Considerations for exerkine research focusing on the response to exercise training

García-Hermoso and colleagues1 recently published a systematic literature review and meta-analysis on exercise training-induced changes in exerkine concentrations in type 2diabetes mellitus patients,providing a contemporary view on how exerkines respond to exercise training.That review prompted us to highlight 2 additional considerations that should be taken into account when studying the response of exerkines to exercise training.Firstly,whether exerkines can exhibit discordant responses to acute exercise compared to exercise training,and secondly,the need to consider the residual effects of the most recent exercise bout.

Identification of the Breach of Short-Term Rental Regulations in Irish Rent Pressure Zones

The housing crisis in Ireland has rapidly grown in recent years. To make a more significant profit, many landlords are no longer renting out their houses under long-term tenancies but under short-term tenancies. Regulating rentals in Rent Pressure Zones with the highest and rising rents is becoming a tricky issue. In this paper, we develop a breach identifier to check short-term rentals located in Rent Pressure Zones with potential breaches only using publicly available data from Airbnb (an online marketplace focused on short-term home-stays) and Irish government websites. First, we use a Residual Neural Network to filter out outdoor landscape photos that negatively impact identifying whether an owner has multiple rentals in a Rent Pressure Zone. Second, a Siamese Neural Network is used to compare the similarity of indoor photos to determine if multiple rental posts correspond to the same residence. Next, we use the Haversine algorithm to locate short-term rentals within a circle centered on the coordinate of a permit. Short-term rentals with a permit will not be restricted. Finally, we improve the occupancy estimation model combined with sentiment analysis, which may provide higher accuracy.

Associations between meeting 24-hour movement guidelines and quality of life among children and adolescents with autism spectrum disorder

Background:The Canadian 24-hour movement behavior(24-HMB)guidelines suggest that a limited amount of screen time use,an adequate level of physical activity(PA),and sufficient sleep duration are beneficial for ensuring and optimizing the health and quality of life(QoL)of children and adolescents.However,this topic has yet to be examined for children and adolescents with autism spectrum disorder(ASD)specifically.The aim of this cross-sectional observational study was to examine the associations between meeting 24-HMB guidelines and several QoLrelated indicators among a national sample of American children and adolescents with ASD.Methods:Data were taken from the 2020 U.S.National Survey of Children’s Health dataset.Participants(n=956)aged 617 years and currently diagnosed with ASD were included.The exposure of interest was adherence to the 24-HMB guidelines.Outcomes were QoL indicators,including learning interest/curiosity,repeating grades,adaptive ability,victimization by bullying,and behavioral problems.Categorical variables were described with unweighted sample counts and weighted percentages.Age,sex,race,preterm birth status,medication,behavioral treatment,household poverty level,and the educational level of the primary caregivers were included as covariates.Odds ratio(OR)and 95%confidence interval(95%CI)were used to present the strength of association between adherence to 24-HMB guidelines and QoL-related indicators.Results:Overall,452 participants(45.34%)met 1 of the 3 recommendations,216(22.65%)met 2 recommendations,whereas only 39 participants(5.04%)met all 3 recommendations.Compared with meeting none of the recommendations,meeting both sleep duration and PA recommendations(OR=3.92,95%CI:1.639.48,p<0.001)or all 3 recommendations(OR=2.11,95%CI:1.034.35,p=0.04)was associated with higher odds of showing learning interest/curiosity.Meeting both screen time and PA recommendations(OR=0.15,95%CI:0.040.61,p<0.05)or both sleep duration and PA recommendations(OR=0.24,95%CI:0.070.87,p<0.05)was associated with lower odds of repeating any grades.With respect to adaptive ability,participants who met only the PA recommendation of the 24-HMB were less likely to have difficulties dressing or bathing(OR=0.11,95%CI:0.020.66,p<0.05)than those who did not.For participants who met all 3 recommendations(OR=0.38,95%CI:0.150.99,p=0.05),the odds of being victimized by bullying was lower.Participants who adhered to both sleep duration and PA recommendations were less likely to present with severe behavioral problems(OR=0.17,95%CI:0.040.71,p<0.05)than those who did not meet those guidelines.Conclusion:Significant associations were found between adhering to 24-HMB guidelines and selected QoL indicators.These findings highlight the importance of maintaining a healthy lifestyle as a key factor in promoting and preserving the QoL of children with ASD.

