60-60,共1页
We sadly heard of the passing away of Prof.Jouni Uitto,a renowned dermatologist and chair of the Department of Dermatology&Cutaneous Biology at Thomas Jefferson University,USA,on December 17,2022,at the age of 79.... We sadly heard of the passing away of Prof.Jouni Uitto,a renowned dermatologist and chair of the Department of Dermatology&Cutaneous Biology at Thomas Jefferson University,USA,on December 17,2022,at the age of 79.The international dermatology community has lost a great master and Chinese dermatologists have lost a beloved friend forever. 展开更多
关键词 has HEAR PASSING
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门诊疑似患者人乳头瘤病毒检测及基因亚型分布 被引量:2
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作者 张胜 李凌佳 +4 位作者 王杨 彭传梅 陈婉婷 卫波 郭紫轩 《中国皮肤性病学杂志》 CAS CSCD 北大核心 2016年第10期1033-1036,共4页
目的了解我院门诊疑似患者人乳头瘤病毒(HPV)感染情况及其基因亚型分布情况。方法回顾性分析2014年1月-2015年12月本院门诊疑似HPV感染者临床资料及其基因亚型检测结果,比较不同性别、季节和年龄组HPV感染特点及其基因亚型分布情况... 目的了解我院门诊疑似患者人乳头瘤病毒(HPV)感染情况及其基因亚型分布情况。方法回顾性分析2014年1月-2015年12月本院门诊疑似HPV感染者临床资料及其基因亚型检测结果,比较不同性别、季节和年龄组HPV感染特点及其基因亚型分布情况。结果9154例门诊疑似HPV感染患者中,HPV阳性2125例(23.21%),其中男93例(4.38%),女2032例(95.62%)。低危亚型以HPV6和HPV81检出率最高,男分别为15.56%和8.89%,女分别为16.42%,11.58%;高危亚型以HPV52,16和58型检出率最高,男分别为22.73%,16.67%和12.02%,女分别为20.42%,14.74%和8.11%。31~40岁为感染最高峰,21~50岁组HPV检出率明显高于其他年龄组HPV检出率,差异均有统计学意义(P均〈0.05)。单一HPV亚型感染1416例(72.99%),高危型HPV感染1268例(65.36%),HPV感染主要流行于春季(尤其3月和4月)与夏季(特别是7月和8月)。结论我院门诊就诊人群HPV感染率较高,以中青年女性为著,呈单一高危型HPV感染,应提高疑似HPV感染高危人群季节性筛检力度与范围。 展开更多
关键词 人乳头瘤病毒 基因 流行病学
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Clinical variants of pityriasis rosea 被引量:3
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作者 Francisco Urbina Anupam Das Emilio Sudy 《World Journal of Clinical Cases》 SCIE 2017年第6期203-211,共9页
Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR... Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Variants of the disease in some cases may be troublesome to diagnose and confuse clinicians. Prompt diagnosis and treatment of the condition becomes necessary to avoid unnecessary investigations. We hereby review and illustrate atypical presentations of the disease, including diverse forms of location and morphology of the lesions, the course of the eruption, and its differential diagnoses. 展开更多
关键词 PITYRIASIS PITYRIASIS rosea PITYRIASIS rosea of Gibert HERALD PATCH Papulo-squamous DERMATOSIS
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探析针灸医籍中头痛论述 被引量:8
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作者 焦恩虎 陈易 +1 位作者 孟建霞 徐琬梨 《天津中医药大学学报》 CAS 2019年第3期237-240,共4页
通过挖掘整理针灸医籍中关于头痛论述,探讨其理论基础、诊疗方案及临床价值。关于头痛的论述,多散在于《黄帝内经》《针灸大成》《针灸逢源》等医籍,涵盖了病因、辨证、四诊、治疗、预后、禁忌等多个方面。提出了风、寒、湿、热、伏发... 通过挖掘整理针灸医籍中关于头痛论述,探讨其理论基础、诊疗方案及临床价值。关于头痛的论述,多散在于《黄帝内经》《针灸大成》《针灸逢源》等医籍,涵盖了病因、辨证、四诊、治疗、预后、禁忌等多个方面。提出了风、寒、湿、热、伏发发病、阴阳失调的关键病因,经脉、脏腑辨证角度,四诊诊疗手段,针刺手法取穴的治疗方案,预后、禁忌是判别、指导疾病康复的关键环节。文章为头痛的认识提供了较为全面的认识,有着深刻的影响,并为临床诊治工作提供了可靠依据。 展开更多
