Safety of butylphthalide and edaravone in patients with ischemic stroke:a multicenter real-world study

BACKGROUND Butylphthalide(NBP)and edaravone(EDV)injection are common acute ischemic stroke medications in China,but there is a lack of large real-world safety studies on them.This study aimed to determine the incidence of adverse events,detect relevant safety signals,and assess the risk factors associated with these medications in real-world populations.METHODS In this study,data of acute ischemic stroke patients were extracted from the electronic medical record database of six tertiary hospitals between January 2019 and August 2021.Baseline confounders were eliminated using propensity score matching.The drugs’safety was estimated by comparing the results of 24 laboratory tests standards on liver function,kidney function,lipid level,and coagulation function.The drugs’relative risk was estimated by logistic regression.A third group with patients who did not receive NBP or EDV was constructed as a reference.Prescription sequence symmetry analysis was used to evaluate the associations between adverse events and NBP and EDV,respectively.RESULTS 81,292 patients were included in this study.After propensity score matching,the NBP,EDV,and third groups with 727patients in each group.Among the 15 test items,the incidence of adverse events was lower in the NBP group than in the EDV group,and the differences were statistically significant.The multivariate logistic regression equation revealed that NBP injection was not a promoting factor for abnormal laboratory test results,whereas EDV had statistically significant effects on aspartate transaminase,low-density lipoprotein cholesterol and total cholesterol.Prescription sequence symmetry analysis showed that NBP had a weak correlation with abnormal platelet count.EDV had a positive signal associated with abnormal results in gamma-glutamyl transferase,alanine aminotransferase,aspartate aminotransferase,prothrombin time,and platelet count.CONCLUSIONS In a large real-world population,NBP has a lower incidence of adverse events and a better safety profile than EDV or other usual medications.

Spatiotemporal variations,influencing factors,and configurational promotion paths of energy efficiency in China’s cities

The promotion of energy efficiency(EE)helps address energy constraints and promote environmental sustainability.This study comprehensively explores the spatiotemporal variations,influencing factors,and configuration promotion paths of EE in 284 Chinese cities during 2003‒2019 using the global super-efficiency minimum distance to strong efficient frontier(G-S-MinDS),exploratory spatial data analysis(ESDA),multiscale geographically weighted regression(MGWR),and fuzzy set qualitative comparative analysis(fsQCA)methods.The findings are:①China’s cities have an annual average EE of 0.658 with a growth rate of 0.53%,showing considerable promotion potential.②Industrial structure optimization,population agglomeration,economic development,and increased green coverage contribute positively,while government intervention and openness hinder China’s urban EE.③Four configurational promotion paths for enhancing China’s urban EE are identified,where among those paths population density is a core condition,while government intervention is not.This study provides valuable insights into substantially improving urban EE,emphasizing the need for targeted policies to address energy and environmental crises in China.

日本的全球安全发展问题探析

Against the backdrop of the current international situation,which remains complex and fast-changing, Japan dances to America's tune, attempting to rebuild its industrial power featuring “strategic indispensability,” establish resource power based on the independent and stable supply of strategic materials, and construct normative power to influence or even dominate the international economic order. Such an approach closely echoes the current three strategic preferences of Japan:re-emergence as a global power has been Japan's long-held political aspiration, conservatism defines the country's way of thinking, and liberalization and openness reflect realistic needs. Japan relies excessively on conservative thinking, overemphasizes “small security,” and stresses “strategic autonomy.” However, the greater importance it places on security, the less secure it will become. Similarly, decoupling and supply chain disruption will only retard the development of Japan, pushing the country into the trap of Braess' s Paradox. The rise of the East, the decline of the West, and the advent of the Asian century are historical trends.Japan cannot achieve secure development in isolation from Asia and the East, much less from China.

Understanding livelihood vulnerability:a perspective from Western Sichuan’s ethnic rural settings

To explore the livelihood status and key influencing factors of rural households in the minority areas,we collected flat data from 284 rural households in 32 villages across 12 counties of Western Sichuan from 2021 to 2022.We conducted participatory household survey on the livelihood status of the rural households and try to identify the key factors to influence their livelihood vulnerability using multiple linear regression.The results showed that:the livelihood situation of the rural households is relatively vulnerable.The vulnerability varies significantly with the income levels,education levels,and income sources.The vulnerability of farm households,categorized from low to high livelihood types,follows the sequence:non-agricultural dominant households,non-agricultural households,agricultural dominant households,and pure agricultural households.The degree of damage to the natural environment,education costs,loan opportunities,the proportion of agricultural income to annual household income,and the presence of sick people in the household have significant positive effects on the livelihood vulnerability index(LVI)of rural households;while help from relatives and friends,net income per capita,household size,household education,agricultural land area,participation in industrial organizations,number of livestock,purchase of commercial houses,drinking water source,and self-supply of food have significant negative effects.Based on the findings,we believe that local rural households operate in a complex livelihood system and recommend continuous interventions targeting key influences to provide empirical research support for areas facing similar situations.

