In the recent issue of Nature Immunology,Li et al.present a mechanistic insight into neutrophilic cell death and its role in systemic lupus erythematosus(SLE).1 Several groups reported an altered neutrophil function a...In the recent issue of Nature Immunology,Li et al.present a mechanistic insight into neutrophilic cell death and its role in systemic lupus erythematosus(SLE).1 Several groups reported an altered neutrophil function and enhanced neutrophilic cell death in SLE patients that provoke a sustained interferon(IFN)production.2 In a recent issue of Nature they report that enhanced ferroptosis in neutrophils results in a breakdown of immune tolerance in SLE.1 Ferroptosis has recently been identified as a novel type of regulated cell death that is driven by lipid peroxidation.Ferroptosis is implicated in a variety of pathological contexts such as cancer,(neuro-)degenerative diseases,but also in immune-mediated diseases such as non-alcoholic steatohepatitis(NASH),diabetes,multiple sclerosis(MS),and asthma.3 Nevertheless,cell-specific functions of ferroptosis remained less clear.Neutrophils are known to spontaneously undergo cell death,which is partially related to their high ROS production.展开更多
文摘In the recent issue of Nature Immunology,Li et al.present a mechanistic insight into neutrophilic cell death and its role in systemic lupus erythematosus(SLE).1 Several groups reported an altered neutrophil function and enhanced neutrophilic cell death in SLE patients that provoke a sustained interferon(IFN)production.2 In a recent issue of Nature they report that enhanced ferroptosis in neutrophils results in a breakdown of immune tolerance in SLE.1 Ferroptosis has recently been identified as a novel type of regulated cell death that is driven by lipid peroxidation.Ferroptosis is implicated in a variety of pathological contexts such as cancer,(neuro-)degenerative diseases,but also in immune-mediated diseases such as non-alcoholic steatohepatitis(NASH),diabetes,multiple sclerosis(MS),and asthma.3 Nevertheless,cell-specific functions of ferroptosis remained less clear.Neutrophils are known to spontaneously undergo cell death,which is partially related to their high ROS production.