关键词 针灸医籍 头痛 探析
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Susceptibility to Fluconazole and Ketoconazole of Candida spp. Isolated from Primary and Episodic Vulvovaginites by E-Test (São Paulo, SP, Brazil) 被引量:1
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作者 Humberto Fabio Boatto Manoel João Batista Castello Girão +3 位作者 Elaine Cristina Francisco Alexandre Paulo Machado Maria Sayonara de Moraes Olga Fischman 《Open Journal of Obstetrics and Gynecology》 2016年第12期689-697,共10页
Purpose: To evaluate the profile of in vitro susceptibility of yeasts isolated from cases of primary and espisodic vulvovaginitis to two antifungal agents. Methods: 40 Candida isolates from episodes of vulvovaginal ca... Purpose: To evaluate the profile of in vitro susceptibility of yeasts isolated from cases of primary and espisodic vulvovaginitis to two antifungal agents. Methods: 40 Candida isolates from episodes of vulvovaginal candidiasis were identified by classic methodologies. The susceptibility testing of the in vitro fluconazole and ketoconazole activity against the isolates was accessed by E-test. Results: C. albicans was the most common species identified in 70% of the occurrences followed by C. glabrata (20%), C. tropicalis (7.5%), and C. guilliermondii (2.5%). In the susceptibility profile to antifungal agents, 12.5% and 16.7% of the isolates obtained from primary and episodic vulvovaginal candidiasis were resistant to fluconazole, respectively. To ketoconazole, we found that 6.25% and 12.5% of the isolates respectively from primary vulvovaginal candidiasis (PVVC) and episodic vulvovaginal candidiasis (EVVC) had high MIC values. Conclusions: E-test is a reliable method for the susceptibility testing of Candida spp. due to its simplicity, reproducibility, and lack of specialized equipment. Resistant strains and non-albicans species were verified more in cases of EVVC than in PVVC. Clinical and mycological cure of patients with episodic vulvovaginal candidiasis or complicated cases occurred after prolonged treatment and sometimes with multiple antifungals use. 展开更多
关键词 Antifungal Susceptibility Candida Candidiasis Vulvovaginal E-TEST Non-Albicans Species
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Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents 被引量:1
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作者 Giovanni Damiani Chiara Franchi +6 位作者 Paolo Pigatto Andrea Altomare Alessia Pacifico Stephen Petrou Sebastiano Leone Maria Caterina Pace Marco Fiore 《World Journal of Hepatology》 CAS 2018年第2期329-336,共8页
AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α p... AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) therapy.METHODS This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV therapy.RESULTS Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological treatment.CONCLUSION DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy. 展开更多