Empirical research on the international spillover effects of U.S. monetary policy and their impacts

Empirical research has shown that there were international spillover effects from the U.S. monetary policy to output level, net exports and price levels of each country, and the impact on prices in each country was of synchronous effect. The structural impulse response analysis showed that U.S. monetary policy could improve U.S. income and payment without damaging U.S. economic growth, but the shocks negatively affected the economic growth in the rest of the world. Hence, it's important to pay close attention to the moral risks of U.S. monetary policy to evade the global shocks caused by the "benefit-itself-at-the-expense-of-others" polices of the American government. Besides these findings, U.S. monetary policy shocks strongly affect China's trade surplus fluctuations. Based on this, we propose that the approaches of balancing China's current account could be explored efficiently from the perspective of monetary policy.

A Comparative Assessment of Patient Safety Culture between Iranian Selected Hospitals and Agency for Healthcare Research and Quality (AHRQ) Report

Establishing a culture of patient safety can be effective in reducing the incidence of medical errors and solving concerns of safety inadequacy in health systems. The purpose of this study was to assess the culture of patient safety in the selected hospitals, and compare the results with published reports of AHRQ. This study was approved by the Ethical Committee of BPUMS. The subjects signed the informed consent form to participle in the study. Confidentiality was maintained throughout the study reports. Cross-sectional study was conducted in 2012;the study sample was composed of 364 staffs working at two selected hospitals affiliated to Bushehr University of Medical Sciences. Hospital Survey on Patient Safety Culture was used to collect data. Descriptive statistical analysis was used to analyze the data. No reports of events in both studied hospitals and benchmark were accounted for the most of the reported errors, although this indicator in studied hospitals was nearly 23% higher than that of the benchmark report. The highest patient safety grade in studied hospitals and benchmark was “acceptable” and “very good”, respectively. The highest percentage of positive response to patient safety dimension was organization learning and then teamwork within units in studied hospitals. Teamwork within units also was the highest average percent in benchmark report. Non-punitive response to errors had the lowest positive percentage of participant responses in both studies. To achieve the patient safety culture, we do not need to blame individual and apply punitive approach when errors occur. This makes person accept responsibility for their actions honestly and report errors in a timely manner to prevent reoccurrence of similar errors.

RESEARCH ON THE COASTAL DEVELOPMENT STRATEGY IN CHINA: TAKE SHANDONG PROVINCE AS AN EXAMPLE

Nowadays in China, the coastal development strategy (CDS) aims to make the region (with population 160 million) ahead of developing export-oriented economy and to promote the inland economic prosperity at the same time.The paper analyzes the CDS based on the background of coastal area and the situation at home and abroad, and mainly discusses the relevant tactics in Shandong Province, China.

Research on the Green Culture of Chinese Enterprise

According to the general tendency of the development of enterprise cultural in the 21st century, more and more intense attentions will be paid on the enterprise culture. Thus, while the world green tendency and the green demand rise increasingly, the research on the green cultural management is becoming more important. The study of the green cultural management is not only of vital significance in promoting the continuous development of social economy, but also exchanging the way of the economic growth from extensive pattern to intensive pattern, improving the capacity of the competition and economic benefit of the company, and accelerating the international business. Moreover, the research has another significant importance in enriching and developing the science of enterprise of management.

Research on mechanism of technological diffusion in indus-try cluster

The main aim of the paper is to explain the reason and mechanism of technological diffusion in industry cluster. Following the idea showed in Zhou Qin’s model, we further develop the theoretical analysis that how the technological gap between strong enterprises and weak enterprises determines the level and speed of technological diffusion. The bigger the technological disparity between strong enterprise and weak enterprise is, the quicker technology spreads and knowledge overflows; on the contrary, the smaller the technological disparity between strong enterprise and weak enterprise is, the slower technology spread and knowledge overflows. Therefore, this kind of mechanism is helpful for enterprises in an industry cluster to learn from each other and to enable each enterprise close to the “the average level” of technology or knowledge. As a result, we think that, there exists a close relation between technological gap and technological diffusion. The paper puts forward the way of knowledge overflows of the strong enterprises: imitation- demonstration effect, the longitudinal connection in the industrial chain, the labor force flow and transfer, informal exchange.

