We report on the incidence of adverse cardiac events in 350 patients who underwent noncardiac surgery within 2 months of successful balloon angioplasty(BA) at our institution between 1988 and 2001. Three patients died...We report on the incidence of adverse cardiac events in 350 patients who underwent noncardiac surgery within 2 months of successful balloon angioplasty(BA) at our institution between 1988 and 2001. Three patients died perioperatively(n=1) or had myocardial infarction(n=2)(0.9%, 95%confidence interval[CI] 0.2%to 2.5%), which is a lower incidence than that reported for patients undergoing noncardiac surgery after stenting(3.9%to 32%). One patient died, and 2 had a nonfatal myocardial infarction. All 3(1.6%, 95%CI 0.3%to 4.6%)were among the 188 patients who underwent surgery within 2 weeks of BA. Repeat target vessel revascularization was performed in 10 patients(2.9%, 95%CI 1.4%to 5.2%): in 3(1.6%, 95%CI 0.3%to 4.6%) of 188 patients who underwent surgery within 2 weeks of BA and in 7(5.1%, 95%CI 2.1%to 10.2%) of 138 patients who underwent surgery within 3 to 7 weeks of BA. Therefore, in patients in whom percutaneous coronary revascularization is required before noncardiac surgery, BA appears to be safe, especially in patients who need to undergo surgery early after percutaneous coronary intervention.展开更多
This study examined the incremental cost-effectiveness of extending clopidogrel therapy from one month to one year after percutaneous coronary intervention(PCI) in an unselected, heterogeneous patient population. Clin...This study examined the incremental cost-effectiveness of extending clopidogrel therapy from one month to one year after percutaneous coronary intervention(PCI) in an unselected, heterogeneous patient population. Clinical trials suggest that prolonging clopidogrel therapy for up to one year after PCI reduces downstream cardiac events. However, clopidogrel therapy is costly and may increase bleeding risk. Using decision analysis, we compared the outcomes and cost of prolonging clopidogrel treatment from one month to one year after PCI with the alternative strategy of discontinuing therapy one month after the procedure. Event rates were based on 3,976 PCI patients who were treated between January 1999 and December 2001 at the Duke Medical Center and received no more than one month of clopidogrel after the procedure. Baseline characteristics and event rates were obtained from Duke clinical information systems. The effect of prolonged clopidogrel therapy on event rates was based on the Clopidogrel for the Reduction of Events During Observation(CREDO) trial per-protocol data. Unit costs and the effect of myocardial infarction(MI) on life expectancy were based on published sources. Extending clopidogrel therapy from one month to one year after PCI cost ＄879 per patient and reduced the risk of MI by 2.6%. Assuming MI decreases life expectancy by two years, prolonged therapy would cost ＄15,696 per year of life saved. Economic attractiveness of therapy varied with baseline risk, the effect of prolonged therapy on MI risk, and the price of clopidogrel. Prolonging clopidogrel therapy for one year after PCI is economically attractive, particularly in high-risk patients.展开更多
文摘We report on the incidence of adverse cardiac events in 350 patients who underwent noncardiac surgery within 2 months of successful balloon angioplasty(BA) at our institution between 1988 and 2001. Three patients died perioperatively(n=1) or had myocardial infarction(n=2)(0.9%, 95%confidence interval[CI] 0.2%to 2.5%), which is a lower incidence than that reported for patients undergoing noncardiac surgery after stenting(3.9%to 32%). One patient died, and 2 had a nonfatal myocardial infarction. All 3(1.6%, 95%CI 0.3%to 4.6%)were among the 188 patients who underwent surgery within 2 weeks of BA. Repeat target vessel revascularization was performed in 10 patients(2.9%, 95%CI 1.4%to 5.2%): in 3(1.6%, 95%CI 0.3%to 4.6%) of 188 patients who underwent surgery within 2 weeks of BA and in 7(5.1%, 95%CI 2.1%to 10.2%) of 138 patients who underwent surgery within 3 to 7 weeks of BA. Therefore, in patients in whom percutaneous coronary revascularization is required before noncardiac surgery, BA appears to be safe, especially in patients who need to undergo surgery early after percutaneous coronary intervention.
文摘This study examined the incremental cost-effectiveness of extending clopidogrel therapy from one month to one year after percutaneous coronary intervention(PCI) in an unselected, heterogeneous patient population. Clinical trials suggest that prolonging clopidogrel therapy for up to one year after PCI reduces downstream cardiac events. However, clopidogrel therapy is costly and may increase bleeding risk. Using decision analysis, we compared the outcomes and cost of prolonging clopidogrel treatment from one month to one year after PCI with the alternative strategy of discontinuing therapy one month after the procedure. Event rates were based on 3,976 PCI patients who were treated between January 1999 and December 2001 at the Duke Medical Center and received no more than one month of clopidogrel after the procedure. Baseline characteristics and event rates were obtained from Duke clinical information systems. The effect of prolonged clopidogrel therapy on event rates was based on the Clopidogrel for the Reduction of Events During Observation(CREDO) trial per-protocol data. Unit costs and the effect of myocardial infarction(MI) on life expectancy were based on published sources. Extending clopidogrel therapy from one month to one year after PCI cost ＄879 per patient and reduced the risk of MI by 2.6%. Assuming MI decreases life expectancy by two years, prolonged therapy would cost ＄15,696 per year of life saved. Economic attractiveness of therapy varied with baseline risk, the effect of prolonged therapy on MI risk, and the price of clopidogrel. Prolonging clopidogrel therapy for one year after PCI is economically attractive, particularly in high-risk patients.