关键词 Hepatitis C virus NEW Direct-Acting ANTIVIRAL agents PSORIASIS Biological disease MODIFYING drugs
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Cosmetic Lifting Effect of a Formula Combining Tetrahydroxypropyl Ethylenediamine, Ononis Spinosa and Glycerin as Shown by a New 2-D Imaging Method
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作者 Romain Roure Marion Lanctin +3 位作者 Alex Nkengne Virginie Nollent Liliane Dayan Christiane Bertin 《Journal of Cosmetics, Dermatological Sciences and Applications》 2013年第3期209-215,共7页
Facial sagging is a major aging change that affects the overall shape of the face. Sagging can negatively impact self-perception and consequently quality of life. In order to fight against this aging sign, we develope... Facial sagging is a major aging change that affects the overall shape of the face. Sagging can negatively impact self-perception and consequently quality of life. In order to fight against this aging sign, we developed a combination of three active ingredients: Tetrahydroxypropyl Ethylenediamine (THPE), Ononis Spinosa extract and Glycerin. In a clinical study, we assessed the efficacy of this association on facial sagging and wrinkles, with a special focus on immediate and lasting effects. Thirty-nine women applied the tested product daily during an eight-week treatment period. Clinical grading by experts and a new, easy to operate, 2-D imaging method were performed at different time points. The 2-D imaging method measured the upper eyelid lifting effect. The results showed an immediate and significant improvement in sagging and wrinkle parameters;these benefits were still observed seven hours after the first application. Results also showed a significant long-term improvement. The lifting effect calculated from the 2-D pictures was 1.08 mm immediately after application;the same method showed a 1.80 mm lifting effect following the eight-week treatment period. These results suggest that a skin care product combining THPE, Ononis Spinosa and Glycerin properties may be used to reduce sagging as well as wrinkles with both immediate and long term benefits. 展开更多
关键词 Facial SAGGING WRINKLES Tetrahydroxypropyl ETHYLENEDIAMINE Immediate EFFECT Long-Lasting EFFECT 2-D Imaging Lift Measurement
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Limphocutaneous Sporotrichosis Due to Sporothrix schenckii var schenckii: A Relapsing Case after Treatment with Potassium Iodide in Elderly
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作者 Eder R. Juárez-Durán Sabrina Escandón-Pérez +4 位作者 Fritz Cajuste-Sequeira Luis M. Sánchez-Navarro Carlos A. Barrera-Ochoa Rigoberto Hernández-Castro Roberto Arenas 《Advances in Microbiology》 2022年第4期192-197,共6页