Highly cited publication performance in the ophthalmology category in the Web of Science database:a bibliometric analysis

AIM:To determine and evaluate the features of highly cited articles(HCAs)in the ophthalmology category in the Science Citation Index Expanded(SCI-EXPANDED)from 1991 to 2020.METHODS:The Web of Science Core Collection documents with at least 100 citations from their publication year until December 31,2020,were evaluated as highly cited.The examined features were the distribution of yearly output and its average number of per publication,HCAs,authors,institutions,journals,and nations.The publication performance of nations and organizations was assessed using six publication indicators.The Y-index was employed to compare the research outputs of various authors.RESULTS:Publications that had cited the most references were highly published in high-impact factor journals.The United States of America came out on top across all six publication indicators,and it was home to eight of the top 10 most productive institutions.The articles written by Breivik et al(2006)and Farrar et al(2001)were highly cited and had a significant impact in 2020.The authors had a higher number of highly cited articles published as corresponding authors than as first authors.CONCLUSION:The findings of the present study highlight the current scope of global research in ophthalmology.The findings can help policy-makers and advisory groups of research centers to develop future policies.In addition,the findings can guide researchers in this field.

安徽西冲钼矿床细粒花岗岩的岩石定年、岩石化学及与成矿的关系研究

西冲钼矿是大别成矿带东段近年新发现的斑岩型钼-多金属矿床,其矿床学和矿床地球化学研究少见报导。该研究成果丰富了我国斑岩-矽卡岩型钼钨-多金属矿床研究成果,同时对指导区域找矿具有一定意义。本文在详细的野外地质调研基础上,对大别成矿带西冲钼矿区出露的主要岩石单元、矿化和蚀变特征、细粒花岗岩的岩石学、岩石化学和成岩年代学进行了系统的研究。结果表明,矿区出露的主要侵入岩单元由老至新依次为:石英二长岩、细粒花岗岩(130.8±1.1Ma)及双峰式脉岩组合(131.9±1.4Ma和131.3±1.6Ma),其均为燕山期岩浆活动产物,产于华北与扬子陆块拼合后的陆内环境。矿化类型以脉状、网脉状和浸染状为主,为一斑岩型钼-多金属矿床。矿区蚀变发育,包括黑云母-磁铁矿化、钾长石化、硅化、石英-绢云母化、石英-绿帘石化、绿泥石-碳酸盐化和泥化,且空间上具有一定的分带规律。矿区已知矿化、蚀变及Cu-Mo化探异常的空间展布与细粒花岗岩关系密切,且细粒花岗岩中具有高的Mo含量,表明该矿床的形成主要与细粒花岗岩有关。岩石化学结果表明,细粒花岗岩属过铝质-准铝质、高钾钙碱性-钾玄质过渡岩石,锆石U-Pb年龄与双峰式脉岩的在误差范围内一致,表明其均形成于大别造山带大规模伸展背景。

中国牙鲆养殖的成本收益分析

论文以对辽宁省、河北省、天津市以及山东省等鲆鲽类主产区养殖户的分层整群抽样调查数据为基础,对不同养殖模式下牙鲆养殖的投入产出经济效益、市场风险抵抗能力进行了深入分析。结果表明:(1)池塘模式下牙鲆单位产量养殖成本为26.89元/公斤,较工厂化与网箱模式分别节省了5.5元/公斤和8.97元/公斤;(2)牙鲆养殖业的固定成本与可变成本在总成本中所占比例在三种模式下差异比较大;(3)牙鲆工厂化模式中单位产量的成本利润率为67.57%,池塘模式下为57.12%,而网箱模式下仅为11.55%;(4)在市场风险抵抗能力方面,工厂化模式最大,池塘模式居中,网箱养殖最小。基于以上研究结论,提出通过鼓励工厂化养殖模式的发展、重点控制产品价格、饲料成本、苗种成本从而最终提高养殖效益等建议。

辽宁省生态足迹地理分布及其可持续发展分析(英文)

