Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components,good biocompatibility,and high targeting.However,their large relativ...Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components,good biocompatibility,and high targeting.However,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their usefulness.Nanotechnology can address these issues by improving the therapeutic value,bioavailability,permeability,and absorption of biomacromolecules while regulating their retention time in the body.Especially,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental contamination.In this review,we highlight a set of unique nanosizing strategies based on SCF technology for biomacromolecular nanomedicine,and extensively discuss their characteristics and mechanisms.In particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also considered.We further provide perspectives on the opportunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.展开更多
基金supported by the Major State Basic Research Development Program of China(Nos.2023YFB3810000 and 2018YFA0107301)the National Natural Science Foundation of China(NSFC)(Nos.U22A20333,81925019,U1705281,and 82202330)+4 种基金the Fundamental Research Funds for the Central Universities(Nos.20720190088 and 20720200019)the Science Foundation of Fujian Province(No.2020Y4003)the Program for New Century Excellent Talents in University,China(No.NCET-13-0502)Shenzhen Science and Technology Program(No.JCYJ20220530143213029)China Postdoctoral Science Foundation(No.2023T160383)。
文摘Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components,good biocompatibility,and high targeting.However,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their usefulness.Nanotechnology can address these issues by improving the therapeutic value,bioavailability,permeability,and absorption of biomacromolecules while regulating their retention time in the body.Especially,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental contamination.In this review,we highlight a set of unique nanosizing strategies based on SCF technology for biomacromolecular nanomedicine,and extensively discuss their characteristics and mechanisms.In particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also considered.We further provide perspectives on the opportunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.