Meta-analysis of CO_(2) conversion,energy efficiency,and other performance data of plasma-catalysis reactors with the open access PIONEER database

This paper brings the comparison of performances of CO_(2)conversion by plasma and plasma-assisted catalysis based on the data collected from literature in this field,organised in an open access online database.This tool is open to all users to carry out their own analyses,but also to contributors who wish to add their data to the database in order to improve the relevance of the comparisons made,and ultimately to improve the efficiency of CO_(2)conversion by plasma-catalysis.The creation of this database and database user interface is motivated by the fact that plasma-catalysis is a fast-growing field for all CO_(2)conversion processes,be it methanation,dry reforming of methane,methanolisation,or others.As a result of this rapid increase,there is a need for a set of standard procedures to rigorously compare performances of different systems.However,this is currently not possible because the fundamental mechanisms of plasma-catalysis are still too poorly understood to define these standard procedures.Fortunately however,the accumulated data within the CO_(2)plasma-catalysis community has become large enough to warrant so-called“big data”studies more familiar in the fields of medicine and the social sciences.To enable comparisons between multiple data sets and make future research more effective,this work proposes the first database on CO_(2)conversion performances by plasma-catalysis open to the whole community.This database has been initiated in the framework of a H_(2)0_(2)0 European project and is called the“PIONEER Data Base”.The database gathers a large amount of CO_(2)conversion performance data such as conversion rate,energy efficiency,and selectivity for numerous plasma sources coupled with or without a catalyst.Each data set is associated with metadata describing the gas mixture,the plasma source,the nature of the catalyst,and the form of coupling with the plasma.Beyond the database itself,a data extraction tool with direct visualisation features or advanced filtering functionalities has been developed and is available online to the public.The simple and fast visualisation of the state of the art puts new results into context,identifies literal gaps in data,and consequently points towards promising research routes.More advanced data extraction illustrates the impact that the database can have in the understanding of plasma-catalyst coupling.Lessons learned from the review of a large amount of literature during the setup of the database lead to best practice advice to increase comparability between future CO_(2)plasma-catalytic studies.Finally,the community is strongly encouraged to contribute to the database not only to increase the visibility of their data but also the relevance of the comparisons allowed by this tool.

珠海市社区居民高尿酸血症流行病学调查及其与慢性肾脏病的相关性

目的:了解珠海市社区居民中高尿酸血症(hyperuricemia,HUA)患病率及其与慢性肾脏病(chronic kidney disease,CKD)的关系。方法:选择珠海市城区成年原住居民(n=2135)进行横断面筛查。收集晨尿及抽取空腹血液检测尿液、血生化指标。结果:珠海市社区居民中HUA总患病率为32.41%。CKD总患病率为15.83%。CKD检出率在HUA人群(24.42%)显著高于尿酸正常人群(11.92%),差异有统计学意义(P<0.01)。多元Logistic回归分析显示:血尿酸、年龄、性别、收缩压、空腹血糖、超敏C反应蛋白水平与CKD发病独立相关(P<0.05)。结论:珠海市城区居民HUA及CKD患病率均高于国内其它地区及同一地区7年前的流行病学研究报道。HUA是CKD发病的独立危险因素。

基于聚苯胺纳米纤维的气体传感元件构建及传感性能

在丝网印刷碳电极的0.125 mm绝缘带上直接铺展微观孔径为300～400 nm的聚苯胺(PANI)纳米纤维(直径60 nm)薄膜,构建气体传感元件。通过监测甲苯、乙醇及二氯甲烷蒸气对气体传感元件电阻的影响研究其对挥发性有机溶剂蒸气的传感性能。利用扫描电镜(SEM)分析研究了PANI纳米纤维的形貌。

基于翻译日志的统计机器翻译模型剪枝

提出一种基于翻译日志的统计机器翻译模型的剪枝方法。该方法利用翻译规则在翻译日志中的命中频数对机器翻译规则进行过滤，保留当前机器翻译模型所需的最小规则表。实验表明，该方法能够在仅保留原有模型1％～3％翻译规则的前提下达到原有模型的翻译效果。

