Generalized Linear Mixed Model (GLMM) has been widely used in small area estimation for health indicators. Bayesian estimation is usually used to construct statistical intervals, however, its computational intensity i...Generalized Linear Mixed Model (GLMM) has been widely used in small area estimation for health indicators. Bayesian estimation is usually used to construct statistical intervals, however, its computational intensity is a big challenge for large complex surveys. Frequentist approaches, such as bootstrapping, and Monte Carlo (MC) simulation, are also applied but not evaluated in terms of the interval magnitude, width, and the computational time consumed. The 2013 Florida Behavioral Risk Factor Surveillance System data was used as a case study. County-level estimated prevalence of three health-related outcomes was obtained through a GLMM;and their 95% confidence intervals (CIs) were generated from bootstrapping and MC simulation. The intervals were compared to 95% credential intervals through a hierarchial Bayesian model. The results showed that 95% CIs for county-level estimates of each outcome by using MC simulation were similar to the 95% credible intervals generated by Bayesian estimation and were the most computationally efficient. It could be a viable option for constructing statistical intervals for small area estimation in public health practice.展开更多
Recent studies have explored the relationship between aerosol optical depth (AOD) measurements by satellite sensors and concentrations of particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5). Howeve...Recent studies have explored the relationship between aerosol optical depth (AOD) measurements by satellite sensors and concentrations of particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5). However, relatively little is known about spatial and temporal patterns in this relationship across the contiguous United States. In this study, we investigated the relationship between US Environmental Protection Agency estimates of PM2.5 concentrations and Moderate Resolution Imaging Spectroradiometer (MODIS) AOD measurements provided by two NASA satellites (Terra and Aqua) across the contiguous United States during 2005. We found that the combined use of both satellite sensors provided more AOD coverage than the use of either satellite sensor alone, that the correlation between AOD measurements and PM2.5 concentrations varied substantially by geographic location, and that this correlation was stronger in the summer and fall than that in the winter and spring.展开更多
Objective:This study explores geographic,system,and organizational constructs that predict medical care teams’willingness to administer fluoride varnish and conduct oral health risk assessments.Methods:A cross-sectio...Objective:This study explores geographic,system,and organizational constructs that predict medical care teams’willingness to administer fluoride varnish and conduct oral health risk assessments.Methods:A cross-sectional survey of voluntary health professionals attending trainings on interprofessional oral health practice was completed at ten meetings across the United States from April through September,2016.Bivariate and multivariate analyses were used to examine un-known correlates of oral health prevention and intervention at geographic,organizational,and sys-tem levels relating to the impact of referral mechanisms and systems as well as health information technology on fluoride varnish administration and risk-based oral evaluations.Results:A convenience cohort(n=560)from 44 states was examined.Most(68.7%,n=385)agreed with the dependent variable“medical providers at our site,or part of our network,are admin-istering fluoride varnish and identifying oral health risk factors in the majority of patients seen.”In bivariate analysis,organization type(P=0.0067),having successful referral systems(P<0.0001),and electronic health record(EHR)utility(P<0.0001)were associated with the dependent vari-able.No geographic indicators were significant.All referral system indicators were significant in multivariate analysis.Dependable referrals(P<0.0001),EHR utility(P=0.0054),and type of re-ferral(P=0.0009)were predictors of the dependent variable.The odds of those reporting a depend-able referral system and dependent variable agreement were 4.5 times greater than for those who lacked dependable referral systems(odds ratio 4.54,confidence interval 2.79-7.39).The odds of those who had dependable EHRs and dependent variable agreement were 2.4 times greater than for those who lacked useful EHRs(odds ratio 2.4,confidence interval 1.29-4.37).Conclusion:The dependability of medical-to-dental referral systems and processes impacts the administration of fluoride varnish and identification of oral health risk factors by motivated primary care teams.Additionally,the ease of EHR use and the availability of electronic information exchange were found to impact primary care oral health practice.展开更多
Headache is one of the commonest complaints that doctors need to address in clinical settings.The genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reporte...Headache is one of the commonest complaints that doctors need to address in clinical settings.The genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reported headache and self-reported migraine were genetically correlated.In this study,we performed a meta-analysis of genome-wide association studies(GWAS)on the self-reported headache phenotype from the UK Biobank and the self-reported migraine phenotype from the 23andMe using the Unified Score-based Association Test(metaUSAT)software for genetically correlated phenotypes(N=397,385).We identified 38 loci for headaches,of which 34 loci have been reported before and four loci were newly suggested.The LDL receptor related protein 1(LRP1)-Signal Transducer and Activator of Transcription 6(STAT6)-Short chain Dehydrogenase/Reductase family 9C member 7(SDR9C7)region in chromosome 12 was the most significantly associated locus with a leading p value of 1.24×10^(-62)of rs11172113.The One Cut homeobox 2(ONECUT2)gene locus in chromosome 18 was the strongest signal among the four new loci with a p value of 1.29×10^(-9)of rs673939.Our study demonstrated that the genetically correlated phenotypes of self-reported headache and self-reported migraine can be meta-analysed together in theory and in practice to boost study power to identify more variants for headaches.This study has paved way for a large GWAS meta-analysis involving cohorts of different while genetically correlated headache phenotypes.展开更多
1介绍鉴于美国农业部（U.S.Department of Agriculture,USDA）所实施的一些联邦学校膳食项目（如全国学校午餐计划）,学生们每天摄取的热量达一半都是在学校里获得。2012年,USDA发布了针对学校膳食的新版营养标准a。这些标准是对学校膳...1介绍鉴于美国农业部（U.S.Department of Agriculture,USDA）所实施的一些联邦学校膳食项目（如全国学校午餐计划）,学生们每天摄取的热量达一半都是在学校里获得。2012年,USDA发布了针对学校膳食的新版营养标准a。这些标准是对学校膳食项目实施超过15年来的首次重大修订,反映了当前国家的膳食指南和医药协会的建议,以满足学生的营养需求。展开更多
文摘Generalized Linear Mixed Model (GLMM) has been widely used in small area estimation for health indicators. Bayesian estimation is usually used to construct statistical intervals, however, its computational intensity is a big challenge for large complex surveys. Frequentist approaches, such as bootstrapping, and Monte Carlo (MC) simulation, are also applied but not evaluated in terms of the interval magnitude, width, and the computational time consumed. The 2013 Florida Behavioral Risk Factor Surveillance System data was used as a case study. County-level estimated prevalence of three health-related outcomes was obtained through a GLMM;and their 95% confidence intervals (CIs) were generated from bootstrapping and MC simulation. The intervals were compared to 95% credential intervals through a hierarchial Bayesian model. The results showed that 95% CIs for county-level estimates of each outcome by using MC simulation were similar to the 95% credible intervals generated by Bayesian estimation and were the most computationally efficient. It could be a viable option for constructing statistical intervals for small area estimation in public health practice.
