PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium.To our knowledge,this is the first report of this finding after intraocular antivascular endothelial g...PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium.To our knowledge,this is the first report of this finding after intraocular antivascular endothelial growth factor therapy.DESIGN:Observational case reports.METHODS:Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular degeneration.Both patients were treated with an intravitreal injection of pegaptanib sodium.RESULTS:One patient developed a retinal pigment epithelium tear one week after the intravitreal injection.The second patient developed a retinal pigment epithelium tear eight weeks after treatment.CONCLUSIONS:Although these cases may represent natural history,there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib sodium.Further studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.展开更多
文摘PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium.To our knowledge,this is the first report of this finding after intraocular antivascular endothelial growth factor therapy.DESIGN:Observational case reports.METHODS:Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular degeneration.Both patients were treated with an intravitreal injection of pegaptanib sodium.RESULTS:One patient developed a retinal pigment epithelium tear one week after the intravitreal injection.The second patient developed a retinal pigment epithelium tear eight weeks after treatment.CONCLUSIONS:Although these cases may represent natural history,there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib sodium.Further studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.