Sporotrichosis is a subcutaneous mycosis caused by the Sporothrix schenckii complex. It has three classic clinical variants: fixed, lymphangitic, and systemic. Treatment in most cases has been itraconazole or potassiu... Sporotrichosis is a subcutaneous mycosis caused by the Sporothrix schenckii complex. It has three classic clinical variants: fixed, lymphangitic, and systemic. Treatment in most cases has been itraconazole or potassium iodide. The aim of this paper is to communicate an unusual relapsing case treated with IK. We report a 73-year-old woman with lymphangitic sporotrichosis, adequate response to treatment with potassium iodide, and recurrence 15 months after. A molecular test was performed through the amplification of a 331 bp fragment of the calmodulin gene. In both infections, the same specie was isolated. The effects of potassium iodide are briefly discussed, and we conclude that the same treatment can be prescribed, if no side effects are observed. 展开更多
关键词 SPOROTRICHOSIS Lymphangitic Sporotrichosis Sporothrix schenckii RECURRENCE Potassium Iodide
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<i>In Vitro</i>Effects of Photodynamic Therapy with Three Photosensitizers on <i>Candida</i>spp from Complicated Vulvovaginitis and Asymptomatic Women
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作者 Humberto Fabio Boatto Maria Sayonara de Moraes +7 位作者 Alexandre Paulo Machado Manoel Joã o Batista Castelo Girã o Gilglécia Novaes Pereira Santana Fernanda Aparecida Vieira Fernandes Orion Sant’anna Motter Borba Olga Fischman Gompertz 《Open Journal of Medical Microbiology》 2021年第4期283-297,共15页
<b><span style="font-family:Verdana;">Aim</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:;" "... <b><span style="font-family:Verdana;">Aim</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:;" "=""><span style="font-family:Verdana;"> To evaluate photodynamic therapy (PDT) </span><i><span style="font-family:Verdana;">in vitro</span></i><span style="font-family:Verdana;"> to reduce the growth of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp, and its synergy with the antifungals fluconazole and ketoconazole for inhibition of resistant, DDS and susceptible isolates from asymptomatic carriers and with complicated vulvovaginitis. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> Between 2017 and 2020</span></span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> we evaluated 230 women with vulvovaginal candidiasis and 400 asymptomatic. We obtained 130 positive cultures for </span><i><span style="font-family:Verdana;">Candida </span></i><span style="font-family:Verdana;">spp from vulvovaginitis and 94 asymptomatic. Yeasts were characterized by classical and molecular tests. Sensitivity to fluconazole and ketoconazole was evaluated by E-test. We used photodynamic light through blue LED, wavelengths between 450 to 470 nm, power of 260 