健康成人24h尿液细胞外囊泡定量及大小分布

目的研究观察健康成人24 h尿液细胞外囊泡（u EVs）数量、大小分布及个体间差异。方法利用液压透析滤过法分离9名健康成年人24 h u EVs,通过western blot（WB）和透射电镜（TEM）技术验证u EVs的分离效果,应用BCA蛋白定量法及纳米微粒跟踪分析技术分别对富集的u EVs样品进行蛋白定量测定和囊泡数量及大小分布的分析。结果 TEM下可见大小不等、形状不一的囊泡。WB技术检测到外泌体的标记物—人肿瘤易感基因（TSG101）。9名健康成人24 h尿液分离的u EVs样品蛋白定量范围为132.50~760.70 ng/m L。纳米微粒跟踪分析技术检测结果显示24 h u EVs数量为（3.56~5.12）×1012个,CV=14.23%。24 h分泌的u EVs中,直径在〈40 nm范围内的囊泡占所检测到的总囊泡数的0.04~0.69%,数量为（1.80~26.49）×109个;符合外泌体直径范围（40~100 nm）的囊泡占总囊泡数的22.07%~42.08%,数量为（1.00~1.77）×1012个。符合微囊泡直径范围（100~1000 nm）的囊泡约占总囊泡数的57.88%~77.85%,数量为（2.09~3.86）×1012个。结论新型液压透析滤过法能高效、便捷地实现大样本尿液u EVs的分离。健康成人分泌的24 h u EVs个体间差异较小,是u EVs相关研究较理想的标本来源。

基于深度神经网络的语义角色标注

该文提出了一个基于多层长短期记忆神经网络的语义角色标注方法,并装置了新颖的"直梯单元"(elevator unit,EU)。EU包含了对单元内部输入和输出的线性连接,使信息可以通畅地在不同层之间传播。通过EU,一个20层的LSTM网络可以得到比较充分的优化。重要的是,这个线性连接包含的"门"函数可以正则和控制信息在时间方向和空间方向上的传播。不同层次的抽象信息也可以被EU直接带到输出层进行语义角色标注。尽管这个模型非常简单,不需要任何额外的特征输入,但是它取得了理想的实验结果,在CoNLL-2005公开数据集上取得了F=81.56%的结果,在CoNLL-2012公开数据集上取得了F=82.53%的结果,比之前最好的结果分别提高了0.5%和1.26%。另外,在领域外的数据集上我们也取得了F值2.2%的显著提升,这是当前世界上最好的性能。该模型比较简洁,非常容易实现和并行,在单一的K40GPU上取得了每秒11.8K单词的解析速度,远远高于之前的方法。

Multilevel Pattern Mining Architecture for Automatic Network Monitoring in Heterogeneous Wireless Communication Networks

The rapid development of network technology and its evolution toward heterogeneous networks has increased the demand to support automatic monitoring and the management of heterogeneous wireless communication networks.This paper presents a multilevel pattern mining architecture to support automatic network management by discovering interesting patterns from telecom network monitoring data.This architecture leverages and combines existing frequent itemset discovery over data streams,association rule deduction,frequent sequential pattern mining,and frequent temporal pattern mining techniques while also making use of distributed processing platforms to achieve high-volume throughput.

A Parameter-Uniform Finite Difference Method for a Coupled System of Convection-Diffusion Two-Point Boundary Value Problems

A system of m (≥2) linear convection-diffusion two-point boundary value problems is examined,where the diffusion term in each equation is multiplied by a small parameterεand the equations are coupled through their convective and reactive terms via matrices B and A respectively.This system is in general singularly perturbed. Unlike the case of a single equation,it does not satisfy a conventional maximum princi- ple.Certain hypotheses are placed on the coupling matrices B and A that ensure exis- tence and uniqueness of a solution to the system and also permit boundary layers in the components of this solution at only one endpoint of the domain;these hypotheses can be regarded as a strong form of diagonal dominance of B.This solution is decomposed into a sum of regular and layer components.Bounds are established on these compo- nents and their derivatives to show explicitly their dependence on the small parameterε.Finally,numerical methods consisting of upwinding on piecewise-uniform Shishkin meshes are proved to yield numerical solutions that are essentially first-order conver- gent,uniformly inε,to the true solution in the discrete maximum norm.Numerical results on Shishkin meshes are presented to support these theoretical bounds.

QoE-Oriented Resource Allocation for Multiuser-Multiservice Femtocell Networks

The pursuit of high data rate and assurance of quality of experience(QoE) for end users represent the main goals of future wireless communication systems.By introducing MOS(Mean Opinion Score) based assessment models for different types of applications,this paper proposed novel QoE-oriented radio resource allocation(RRA) algorithms for multiuser-multiservice femtocell networks.An optimal QoE-oriented RRA strategy is first analyzed using time-sharing method which is applicable to best effort applications.RRA algorithms based on the cross-layer architecture are then proposed for all types of applications by considering parameters extracted from different layers of networking protocols.In the proposed algorithms,a priority mechanism is employed to ensure fairness.Simulation results show that the proposed algorithms can significantly improve the overall perceived quality from the users' perspective in comparison with traditional Quality of Service(QoS)oriented algorithms.

Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine

AIM To identify mi RNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the intestine.METHODS Exponentially growing Caco-2 and HT-29 cells were harvested and prepared for m RNA, mi RNA and proteomic profiling. m RNA microarray profiling analysis was carried out using the Affymetrix Gene Chip Human Gene 1.0 ST array. mi RNA microarray profiling analysis was carried out using the Affymetrix Genechip mi RNA 3.0 array. Quantitative Label-free LC-MS/MS proteomic analysis was performed using a Dionex Ultimate 3000 RSLCnano system coupled to a hybrid linear iontrap/Orbitrap mass spectrometer. Peptide identities were validated in Proteome Discoverer 2.1 and were subsequently imported into Progenesis QI software for further analysis. Hierarchical cluster analysis for all three parallel datasets(mi RNA, proteomics, m RNA) was conducted in the R software environment using the Euclidean distance measure and Ward's clustering algorithm. The prediction of mi RNA and oppositely correlated protein/m RNA interactions was performed using Target Scan 6.1. GO biological process, molecular function and cellular component enrichment analysis was carried out for the DE mi RNA, protein and m RNA lists via the Pathway Studio 11.3 Web interface using their Mammalian database.RESULTS Differential expression(DE) profiling comparing the intestinal cell lines HT-29 and Caco-2 identified 1795 Genes, 168 Proteins and 160 mi RNAs as DE between the two cell lines. At the gene level, 1084 genes were upregulated and 711 were downregulated in the Caco-2 cell line relative to the HT-29 cell line. At the protein level, 57 proteins were found to be upregulated and 111 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Finally, at the mi RNAs level, 104 were upregulated and 56 downregulated in the Caco-2 cell line relative to the HT-29 cell line. Gene ontology(GO) analysis of the DE m RNA identified cell adhesion, migration and ECM organization, cellular lipid and cholesterol metabolic processes, small molecule transport and a range of responses to external stimuli, while similar analysis of the DE protein list identified gene expression/transcription, epigenetic mechanisms, DNA replication, differentiation and translation ontology categories. The DE protein and gene lists were found to share 15 biological processes including for example epithelial cell differentiation [P value ≤ 1.81613 E-08(protein list); P ≤ 0.000434311(gene list)] and actin filament bundle assembly [P value ≤ 0.001582797(protein list); P ≤ 0.002733714(gene list)]. Analysis was conducted on the three data streams acquired in parallel to identify targets undergoing potential mi RNA translational repression identified 34 proteins, whose respective m RNAs were detected but no change in expression was observed. Of these 34 proteins, 27 proteins downregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 19 unique anti-correlated/upregulated micro RNAs and 7 proteins upregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 15 unique anti-correlated/downregulated micro RNAs.CONCLUSION This first study providing "tri-omics" analysis of the principal intestinal cell line models Caco-2 and HT-29 has identified 34 proteins potentially undergoing mi RNA translational repression.

Electron Density and Optical Emission Measurements of SF_6/O_2 Plasmas for Silicon Etch Processes

This work investigates internal plasma process parameters using a hairpin resonance probe and optical emission spectroscopy. The dependence of electron density and atomic fluorine on the percentage of oxygen in an SF6/O2 discharge was measured using these methods. An RIE Oxford Instruments 80 plus chamber was used for the experiments. Two different process powers （100 W and 300 W） at a constant pressure （100 mTorr） were used, and it was found that the optical emission intensity of the 703.7 nm and 685.6 nm lines of atomic fluorine increased rapidly as oxygen was added to the SF6 discharge, reached their maximum at an O2 fraction of 20% and then decreased with further addition of oxygen. The plasma electron density was also strongly influenced by the addition of O2.

Plasma Treatment of Natural Jute Fibre by RIE 80 plus Plasma Tool

Plasma treatment can be used to modify the structure of natural fibre like jute for a variety of applications. Environmentally friendly jute fibre was treated with argon and oxygen plasma. The treated samples were characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR） and optical microscope. The macromolecular and microstructural changes in cellulose confirmed the change by plasma treatment. The XRD results confirmed that the crystal size and the crystallinity of the plasma treated fibre increased. Argon plasma treated fibre had a smooth and compact surface, compared to oxygen plasma treated fibre. The maximum stain （i.e. stress） concentrated in the oxygen plasma treated fibre. Optical micrographs showed the oxygen plasma treated fibre tended to rupture due to higher strain （i.e., stress） compared to fibre with argon plasma treatment. FTIR results also provided the evidence of change in the chemical constituents with plasma treatment.

