Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives: To estimate the sex-and age-s...Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives: To estimate the sex-and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample. Design: Population-based retrospective incidence case review. Setting: Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project. Participants: Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003. Main Outcome Measures: Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time. Results: During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the age adjusted incidence of basal cell carcinoma per 100 000 persons was 25.9 (95%confidence interval [CI], 22.6-29.2) for women and 20.9 (95%CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P<.001) but not men (P=.19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0%of tumors were solely nodular basal cell carcinoma and 11.0%had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age-and sex-adjusted incidence per 100 000 persons of 3.9 (95%/ CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P=.01) and men (P=.04). Conclusions: This populationbased study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.展开更多
In this study, we present a case of a patient who has not been occupationally exposed to reactive dyes, but did present with a dermatitis from wearing a dark cotton garment. The patient experienced reactivation of his...In this study, we present a case of a patient who has not been occupationally exposed to reactive dyes, but did present with a dermatitis from wearing a dark cotton garment. The patient experienced reactivation of his dermatitis when rewearing a new unwashed dark T- shirt made of 100% cotton (in fact, the patient reported that it had to be washed at least 3 times before the skin reaction disappeared). He presented positive patch tests to 6 reactive dyes from Chemotechnique textile series. The clothing could not be proved as the true cause of the dermatitis, but resolution occurred upon removal of the suspected garment. This suggests that contact allergy to the reactive dyes (he did not react to any other dyes and his garment was a natural fabric)was likely responsible. With this report,we would like to emphasize that reactive dyes, as a class, should be considered as potential allergens, both occupationally and from non- occupational exposure such as garments. If garments containing reactive dyes are not properly rinsed in the manufacturing process, we believe that excess of dye can be retained that may cause allergic contact dermatitis (ACD). As the reactive dyes and their hydrolysis products are very water- soluble, they can be easily washed off to prevent ACD.展开更多
文摘Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives: To estimate the sex-and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample. Design: Population-based retrospective incidence case review. Setting: Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project. Participants: Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003. Main Outcome Measures: Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time. Results: During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the age adjusted incidence of basal cell carcinoma per 100 000 persons was 25.9 (95%confidence interval [CI], 22.6-29.2) for women and 20.9 (95%CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P<.001) but not men (P=.19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0%of tumors were solely nodular basal cell carcinoma and 11.0%had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age-and sex-adjusted incidence per 100 000 persons of 3.9 (95%/ CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P=.01) and men (P=.04). Conclusions: This populationbased study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.
文摘In this study, we present a case of a patient who has not been occupationally exposed to reactive dyes, but did present with a dermatitis from wearing a dark cotton garment. The patient experienced reactivation of his dermatitis when rewearing a new unwashed dark T- shirt made of 100% cotton (in fact, the patient reported that it had to be washed at least 3 times before the skin reaction disappeared). He presented positive patch tests to 6 reactive dyes from Chemotechnique textile series. The clothing could not be proved as the true cause of the dermatitis, but resolution occurred upon removal of the suspected garment. This suggests that contact allergy to the reactive dyes (he did not react to any other dyes and his garment was a natural fabric)was likely responsible. With this report,we would like to emphasize that reactive dyes, as a class, should be considered as potential allergens, both occupationally and from non- occupational exposure such as garments. If garments containing reactive dyes are not properly rinsed in the manufacturing process, we believe that excess of dye can be retained that may cause allergic contact dermatitis (ACD). As the reactive dyes and their hydrolysis products are very water- soluble, they can be easily washed off to prevent ACD.