mW, energy</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">f</span><span style="font-family:Verdana;">l</span><span style="font-family:;" "=""><span style="font-family:Verdana;">uence of 270 J/cm</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, for 15 minutes over all colonies of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp</span></span><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">Methylene blue (MB) at 450 mg/mL, 2% gentian violet (VG) and 50</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">μM curcumin (CR) were used in association or not with LED irradiation. Suspensions of </span><i><span style="font-family:Verdana;">Candida </span></i><span style="font-family:Verdana;">spp of 10</span><sup><span style="font-family:Verdana;">6</span></sup><span style="font-family:Verdana;"> CFU/mL, subjected to the different assays, were introduced in 96-well microplates, incubated for 48 hours at 35</span></span><span style="font-family:Verdana;"><span style="white-space:nowrap;">&#730;</span>C and the readings at 530</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">nm. The samples were finally cultivated in Petri plates containing Sabouraud dextrose agar to assess the growth inhibition. All procedures were in triplicate. </span><b><span style="font-family:Verdana;">Results:</span></b> <i><span style="font-family:Verdana;">C. albicans</span></i><span style="font-family:Verdana;"> was prevalent in vulvovaginal candidiasis, however, we also isolated non-</span><i><span style="font-family:Verdana;">albicans</span></i><span style="font-family:Verdana;"> species such as </span><i><span style="font-family:Verdana;">C. glabrata</span></i><span style="font-family:Verdana;">,</span><i><span style="font-family:Verdana;"> C. tropicalis</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">C. parapsilosis</span></i><span style="font-family:Verdana;">. There was a substantial reduction (66.6% to 83.8%) of the CFU/mL of the isolates treated with FDT. Gentian violet at 2% alone reduced the growth of CFU/ml of </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> spp from 69% to 75%. Among isolates of vaginitis and asymptomatic carriers, after using FDT, we found a reduction in resistant phenotypes and DDS for fluconazole in percentages from 20% to 100% for </span><i><span style="font-family:Verdana;">C. albicans</span></i><span style="font-family:Verdana;">, from 50% to 100% </span><i><span style="font-family:Verdana;">C. glabrata</span></i><span style="font-family:Verdana;">, 33.3% to 100% </span><i><span style="font-family:Verdana;">C. parapsilosis</span></i><span style="font-family:Verdana;"> and 100% </span><i><span style="font-family:Verdana;">C. tropicalis</span></i><span style="font-family:Verdana;">. For ketoconazole in the same isolates, there was a reduction in phenotypes with