The international community has made significant efforts to flatten the COVID-19 curve,including predicting transmission[1,2],executing unprecedented global lockdowns and social distancing[3,4],promoting the wearing o...The international community has made significant efforts to flatten the COVID-19 curve,including predicting transmission[1,2],executing unprecedented global lockdowns and social distancing[3,4],promoting the wearing of facemasks and social distancing measures[5],and isolating confirmed cases and contacts[6].Because of the adverse consequences of these lockdown measures[7],many cities have reopened so they can rebuild their economies.However,as mobility has gradually returned towards normal,imported cases from unknown sources have disrupted the recovery situation,and cities are continually at high risk of new waves of infection[8,9]since airborne transmission is the dominant transmission route[10].展开更多
In a recent study published in Nature Immunology,Zheng et al.discovered that intratumoral NK cells were smooth and rounded as opposed to the typical vili-rich,rougher surface of normal NK cells.1 This phenotype was li...In a recent study published in Nature Immunology,Zheng et al.discovered that intratumoral NK cells were smooth and rounded as opposed to the typical vili-rich,rougher surface of normal NK cells.1 This phenotype was linked to a specific deficit in membrane sphingomyelin lipids that impaired tumor cell killing.Importantly,results suggested that NK cell-mediated immunosurveillance of cancer can be rescued by blocking enzymes that degrade sphingomyelin,uncovering a potential novel‘metabolic immune checkpoint’for which pharmacological inhibition holds promise for cancer therapy.NK cells are generally considered a subset of innate lymphoid cells that mediate cellular cytotoxicity.展开更多
基金support from the National Research FoundationPrime Minister’s Office+7 种基金Singapore under its Campus for Research Excellence and Technological Enterprise(CREATE)programmeThe Hong Kong Polytechnic University Strategic Hiring Scheme(P0036221)support from the Key Program of National Natural Science Foundation of China(41930648)supports from the Hong Kong Research Grants Council(15602619,15603920,and C7064-18GF)supports from the Hong Kong Research Grants Council(14605920,14611621,and C4023-20GF)support from the National University of SingaporeMinistry of Education,Tier 1 under WBS R-109-000-270-133Ministry of Natural Resources of the People’s Republic of China(GS(2021)7327)。
文摘The international community has made significant efforts to flatten the COVID-19 curve,including predicting transmission[1,2],executing unprecedented global lockdowns and social distancing[3,4],promoting the wearing of facemasks and social distancing measures[5],and isolating confirmed cases and contacts[6].Because of the adverse consequences of these lockdown measures[7],many cities have reopened so they can rebuild their economies.However,as mobility has gradually returned towards normal,imported cases from unknown sources have disrupted the recovery situation,and cities are continually at high risk of new waves of infection[8,9]since airborne transmission is the dominant transmission route[10].
基金This work was supported by grants from the Swedish Cancer Foundation and Swedish Research Council(to M.C.and Y.T.B.)the Knut and Alice Wallenberg Fellows program(to Y.T.B.).
文摘In a recent study published in Nature Immunology,Zheng et al.discovered that intratumoral NK cells were smooth and rounded as opposed to the typical vili-rich,rougher surface of normal NK cells.1 This phenotype was linked to a specific deficit in membrane sphingomyelin lipids that impaired tumor cell killing.Importantly,results suggested that NK cell-mediated immunosurveillance of cancer can be rescued by blocking enzymes that degrade sphingomyelin,uncovering a potential novel‘metabolic immune checkpoint’for which pharmacological inhibition holds promise for cancer therapy.NK cells are generally considered a subset of innate lymphoid cells that mediate cellular cytotoxicity.
