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Efficient combination immunotherapy for liver cancer using harmonized activation of innate and adaptive immunity
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作者 Liang Wen Gaowei Wang +5 位作者 Chia-Hao Lin Panyisha Wu Chuanhui Peng Jin Lee Lifan Lu Gensheng Feng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2018年第S01期18-18,共1页
Objective:Immunotherapy that blocks inhibitory pathways in T lymphocytes,such as the PD-L1/PD-1 axis,is undergoing evaluation for various solid tumors.Notably,this emerging therapeutic approach is already in clinical ... Objective:Immunotherapy that blocks inhibitory pathways in T lymphocytes,such as the PD-L1/PD-1 axis,is undergoing evaluation for various solid tumors.Notably,this emerging therapeutic approach is already in clinical trials for advanced hepatocellular carcinoma(HCC). 展开更多
关键词 EFFICIENT COMBINATION IMMUNOTHERAPY
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Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatorystress
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作者 Jean Y. J. WANG 《Cell Research》 SCIE CAS CSCD 2005年第1期43-48,共6页
Genotoxic agents or inflammatory cytokines activate cellular stress responses and trigger programmed cell death. We have identified a signal transduction module, including three nuclear proteins that participate in th... Genotoxic agents or inflammatory cytokines activate cellular stress responses and trigger programmed cell death. We have identified a signal transduction module, including three nuclear proteins that participate in the regulation of cell death induced by chemotherapeutic agents and tumor necrosis factor (TNF). In this nuclear signaling module, retino- blastoma protein (Rb) functions as an inhibitor of apoptotic signal transduction. Inactivation of Rb by phosphorylation or caspase-dependent cleavage/degradation is required for cell death to occur. Rb inhibits the Abl tyrosine kinase. Thus, Rb inactivation is a pre-requisite for Abl activation by DNA damage or TNF. Activation of nuclear Abl and its down- stream effector p73 induces mitochondriadependent cell death. The involvement of these nuclear signal transducers in TNF induced apoptosis, which does not require new gene expression, indicates that nuclear events other than transcrip- tion can contribute to extrinsic apoptotic signal transduction. 展开更多
关键词 apoptosis DNA damage MITOCHONDRIA TNF Rb ABL P73 p53.
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