MIC</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">16 μg/mL of up to 50% in </span><i><span style="font-family:Verdana;">C. albicans</span></i><span style="font-family:Verdana;">, 50% to 100% </span><i><span style="font-family:Verdana;">C. glabrata</span></i><span style="font-family:Verdana;">, 50% to 100% </span><i><span style="font-family:Verdana;">C. tropicalis</span></i><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> PDT with MB, GV and CR revealed efficacy </span><i><span style="font-family:Verdana;">in vitro </span></i><span style="font-family:Verdana;">in reducing the growth of </span><i><span style="font-family:Verdana;">C. albicans</span></i><span style="font-family:Verdana;"> and non-</span><i><span style="font-family:Verdana;">albicans</span></i><span style="font-family:Verdana;">, especially due to chronic recurrent vulvovaginitis.</span></span> 展开更多
关键词 Photodynamic Therapy PHOTOSENSITIZERS Candida albicans Species Non-Albicans Complicated Fungal Vulvovaginitis
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Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis
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作者 Giovanni Damiani Sebastiano Leone +11 位作者 Kristen Fajgenbaum Nicola L Bragazzi Alessia Pacifico Rosalynn RZ Conic Paolo DM Pigatto Carlo Maiorana Pierpaolo Poli Emilio Berti Maria C Pace Piergiorgio Malagoli Vincenzo Bettoli Marco Fiore 《World Journal of Hepatology》 CAS 2019年第4期391-401,共11页
BACKGROUND Nonalcoholic fatty liver disease(NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver(NAFL) and non-alcoholic steatohepatitis(NASH). Furthermo... BACKGROUND Nonalcoholic fatty liver disease(NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver(NAFL) and non-alcoholic steatohepatitis(NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease(ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern.Hidradenitis suppurativa(HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed.AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients.METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH.RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients(P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index(ADDI) was significantly higher among patients with HS/NASH(5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only(2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups.CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores. 展开更多
关键词 Non-alcoholic steatohepatitis Non-alcoholic FATTY LIVER Nonalcoholic FATTY LIVER DISEASE End stage LIVER DISEASE HIDRADENITIS suppurativa
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A型肉毒毒素皮内注射治疗玫瑰痤疮持久性红斑及潮红专家共识 被引量:2
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作者 中华医学会皮肤性病学分会玫瑰痤疮研究中心 中国医师协会皮肤科医师分会玫瑰痤疮专业组 +3 位作者 黄莹雪 汪犇 李吉 宋为民 《中华皮肤科杂志》 CAS CSCD 北大核心 2023年第1期16-21,共6页
