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多囊卵巢综合征妇女血浆metastin水平与胰岛素抵抗及游离雄激素水平呈负相关 被引量:3
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作者 Panidis D. Rousso D. +2 位作者 Koliakos G. A. Kourtis 李跃萍 《世界核心医学期刊文摘(妇产科学分册)》 2006年第12期19-20,共2页
Objective:This study was designed to:1 measure,for the first time,metastin (kisspeptin) levels in women with polycystic ovary syndrome (PCOS),a condition associated with hypersecretion of LH and hyperandrogenemia; and... Objective:This study was designed to:1 measure,for the first time,metastin (kisspeptin) levels in women with polycystic ovary syndrome (PCOS),a condition associated with hypersecretion of LH and hyperandrogenemia; and 2 investigate the possible correlations between metastin and PCOS-related reproductive and metabolic disturbances. Design:Clinical study. Setting:University hospital. Patient(s):Twenty-eight obese and overweight (body mass index BMI > 25 kg/m2) women with PCOS,28 normal weight (BMI < 25 kg/m2) women with the syndrome,and 13 obese and overweight controls (ovulatory women without clinical or biochemical hyperandrogenemia)-were selected. Intervention(s):Blood samples were collected between day 3 and day 6 of a spontaneous bleeding episode in the PCOS groups and a menstrual cycle of the controls,at 9:00 AM,after an overnight fast. Main Outcome Measure(s):Circulating levels of LH,FSH,PRL,T,Δ4-androstenedione (A),DHEAS,17α-OH-P,sex hormone-binding globulin (SHBG),insulin,glucose,and metastin were measured. Result(s):Both normal weight women with PCOS and obese controls were less insulin resistant and had significantly higher metastin levels,compared to obese and overweight women with the syndrome. Plasma kisspeptin levels were negatively correlated with BMI,free androgen index,and indices of insulin resistance. Conclusion(s):These results indicate that metastin is negatively associated with free androgen levels. The PCOS-associated insulin resistance and consequent hyperinsulinemia probably contribute to this effect by 1 stimulating androgen synthesis by the polycystic ovary (PCO) and 2 suppressing SHBG production in the liver. 展开更多
关键词 多囊卵巢综合征 雄激素水平 METASTIN 胰岛素抵抗 负相关 雄激素分泌 黄体生成素 高胰岛素血
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异位妊娠时肌酸磷酸激酶作用再探:MB及MM同工酶比例的重要诊断价值 被引量:1
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作者 Katsikis I. Rousso D. +1 位作者 Farmakiotis D. 李奎 《世界核心医学期刊文摘(妇产科学分册)》 2006年第4期7-7,共1页
Objective: Although evidence on elevated creatine phosphokinase (CPK) as a tool for the diagnosis of ectopic pregnancy (EP) is rather conflictive, no previous study on CPK isoenzyme levels and their relative ratio was... Objective: Although evidence on elevated creatine phosphokinase (CPK) as a tool for the diagnosis of ectopic pregnancy (EP) is rather conflictive, no previous study on CPK isoenzyme levels and their relative ratio was found in the literature. Study design: Forty women with EP, 20 with intrauterine (IU) abortive gestation, and 20 regular pregnant women (controls) were studied. Serum total CPK, CPK-MB, and CPK-MM levels were measured at the time of presentation and 24 hours after surgery. Relative operating characteristic (ROC) curves were plotted. Results: Women with EP had significantly higher CPK concentrations and a significantly decreased CPK-MB relative ratio (CPK-MB%), compared with both women with IU abortive pregnancy and controls. The ROC curves demonstrated a significant discriminatory ability of both increased total CPK and decreased CPK-MB%ratio for the diagnosis of EP. Conclusion: Determination of CPK isoenzyme fractions can significantly enhance the diagnostic value of total maternal CPK in the prediction of ectopic pregnancy. 展开更多
关键词 异位妊娠 MB MM 肌酸磷酸激酶 内孕 宫内孕流产 流产妇女 对比值 操作特性 研究设计
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多囊卵巢综合征的胰岛素敏感指数、β-细胞功能及血清前胰岛素水平
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作者 Panidis D. Macut D. +1 位作者 Farmakiotis D. 朱晓明 《世界核心医学期刊文摘(妇产科学分册)》 2006年第10期23-24,共2页
Background: The study aim was to investigate the relationship between insulin resistance(IR), β-cell function(βF), hyperandrogenism and proinsulin levels during an oral glucose tolerance test(OGTT) in women with pol... Background: The study aim was to investigate the relationship between insulin resistance(IR), β-cell function(βF), hyperandrogenism and proinsulin levels during an oral glucose tolerance test(OGTT) in women with polycystic ovary syndrome(PCOS). Methods: One hundred and twenty-six selected women were classified as follows: PCOS, BMI >25 kg/m2(n=39); PCOS, BMI< 25 kg/m2(n=54); controls, BMI >25 kg/m2(n=14); controls, BMI< 25 kg/m2(n=19). Blood samples were collected between the third and sixth day of a spontaneous menstrual cycle, at 9:00 a.m., after an overnight fast. Serum levels of FSH, LH, PRL, 17α-OH-progesterone, SHBG, testosterone, Δ4-androstenedione, insulin, proinsulin and glucose were measured. A 75 g OGTT was performed, and concentrations of glucose, insulin and proinsulin were also measured at t=30, 60, 90, and 120 min. Results: The markers of insulin secretion and the AUC for proinsulin were higher in obese and overweight women and in women with PCOS, respectively. The AUC for proinsulin was positively correlated with markers of IR, βF and androgen levels. An inverse relationship between PI/I values and indices of IR and βF was observed. Conclusions: Increased proinsulin levels reflect, most probably, insulin resistance, which is the key disorder in PCOS-associated metabolic abnormalities. β-Cell function, pre-proinsulin mRNA processing and proinsulin conversion to insulin could be initially increased as a result of IR. An interaction between circulating proinsulin and androgen biosynthesis or action might also exist. 展开更多
关键词 多囊卵巢综合征 胰岛素敏感指数 胰岛素抵抗 黄体生成素 胰岛素浓度 胰岛素分泌 激素过多症 卵泡刺激
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