The aim of our study was to evaluate severity of hirsutism, assessed via the Ferriman-Gallwey scoring system in 12 different androgen-sensitive skin areas among 65 consecutive hirsute patients with functional androgen...The aim of our study was to evaluate severity of hirsutism, assessed via the Ferriman-Gallwey scoring system in 12 different androgen-sensitive skin areas among 65 consecutive hirsute patients with functional androgen excess (polycystic ovary syndrome and idiopathic hirsutism) from the Central Anatolian region of Turkey. Results of this descriptive study showed that the buttocks/perineum, sideburn, and neck areas greatly contributed to the total hirsutism score, rather than the upper arm, upper back, and upper abdomen.展开更多
Objective: To describe a case of twin gestation that occurred in both horns of a bicornuate uterus after the administration of clomiphene citrate and bromocriptine. Design: Case report. Setting: Department of Obstetri...Objective: To describe a case of twin gestation that occurred in both horns of a bicornuate uterus after the administration of clomiphene citrate and bromocriptine. Design: Case report. Setting: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Korea. Patient(s): A 34-year-old woman presented with secondary infertility and hyperprolactinemia. Intervention(s): Bromocriptine, 2.5 mg/day, was administered immediately, and clomiphene citrate, 150 mg/day, was started from menstruation day 5 for 5 days. Main Outcome Measure(s): The establishment of pregnancy and obstetric outcome. Result(s): A nonidentical twin pregnancy occurred but ended in preterm delivery at 24 weeks. One baby has survived for over 3 months. Conclusion(s): Twin gestation can occur in both horns of a bicornuate uterus after clomiphene citrate administration.展开更多
In the present nonrandomized pilot study we determined the role of the vaginally administered aromatase inhibitor anastrozole (0.25 mg anastrozole/d for 6 months) in the treatment of women with histologically proven r...In the present nonrandomized pilot study we determined the role of the vaginally administered aromatase inhibitor anastrozole (0.25 mg anastrozole/d for 6 months) in the treatment of women with histologically proven rectovaginal endometriosis. In a series of 10 patients, dysmenorrhea, physical and social functioning, but not chronic pelvic pain and dyspareunia, improved during therapy.展开更多
Objective: To investigate whether seminatural cycle is a reasonable management for ovarian aging patients. Design: Prospective study. Setting: ART Unit, Clamart, France. Patient(s): Seventy-five women, 158 cycles. Int...Objective: To investigate whether seminatural cycle is a reasonable management for ovarian aging patients. Design: Prospective study. Setting: ART Unit, Clamart, France. Patient(s): Seventy-five women, 158 cycles. Intervention(s): Infertile women who presented with ovarian aging (defined as low ovarian reserve and characterized by cycle day 3 high FSH, high E2, and/or low inhibin B and/or previous cycle cancellations due to poor ovarian response to COH) were studied. Patients were offered up to three cycles. Treatment was scheduled as follows. From cycle day 8 onward the selection of the dominant follicle was monitored by ultrasound and hormonal measurements. When the dominant follicle appeared, patients received GnRH antagonist and, thereafter, hMG to support further follicular development. Main Outcome Measure(s): Implantation rate and clinical pregnancy. Result(s): Twenty-eight of 158 cycles were cancelled (17.7%). Oocyte pickups were performed in 119 (75.3%) cycles, 91 (57.6%) mature oocytes were retrieved, and 67 (42.4%) embryos transferred. Nineteen clinical pregnancies were obtained; the cumulative pregnancy rate per patient, after 3 cycles, was 35.2%. Conclusion(s): Use of a seminatural cycle is a reasonable management for patients with ovarian aging who have ovulatory menstrual cycles. It achieves a high implantation rate (28.3%).展开更多
The present study was designed to explore the association between estrogen receptor-αgene polymorphism and the risk of endometriosis by investigating the frequecy of PvuII, XbaI, and thymine-adenine (TA) repeat polym...The present study was designed to explore the association between estrogen receptor-αgene polymorphism and the risk of endometriosis by investigating the frequecy of PvuII, XbaI, and thymine-adenine (TA) repeat polymorphisms in patients with and without endometriosis in a Korean population. Although there was no significant difference in the allele distribution and frequency of either PvuII or XbaI polymorphisms between endometriosis patients and control subjects, patients with stage I/II endometriosis showed a higher incidence of alleles with fewer (TA)n repeats (12-15 repeats) compared with controls.展开更多
Conjugated equine estrogen alone or combined with medroxyprogesterone acetate lowered homocysteine levels in postmenopausal women. Regardless of the dosage of progestin used, there was no impact on homocysteine metabo...Conjugated equine estrogen alone or combined with medroxyprogesterone acetate lowered homocysteine levels in postmenopausal women. Regardless of the dosage of progestin used, there was no impact on homocysteine metabolism after 3 years of therapy.展开更多
A history of male fertility is not an accurate predictor of a normal semen analysis result. The semen analysis should remain part of the evaluation of the infertile couple even in cases where a history of male fertili...A history of male fertility is not an accurate predictor of a normal semen analysis result. The semen analysis should remain part of the evaluation of the infertile couple even in cases where a history of male fertility is reported.展开更多
文摘The aim of our study was to evaluate severity of hirsutism, assessed via the Ferriman-Gallwey scoring system in 12 different androgen-sensitive skin areas among 65 consecutive hirsute patients with functional androgen excess (polycystic ovary syndrome and idiopathic hirsutism) from the Central Anatolian region of Turkey. Results of this descriptive study showed that the buttocks/perineum, sideburn, and neck areas greatly contributed to the total hirsutism score, rather than the upper arm, upper back, and upper abdomen.