A型肉毒毒素是一种神经毒素,广泛用于皮肤美容。有证据表明,皮内注射A型肉毒毒素能改善玫瑰痤疮患者面部皮肤潮红及持续性红斑,但对治疗浓度、剂量、操作方法、疗程、治疗间隔等均存在差异。中华医学会皮肤性病学分会玫瑰痤疮研究中心... A型肉毒毒素是一种神经毒素,广泛用于皮肤美容。有证据表明,皮内注射A型肉毒毒素能改善玫瑰痤疮患者面部皮肤潮红及持续性红斑,但对治疗浓度、剂量、操作方法、疗程、治疗间隔等均存在差异。中华医学会皮肤性病学分会玫瑰痤疮研究中心、中国医师协会皮肤科分会玫瑰痤疮专业组在玫瑰痤疮诊疗指南的基础上,参考新近文献并结合诸多专家临床应用经验撰写本共识,为A型肉毒毒素皮内注射治疗玫瑰痤疮提供更科学、规范的参考依据。 展开更多
关键词 肉毒杆菌毒素类 A型 红斑痤疮 红斑 潮红 治疗 共识
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吗替麦考酚酯治疗免疫相关性皮肤病专家建议 被引量:6
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作者 邓丹琪 +7 位作者 左亚刚 郭竹秀 廖理超 刘毅 吕新翔 王鹏 赵梓纲 甄莉 《中华皮肤科杂志》 CAS CSCD 北大核心 2020年第11期869-874,共6页
吗替麦考酚酯可选择性抑制T、B淋巴细胞的增殖和活性,已广泛应用于多种免疫相关性皮肤病的治疗。在检索国内外文献的基础上,中国不同地域多位专家讨论和撰写了本建议。根据英国牛津大学循证医学中心制定的推荐等级标准,吗替麦考酚酯在... 吗替麦考酚酯可选择性抑制T、B淋巴细胞的增殖和活性,已广泛应用于多种免疫相关性皮肤病的治疗。在检索国内外文献的基础上,中国不同地域多位专家讨论和撰写了本建议。根据英国牛津大学循证医学中心制定的推荐等级标准,吗替麦考酚酯在成人中重度寻常型斑块状银屑病、成人大疱性类天疱疮和寻常型天疱疮的治疗中属于A级推荐;在成人系统性硬化症、成人中重度湿疹和中重度特应性皮炎的治疗中均属于B级推荐;在皮肤型红斑狼疮、皮肌炎、无肌病性皮肌炎、儿童系统性硬化症、儿童大疱性类天疱疮和儿童天疱疮、儿童中重度湿疹和特应性皮炎的治疗中属于C级推荐。 展开更多
关键词 自身免疫疾病 银屑病 类天疱疮 大疱性 天疱疮 硬皮病 系统性 皮炎 皮肌炎 吗替麦考酚酯
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防控冠状病毒感染疾病-19医护人员皮肤黏膜屏障防护共识 被引量:12
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作者 李恒进 +32 位作者 李航 陈辉 陈柳青 程波 刁萍 董励耘 高兴华 顾恒 何黎 纪超 晋红中 赖维 雷铁池 李利 李六亿 李若瑜 刘冬先 刘玮 陆前进 史赢 宋继权 陶娟 王宝玺 王刚 吴艳 项蕾红 谢君 徐金华 闫钇岑 姚志荣 张福仁 张建中 仲少敏 《中华皮肤科杂志》 CAS CSCD 北大核心 2020年第3期159-164,共6页
医护人员在防控冠状病毒感染疾病-19过程中极易发生皮肤黏膜屏障损伤,进而引起急、慢性皮炎和继发感染,还会加重原有皮肤疾病。本文围绕手部清洁、手套佩戴和使用口罩与护目镜所产生的问题,以及针对消毒紫外线、眼、耳、鼻、口腔、头发... 医护人员在防控冠状病毒感染疾病-19过程中极易发生皮肤黏膜屏障损伤,进而引起急、慢性皮炎和继发感染,还会加重原有皮肤疾病。本文围绕手部清洁、手套佩戴和使用口罩与护目镜所产生的问题,以及针对消毒紫外线、眼、耳、鼻、口腔、头发的皮肤黏膜屏障防护,介绍了具体防护措施及建议。为了保护皮肤黏膜屏障,应严格遵守穿戴防护设备及消毒清洁的规范,防护不足与过度都会对皮肤黏膜屏障产生不良影响;同时建议积极采用保湿等保护皮肤措施。 展开更多
关键词 2019新型冠状病毒 冠状病毒感染疾病-19 皮肤黏膜屏障 防护
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β受体阻滞剂治疗婴儿血管瘤中国专家共识 被引量:24
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作者 马琳 +3 位作者 王华 李丽 汤建萍 李萍 《中华皮肤科杂志》 CAS CSCD 北大核心 2020年第7期493-500,共8页
β受体阻滞剂是目前治疗婴儿血管瘤的一线药物,主要包括口服普萘洛尔和外用噻吗洛尔/卡替洛尔滴眼液。β受体阻滞剂药物选择及给药方式主要根据患儿年龄、瘤体部位、分型、分类及大小等因素综合决定。本共识对口服普萘洛尔的适应证及禁... β受体阻滞剂是目前治疗婴儿血管瘤的一线药物,主要包括口服普萘洛尔和外用噻吗洛尔/卡替洛尔滴眼液。β受体阻滞剂药物选择及给药方式主要根据患儿年龄、瘤体部位、分型、分类及大小等因素综合决定。本共识对口服普萘洛尔的适应证及禁忌证、治疗起始时间及剂量、疗程与停药指征、用药期间注意事项和不良反应的监测及处理和特殊人群治疗剂量、疗程以及外用β受体阻滞剂适应证、应用具体方法等进行总结,希望为皮肤科及相关专业医生规范应用β受体阻滞剂治疗婴儿血管瘤提供参考依据。 展开更多
关键词 血管瘤 婴儿 肾上腺素能Β受体拮抗剂 普萘洛尔 噻吗洛尔 卡替洛尔 专家共识
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斑贴试验临床应用专家共识(2020修订版) 被引量:20
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作者 郝飞 +2 位作者 李邻峰 顾恒 邹颖 《中华皮肤科杂志》 CAS CSCD 北大核心 2020年第4期239-243,共5页
变应性接触性皮炎是临床常见的过敏性疾病,斑贴试验是寻找并明确接触性变应原的金标准。随着接触性皮炎流行病学、发病机制和临床表现认识的加深,以及斑贴试验规范化应用要求的提高,有关共识需要不断更新和完善。本共识是在2015年版斑... 变应性接触性皮炎是临床常见的过敏性疾病,斑贴试验是寻找并明确接触性变应原的金标准。随着接触性皮炎流行病学、发病机制和临床表现认识的加深,以及斑贴试验规范化应用要求的提高,有关共识需要不断更新和完善。本共识是在2015年版斑贴试验临床应用专家共识的基础上进行更新,尤其细化了临床适应证的选择,完善了结果判断和解释,增加了延迟检测及患者教育等,以进一步规范斑贴试验的临床应用并提升其价值。 展开更多
关键词 斑片试验 皮炎 变应性接触性 变应原 专家共识
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中国皮肤恶性黑素瘤皮肤镜特征专家共识 被引量:8