QoE-Driven Energy-Aware Multipath Content Delivery Approach for MPTCP-Based Mobile Phones

Mobile phones equipped with multiple wireless interfaces can increase their goodput performance by making use of concurrent transmissions over multiple paths, enabled by the Multipath TCP(MPTCP). However, utilizing MPTCP for data delivery may generally result in higher energy consumption, while the battery power of a mobile phone is limited. Thus, how to optimize the energy usage becomes very crucial and urgent. In this paper, we propose MPTCP.QE, a novel quality of experience(Qo E).driven energy.aware multipath content delivery approach for MPTCP.based mobile phones. The main idea of MPTCP.QE is described as follows: it first provides an application rate.aware energy.efficient subflow management strategy to tradeoff throughput performance and energy consumption for mobile phones; then uses an available bandwidth.aware congestion window fast recovery strategy to make a sender avoid unnecessary slow.start and utilize wireless resource quickly; and further introduces a novel receiver.driven energy.efficient SACK strategy to help a receiver possible to detect SACK loss timely and trigger loss recovery in a more energy.efficient way. The simulation results show that with the MPTCP.QE, the energy usage is enhanced while the performance level is maintained compared to existing MPTCP solutions.

Secure Video Streaming with Lightweight Cipher PRESENT in an SDN Testbed

The combination of traditional processors and Field Programmable Gate Arrays(FPGA)is shaping the future networking platform for intensive computation in resource-constrained networks and devices.These networks present two key challenges of security and resource limitations.Lightweight ciphers are suitable to provide data security in such constrained environments.Implementing the lightweight PRESENT encryption algorithm in a reconfigurable platform(FPGAs)can offer secure communication service and flexibility.This paper presents hardware acceleration of security primitives in SDN using NETFPGA-10G.We implement an efficient design of the PRESENT algorithm for faster,smaller and lower power consumption hardware circuit using Verilog.We evaluate the performance of the hardware and software implementations of PRESENT.Experimental results prove that the proposed hardware design is a viable option for use in resource constrained devices in future networks and their applications.

Controlled Secure Direct Communication Protocol via the Three-Qubit Partially Entangled Set of States

In this paper,we first re-examine the previous protocol of controlled quantum secure direct communication of Zhang et al.’s scheme,which was found insecure under two kinds of attacks,fake entangled particles attack and disentanglement attack.Then,by changing the party of the preparation of cluster states and using unitary operations,we present an improved protocol which can avoid these two kinds of attacks.Moreover,the protocol is proposed using the three-qubit partially entangled set of states.It is more efficient by only using three particles rather than four or even more to transmit one bit secret information.Given our using state is much easier to prepare for multiqubit states and our protocol needs less measurement resource,it makes this protocol more convenient from an applied point of view.

The Effects of Therapeutic Horseback Riding Program on Motor Skills inChildren with Autism Spectrum Disorder

Therapeutic horseback riding(THR)as an animal-assisted intervention is one of the innovative approaches emer-ging in the treatment for children with autism spectrum disorder(ASD).The current study was designed to inves-tigate the effects of a 12-week,twice a week THR program on motor skills in sixty-eight children with ASD aged 5–10 years old.All participants selected met the DSM-V criteria for ASD,and a total offifty-three participants completed the study.A randomized controlled trial design was utilized for the study.Data was collected via a pre-THR test,interim-THR test,and post-THR test to investigate the possible changes in motor skills throughout the 12-week THR program.Results showed that the THR program significantly improved overall motor skills across time points(p<0.05)and sub-skills of run,gallop and two-hand catch(as compared to the control group,p<0.05).In conclusion,the THR program may be an effective option for improving motor skills in children with ASD and further investigation with a longer period of intervention is warranted.

Analytical and computational modelling for wave energy systems：the example of oscillating wave surge converters

The development of new wave energy converters has shed light on a number of unanswered questions in fluid mechanics, but has also identified a number of new issues of importance for their future deployment. The main concerns relevant to the practical use of wave energy converters are sustainability, survivability, and maintainability. Of course,it is also necessary to maximize the capture per unit area of the structure as well as to minimize the cost. In this review, we consider some of the questions related to the topics of sustainability, survivability, and maintenance access, with respect to sea conditions, for generic wave energy converters with an emphasis on the oscillating wave surge converter. New analytical models that have been developed are a topic of particular discussion. It is also shown how existing numerical models have been pushed to their limits to provide answers to open questions relating to the operation and characteristics of wave energy converters.