Schwann cells are glial cells in the peripheral nervous system that provide trophic support for the growth and maintenance of sensory,motor,and autonomic neurons and ensheath their axons in either a myelinating or an ...Schwann cells are glial cells in the peripheral nervous system that provide trophic support for the growth and maintenance of sensory,motor,and autonomic neurons and ensheath their axons in either a myelinating or an unmyelinating form.Myelinating Schwann cells wrap around largedia meter axons to form m ultilayered myelin structures essential for the rapid action potential propagation from one node of Ranvier to the next node(saltatory conduction).展开更多
Glucagon-like peptide 1（GLP-1）is secreted from enteroendocrine L cells in response to nutrient ingestion and exhibits insulinotropic properties by stimulating specific G protein-linked receptors（GLP-1Rs）on pancrea...Glucagon-like peptide 1（GLP-1）is secreted from enteroendocrine L cells in response to nutrient ingestion and exhibits insulinotropic properties by stimulating specific G protein-linked receptors（GLP-1Rs）on pancreaticβcells.Several GLP-1 mimetics,such as exenatide（exendin-4（Ex-4））,liraglutide,and lixisenatide,have been developed and approved as treatments for patients with type 2 diabetes.These peptides show bioactiv-ities almost identical to those of GLP- 1 and have a substantially longer plasma half-life than GLP-1 because of their resistance to dipeptidyl peptidase-4, a GLP-1 degrading enzyme.展开更多
Diabetic peripheral neuropathy（DPN）is one of the most common and intractable complications of diabetes mellitus.Its irritating symptoms,such as paresthesia,hyperalgesia and allodynia,can be causes of insomnia and de...Diabetic peripheral neuropathy（DPN）is one of the most common and intractable complications of diabetes mellitus.Its irritating symptoms,such as paresthesia,hyperalgesia and allodynia,can be causes of insomnia and depression;whereas its progression to more advanced stages can result in serious consequences,such as lower limb amputations and lethal arrhythmias.展开更多
文摘Schwann cells are glial cells in the peripheral nervous system that provide trophic support for the growth and maintenance of sensory,motor,and autonomic neurons and ensheath their axons in either a myelinating or an unmyelinating form.Myelinating Schwann cells wrap around largedia meter axons to form m ultilayered myelin structures essential for the rapid action potential propagation from one node of Ranvier to the next node(saltatory conduction).
基金supported by a Grant-in-aid for Scientific Research from the Ministry of EducationScience+3 种基金Sports and Culture of Japan(grant number:25430056)the fund from Nukada Institute for Medical and Biological ResearchChibaJapan
文摘Glucagon-like peptide 1（GLP-1）is secreted from enteroendocrine L cells in response to nutrient ingestion and exhibits insulinotropic properties by stimulating specific G protein-linked receptors（GLP-1Rs）on pancreaticβcells.Several GLP-1 mimetics,such as exenatide（exendin-4（Ex-4））,liraglutide,and lixisenatide,have been developed and approved as treatments for patients with type 2 diabetes.These peptides show bioactiv-ities almost identical to those of GLP- 1 and have a substantially longer plasma half-life than GLP-1 because of their resistance to dipeptidyl peptidase-4, a GLP-1 degrading enzyme.
基金supported by a Grant-in-aid for Scientific Research from the Ministry of Education,Science,Sports and Culture of Japan(grant number:25430056)
文摘Diabetic peripheral neuropathy（DPN）is one of the most common and intractable complications of diabetes mellitus.Its irritating symptoms,such as paresthesia,hyperalgesia and allodynia,can be causes of insomnia and depression;whereas its progression to more advanced stages can result in serious consequences,such as lower limb amputations and lethal arrhythmias.