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作者 刘洁 +3 位作者 邹先彪 辛琳琳 孟如松 朱晨雨 《中华皮肤科杂志》 CAS CSCD 北大核心 2020年第6期401-408,共8页
皮肤恶性黑素瘤(MM)是来源于黑素细胞的恶性肿瘤,恶性程度高,进展快,预后差,早期发现可极大提高生存率。皮肤镜作为一种无创检查手段,可提高早期诊断准确率,减少漏诊和误诊,避免盲目活检。本共识总结了不同类型MM的皮肤镜主要表现,并简... 皮肤恶性黑素瘤(MM)是来源于黑素细胞的恶性肿瘤,恶性程度高,进展快,预后差,早期发现可极大提高生存率。皮肤镜作为一种无创检查手段,可提高早期诊断准确率,减少漏诊和误诊,避免盲目活检。本共识总结了不同类型MM的皮肤镜主要表现,并简要概述需要鉴别诊断的疾病,旨在为MM的早期无创诊断提供依据。 展开更多
关键词 黑色素瘤 皮肤镜检查 专家共识
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日光性雀斑样痣、脂溢性角化病及扁平苔藓样角化病皮肤镜特征专家共识 被引量:14
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作者 刘洁 +1 位作者 舒畅 邹先彪 《中华皮肤科杂志》 CAS CSCD 北大核心 2019年第12期878-883,共6页
日光性雀斑样痣、脂溢性角化病及扁平苔藓样角化病是常见的良性表皮增生性疾病,其皮肤镜特征对于明确诊断、与其他皮肤肿瘤相鉴别、避免不必要的活检和手术以及动态监测皮损变化等都有一定帮助。本共识对这3种疾病的皮肤镜特征进行了总... 日光性雀斑样痣、脂溢性角化病及扁平苔藓样角化病是常见的良性表皮增生性疾病,其皮肤镜特征对于明确诊断、与其他皮肤肿瘤相鉴别、避免不必要的活检和手术以及动态监测皮损变化等都有一定帮助。本共识对这3种疾病的皮肤镜特征进行了总结。日光性雀斑样痣的皮肤镜特征主要为皮损边界清晰、虫蚀状边缘、模糊的色素网、指纹模式、棕色均质模式、假性网络。脂溢性角化病的皮肤镜特征主要为皮损边界清晰、粟粒样囊肿、粉刺样开口、脑回状模式、发夹样血管、摇晃试验中皮损整体移动。扁平苔藓样角化病的皮肤镜特征主要为胡椒粉样或颗粒模式以及周围可见日光性雀斑样痣、脂溢性角化病或光线性角化病的皮肤镜特征。 展开更多
关键词 皮肤镜检查 角化病 脂溢性 雀斑样痣 诊断 指南 扁平苔藓样角化病
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梅毒、淋病和生殖道沙眼衣原体感染诊疗指南(2020年) 被引量:208
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作者 王千秋 +3 位作者 刘全忠 徐金华 周平玉 苏晓红 《中华皮肤科杂志》 CAS CSCD 北大核心 2020年第3期168-179,共12页
梅毒、淋病和生殖道沙眼衣原体感染是我国目前重点防治的性传播疾病。梅毒的临床表现复杂,按照其发病时间、临床表现及传染方式,可分为一期梅毒、二期梅毒、三期梅毒、神经梅毒、隐性梅毒及先天梅毒等。淋病和生殖道沙眼衣原体感染主要... 梅毒、淋病和生殖道沙眼衣原体感染是我国目前重点防治的性传播疾病。梅毒的临床表现复杂,按照其发病时间、临床表现及传染方式,可分为一期梅毒、二期梅毒、三期梅毒、神经梅毒、隐性梅毒及先天梅毒等。淋病和生殖道沙眼衣原体感染主要侵犯泌尿生殖道,其临床表现从无症状到伴发各种并发症,差别较大。这3种性病的诊断应依据流行病学史、临床表现及实验室检查结果综合判断后确定。应尽早、规范并按推荐方案进行治疗。治疗后应进行必要的随访。淋病的病原体耐药已经成为临床关注的问题。 展开更多
关键词 梅毒 淋病 衣原体感染 沙眼衣原体 诊断 治疗 指南
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中国银屑病生物治疗专家共识(2019) 被引量:73
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作者 王刚 张学军 《中华皮肤科杂志》 CAS CSCD 北大核心 2019年第12期863-871,共9页
生物制剂在银屑病治疗中的应用越来越广泛,在解决重症、难治以及特殊类型银屑病方面发挥了积极的作用。如何合理、有效、安全地使用生物制剂已经成为临床工作中备受关注的问题。为此,我国银屑病诊疗领域部分专家依据国内外研究数据和临... 生物制剂在银屑病治疗中的应用越来越广泛,在解决重症、难治以及特殊类型银屑病方面发挥了积极的作用。如何合理、有效、安全地使用生物制剂已经成为临床工作中备受关注的问题。为此,我国银屑病诊疗领域部分专家依据国内外研究数据和临床经验,结合中国银屑病患者的特点,在深入讨论的基础上制订本共识,从主要生物制剂的应用原则与方法、疗效与安全性特点、患者的筛查与监测、常见问题与对策以及特殊人群应用的注意事项等方面,为临床医生提供了具体的指导意见。 展开更多
关键词 银屑病 治疗 生物制剂 专家共识
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儿童特应性皮炎相关食物过敏诊断与管理专家共识 被引量:21
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作者 王华 马琳 《中华皮肤科杂志》 CAS CSCD 北大核心 2019年第10期711-716,共6页
临床中,特应性皮炎(AD)相关食物过敏的诊断存在不规范及过度诊断的问题,而由此导致的不必要饮食回避对儿童健康具有潜在影响。与IgE介导的经典食物过敏不同,AD相关食物过敏可表现为非湿疹样表现、独立的湿疹样表现及混合型表现。AD患儿... 临床中,特应性皮炎(AD)相关食物过敏的诊断存在不规范及过度诊断的问题,而由此导致的不必要饮食回避对儿童健康具有潜在影响。与IgE介导的经典食物过敏不同,AD相关食物过敏可表现为非湿疹样表现、独立的湿疹样表现及混合型表现。AD患儿食物过敏的诊断需结合病史(包括详细过敏史和喂养史)、临床表现及相关辅助检查包括皮肤点刺试验、血清特异性IgE检测、特应性斑贴试验及口服食物激发试验。对合并食物过敏的AD患儿需要综合管理,饮食回避是治疗的主要手段,但需对营养状况、生长发育等进行定期监测,皮肤科医师、营养师、儿科医师等多学科合作。 展开更多
关键词 皮炎 特应性 食物过敏 诊断 儿童 免疫球蛋白E 口服食物激发试验
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