This three-year study, based on the Guangzhou Institute of Respiratory Disease （GRID）, chronic obstructive pulmonary disease （COPD） Biobank, was conducted in 36 COPD patients to estimate whether changes in levels ...This three-year study, based on the Guangzhou Institute of Respiratory Disease （GRID）, chronic obstructive pulmonary disease （COPD） Biobank, was conducted in 36 COPD patients to estimate whether changes in levels of leukocytes, erythrocytes, hemoglobin, and platelets were related to changes in air pollutant concentration. Daily NO2 levels exhibited significant differences between baseline years and the 2010 Asian Game period. We observed significant reductions in leukocyte and neutrophils counts levels, by 15.51% and 23.01%, from pre-Asian Games to during-Asian Games, respectively. In the post-Asian Game period, most pollutants approximated pre-Asian Game period levels, and similar effects were demonstrated in leukocyte and neutrophil counts. For both items, we identified significant increases resulting from elevated NO2 at lag days 0-2/5-6. We concluded that reductions in pollutants during the intervention period were associated with inactivation of hematological events in COPD.展开更多
Autophagy is a lysosomal-mediated degradation pro-cess that controls the turnover of organelles and long-lived proteins.Outside of its role in maintaining cellu-lar homeostasis,autophagy is frequently stimulated in re...Autophagy is a lysosomal-mediated degradation pro-cess that controls the turnover of organelles and long-lived proteins.Outside of its role in maintaining cellu-lar homeostasis,autophagy is frequently stimulated in response to stress conditions such as those imposed by chemotherapy,nutrient deprivation,and microenviron-mental disruption.In this capacity,autophagy serves as a mechanism to generate alternative sources of metabolic fuel that promote survival when preferred energy gener-ating pathways are impaired[1].Over the past decade,stress-induced autophagy has emerged as an important driver of malignant progression and anticancer drug resistance.Virtually all classes of clinically relevant anti-cancer agents,as well as radiotherapy,have been dem-onstrated to stimulate autophagy in preclinical studies[2].In the overwhelming majority of cases,genetically or pharmacologically impairing autophagy has been shown to yield therapeutic benefit in a manner that significantly improves the efficacy of the relevant agents or modalities[3].展开更多
基金supported by grants from National Natural Science Foundation of China[81520108001,81700043]the 973 Key Scheme of China[2015CB553406]+2 种基金Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2014,W Lu)Guangzhou Department of Education for Innovative Team[13C08]Guangdong Natural Science Foundation[2016A030313593]
文摘This three-year study, based on the Guangzhou Institute of Respiratory Disease （GRID）, chronic obstructive pulmonary disease （COPD） Biobank, was conducted in 36 COPD patients to estimate whether changes in levels of leukocytes, erythrocytes, hemoglobin, and platelets were related to changes in air pollutant concentration. Daily NO2 levels exhibited significant differences between baseline years and the 2010 Asian Game period. We observed significant reductions in leukocyte and neutrophils counts levels, by 15.51% and 23.01%, from pre-Asian Games to during-Asian Games, respectively. In the post-Asian Game period, most pollutants approximated pre-Asian Game period levels, and similar effects were demonstrated in leukocyte and neutrophil counts. For both items, we identified significant increases resulting from elevated NO2 at lag days 0-2/5-6. We concluded that reductions in pollutants during the intervention period were associated with inactivation of hematological events in COPD.
文摘Autophagy is a lysosomal-mediated degradation pro-cess that controls the turnover of organelles and long-lived proteins.Outside of its role in maintaining cellu-lar homeostasis,autophagy is frequently stimulated in response to stress conditions such as those imposed by chemotherapy,nutrient deprivation,and microenviron-mental disruption.In this capacity,autophagy serves as a mechanism to generate alternative sources of metabolic fuel that promote survival when preferred energy gener-ating pathways are impaired[1].Over the past decade,stress-induced autophagy has emerged as an important driver of malignant progression and anticancer drug resistance.Virtually all classes of clinically relevant anti-cancer agents,as well as radiotherapy,have been dem-onstrated to stimulate autophagy in preclinical studies[2].In the overwhelming majority of cases,genetically or pharmacologically impairing autophagy has been shown to yield therapeutic benefit in a manner that significantly improves the efficacy of the relevant agents or modalities[3].