文摘Objective: To describe a case of twin gestation that occurred in both horns of a bicornuate uterus after the administration of clomiphene citrate and bromocriptine. Design: Case report. Setting: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Korea. Patient(s): A 34-year-old woman presented with secondary infertility and hyperprolactinemia. Intervention(s): Bromocriptine, 2.5 mg/day, was administered immediately, and clomiphene citrate, 150 mg/day, was started from menstruation day 5 for 5 days. Main Outcome Measure(s): The establishment of pregnancy and obstetric outcome. Result(s): A nonidentical twin pregnancy occurred but ended in preterm delivery at 24 weeks. One baby has survived for over 3 months. Conclusion(s): Twin gestation can occur in both horns of a bicornuate uterus after clomiphene citrate administration.
文摘In the present nonrandomized pilot study we determined the role of the vaginally administered aromatase inhibitor anastrozole (0.25 mg anastrozole/d for 6 months) in the treatment of women with histologically proven rectovaginal endometriosis. In a series of 10 patients, dysmenorrhea, physical and social functioning, but not chronic pelvic pain and dyspareunia, improved during therapy.
文摘Objective: To investigate whether seminatural cycle is a reasonable management for ovarian aging patients. Design: Prospective study. Setting: ART Unit, Clamart, France. Patient(s): Seventy-five women, 158 cycles. Intervention(s): Infertile women who presented with ovarian aging (defined as low ovarian reserve and characterized by cycle day 3 high FSH, high E2, and/or low inhibin B and/or previous cycle cancellations due to poor ovarian response to COH) were studied. Patients were offered up to three cycles. Treatment was scheduled as follows. From cycle day 8 onward the selection of the dominant follicle was monitored by ultrasound and hormonal measurements. When the dominant follicle appeared, patients received GnRH antagonist and, thereafter, hMG to support further follicular development. Main Outcome Measure(s): Implantation rate and clinical pregnancy. Result(s): Twenty-eight of 158 cycles were cancelled (17.7%). Oocyte pickups were performed in 119 (75.3%) cycles, 91 (57.6%) mature oocytes were retrieved, and 67 (42.4%) embryos transferred. Nineteen clinical pregnancies were obtained; the cumulative pregnancy rate per patient, after 3 cycles, was 35.2%. Conclusion(s): Use of a seminatural cycle is a reasonable management for patients with ovarian aging who have ovulatory menstrual cycles. It achieves a high implantation rate (28.3%).
文摘The present study was designed to explore the association between estrogen receptor-αgene polymorphism and the risk of endometriosis by investigating the frequecy of PvuII, XbaI, and thymine-adenine (TA) repeat polymorphisms in patients with and without endometriosis in a Korean population. Although there was no significant difference in the allele distribution and frequency of either PvuII or XbaI polymorphisms between endometriosis patients and control subjects, patients with stage I/II endometriosis showed a higher incidence of alleles with fewer (TA)n repeats (12-15 repeats) compared with controls.
文摘Conjugated equine estrogen alone or combined with medroxyprogesterone acetate lowered homocysteine levels in postmenopausal women. Regardless of the dosage of progestin used, there was no impact on homocysteine metabolism after 3 years of therapy.
文摘A history of male fertility is not an accurate predictor of a normal semen analysis result. The semen analysis should remain part of the evaluation of the infertile couple even in cases where a history of male fertility is reported.