文摘Recent studies have explored the relationship between aerosol optical depth (AOD) measurements by satellite sensors and concentrations of particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5). However, relatively little is known about spatial and temporal patterns in this relationship across the contiguous United States. In this study, we investigated the relationship between US Environmental Protection Agency estimates of PM2.5 concentrations and Moderate Resolution Imaging Spectroradiometer (MODIS) AOD measurements provided by two NASA satellites (Terra and Aqua) across the contiguous United States during 2005. We found that the combined use of both satellite sensors provided more AOD coverage than the use of either satellite sensor alone, that the correlation between AOD measurements and PM2.5 concentrations varied substantially by geographic location, and that this correlation was stronger in the summer and fall than that in the winter and spring.
文摘Objective:This study explores geographic,system,and organizational constructs that predict medical care teams’willingness to administer fluoride varnish and conduct oral health risk assessments.Methods:A cross-sectional survey of voluntary health professionals attending trainings on interprofessional oral health practice was completed at ten meetings across the United States from April through September,2016.Bivariate and multivariate analyses were used to examine un-known correlates of oral health prevention and intervention at geographic,organizational,and sys-tem levels relating to the impact of referral mechanisms and systems as well as health information technology on fluoride varnish administration and risk-based oral evaluations.Results:A convenience cohort(n=560)from 44 states was examined.Most(68.7%,n=385)agreed with the dependent variable“medical providers at our site,or part of our network,are admin-istering fluoride varnish and identifying oral health risk factors in the majority of patients seen.”In bivariate analysis,organization type(P=0.0067),having successful referral systems(P<0.0001),and electronic health record(EHR)utility(P<0.0001)were associated with the dependent vari-able.No geographic indicators were significant.All referral system indicators were significant in multivariate analysis.Dependable referrals(P<0.0001),EHR utility(P=0.0054),and type of re-ferral(P=0.0009)were predictors of the dependent variable.The odds of those reporting a depend-able referral system and dependent variable agreement were 4.5 times greater than for those who lacked dependable referral systems(odds ratio 4.54,confidence interval 2.79-7.39).The odds of those who had dependable EHRs and dependent variable agreement were 2.4 times greater than for those who lacked useful EHRs(odds ratio 2.4,confidence interval 1.29-4.37).Conclusion:The dependability of medical-to-dental referral systems and processes impacts the administration of fluoride varnish and identification of oral health risk factors by motivated primary care teams.Additionally,the ease of EHR use and the availability of electronic information exchange were found to impact primary care oral health practice.
基金Funding This study was mainly funded by the Wellcome Trust Strategic Award“Stratifying Resilience and Depression Longitudinally”(STRADL)with Reference Number 104036/Z/14/Z.
文摘Headache is one of the commonest complaints that doctors need to address in clinical settings.The genetic mechanisms of different types of headache are not well understood while it has been suggested that self-reported headache and self-reported migraine were genetically correlated.In this study,we performed a meta-analysis of genome-wide association studies(GWAS)on the self-reported headache phenotype from the UK Biobank and the self-reported migraine phenotype from the 23andMe using the Unified Score-based Association Test(metaUSAT)software for genetically correlated phenotypes(N=397,385).We identified 38 loci for headaches,of which 34 loci have been reported before and four loci were newly suggested.The LDL receptor related protein 1(LRP1)-Signal Transducer and Activator of Transcription 6(STAT6)-Short chain Dehydrogenase/Reductase family 9C member 7(SDR9C7)region in chromosome 12 was the most significantly associated locus with a leading p value of 1.24×10^(-62)of rs11172113.The One Cut homeobox 2(ONECUT2)gene locus in chromosome 18 was the strongest signal among the four new loci with a p value of 1.29×10^(-9)of rs673939.Our study demonstrated that the genetically correlated phenotypes of self-reported headache and self-reported migraine can be meta-analysed together in theory and in practice to boost study power to identify more variants for headaches.This study has paved way for a large GWAS meta-analysis involving cohorts of different while genetically correlated headache phenotypes.
文摘1介绍鉴于美国农业部（U.S.Department of Agriculture,USDA）所实施的一些联邦学校膳食项目（如全国学校午餐计划）,学生们每天摄取的热量达一半都是在学校里获得。2012年,USDA发布了针对学校膳食的新版营养标准a。这些标准是对学校膳食项目实施超过15年来的首次重大修订,反映了当前国家的膳食指南和医药协会的建议,以满足学生的营养需求。
