Superfici alacral fibromyxoma(SAFM)is arecently recognized myxoid tumor that u sually occurs on the fingers and toes of middle-aged adults. We report on the t ypical case of a 50-yearold woman with a SAFM in the right...Superfici alacral fibromyxoma(SAFM)is arecently recognized myxoid tumor that u sually occurs on the fingers and toes of middle-aged adults. We report on the t ypical case of a 50-yearold woman with a SAFM in the right big toenail that had been slowly growing for more than 10 years. To our knowledge, this case is the first reported case for which clinical pictures are available. Histologically, t he lesion was non-encapsulated and was composed of stellate and spindle cells, arranged in a myxoid matrix. No atypia or mitotic figures were found. Neoplastic cells showed positive staining for CD34 and negative staining for epithelial me mbrane antigen (EMA), actin, desmin, keratins, S100 protein, CD99, and HMB45. Di fferential diagnosis encompasses benign and malignant myxoid and spindle cells t umors such as myxoid neurofibroma, sclerosing perineurioma, superficial angiomyx oma, and several low-grade myxoid sarcomas.展开更多
文摘Superfici alacral fibromyxoma(SAFM)is arecently recognized myxoid tumor that u sually occurs on the fingers and toes of middle-aged adults. We report on the t ypical case of a 50-yearold woman with a SAFM in the right big toenail that had been slowly growing for more than 10 years. To our knowledge, this case is the first reported case for which clinical pictures are available. Histologically, t he lesion was non-encapsulated and was composed of stellate and spindle cells, arranged in a myxoid matrix. No atypia or mitotic figures were found. Neoplastic cells showed positive staining for CD34 and negative staining for epithelial me mbrane antigen (EMA), actin, desmin, keratins, S100 protein, CD99, and HMB45. Di fferential diagnosis encompasses benign and malignant myxoid and spindle cells t umors such as myxoid neurofibroma, sclerosing perineurioma, superficial angiomyx oma, and several low-grade myxoid sarcomas.