This paper presents the detailed results and analyses on the ecological footprints and bio-capacities of the individual cities and the province as a whole for the year 2001, providing a clear picture of sustainability for the province. Results show that the ecological footprints of most cities in Liaoning exceeded their respective bio-capacities, incurring high ecological deficits. The ecological deficit of the province as a whole was 1.31 ha/cap. Those cities with resources extraction and/or primary material-making as their major industries constitute the "ecologically black band", whose ecological deficits ranged from 2.45 to 5.23 ha/cap, the highest of all cities in the province. Fossil energy consumption was the major source of footprint amounting to 1.63 ha/cap at the provincial level, taking up 67.3% of the total. For cropland, modest ecological surpluses occurred in Jinzhou, Tieling, Huludao, and Panjin while modest ecological deficits in Dalian, Benxi, Fushun, and Dandong, resulting in an overall surplus for the province. Liaoning had a certain level of surplus in fishing ground (water area), mainly distributed in the coastal cities of Dalian, Panjin, Huludao, Yingkou, Jinzhou, and Dandong. Most cities had a small ecological deficit in pasture and all had a small ecological surplus in forest. The eco-efficiency, expressed as GDP value per hectare of footprint, exhibits high variations among the cities, with the highest (Shenyang) more than 10 times the lowest (Fuxin). Cities with manufacture, high-tech, and better developed service industries had high eco-efficiency, while those with resources extraction, primary material-making, and less developed service industries had low eco-efficiency. Based on the components and geographical distribution of ecological footprint, strategic policy implications are outlined for Liaoning’s development toward a sustainable future.

Comparative Analysis on Eco-Efficiency of Arable Land Ecological Footprint in Hubei

This paper uses the ecological footprint model to make comparison of the eco-efficiency of arable land ecological footprint in different years in Hubei Province, and makes comparison of that in Hubei and some countries. The results indicate that, since 1965, the eco-efficiency of arable land ecological footprint in Hubei has been improved year by year. However, the efficiency of arable land ecological footprint, compared with some other areas in the world, is much lower. In 1965, average eco-efficiency of world arable land ecological footprint is 3 421 US dollar/hm^2 while that of Hubei Province is 134 US dollar/hm^2, about 1/26 of the world＇s average level. The eco-efficiency of arable land ecological footprint for 2003 in Hubei Province, however, has become about 1/9 of the world＇s average level for the same year. Finally the author puts forward the ways to raise the eco-efficiency of arable land ecological footprint.

Risk assessment of the emergency processes： Healthcare failure mode and effect analysis

BACKGROUND: Ensuring about the patient's safety is the f irst vital step in improving the quality of care and the emergency ward is known as a high-risk area in treatment health care. The present study was conducted to evaluate the selected risk processes of emergency surgery department of a treatment-educational Qaem center in Mashhad by using analysis method of the conditions and failure effects in health care.METHODS: In this study, in combination(qualitative action research and quantitative crosssectional), failure modes and effects of 5 high-risk procedures of the emergency surgery department were identified and analyzed according to Healthcare Failure Mode and Effects Analysis(HFMEA). To classify the failure modes from the "nursing errors in clinical management model(NECM)", the classification of the effective causes of error from "Eindhoven model" and determination of the strategies to improve from the "theory of solving problem by an inventive method" were used. To analyze the quantitative data of descriptive statistics(total points) and to analyze the qualitative data, content analysis and agreement of comments of the members were used.RESULTS: In 5 selected processes by "voting method using rating", 23 steps, 61 sub-processes and 217 potential failure modes were identifi ed by HFMEA. 25(11.5%) failure modes as the high risk errors were detected and transferred to the decision tree. The most and the least failure modes were placed in the categories of care errors(54.7%) and knowledge and skill(9.5%), respectively. Also, 29.4% of preventive measures were in the category of human resource management strategy.CONCLUSION: "Revision and re-engineering of processes", "continuous monitoring of the works", "preparation and revision of operating procedures and policies", "developing the criteria for evaluating the performance of the personnel", "designing a suitable educational content for needs of employee", "training patients", "reducing the workload and power shortage", "improving team communication" and "preventive management of equipment's" were on the agenda as the guidelines.

Influence of social capital on the livelihood strategies of farmers under China's rural revitalization strategy in poor mountain areas: A case study of the Liangshan Yi autonomous prefecture

Social capital in the form of social resources or social networks is one of the most important livelihood capital of farmers, which can increase the labor productivity of poor households and increase income. It is important to explore the reasons underlying the livelihood strategy choices of farmers from the perspective of social capital under China’s rural revitalization strategy. In this study, the Liangshan Yi Autonomous Prefecture, a povertystricken mountainous area in southwestern China, was selected as the case study area, and multivariable linear regression models were constructed to analyze the influence of social capital on livelihood strategies.The results are as follows:(1) Individual social capital had a positive effect on non-agricultural livelihood strategies. On average, with a one-unit increase in individual social capital, the ratio of farmers’ nonagricultural income to total productive income(Income_Rto) increased by 0.002% and 0.062%,respectively. Collective social capital, with the Peasant Economic Cooperation Organization(PECO) as the carrier, had a negative effect on the non-agricultural livelihood strategies of farmers;on average, with a oneunit increase in PECO, Income_Rto decreased by approximately 0.053%. However, this effect was only significant in the river valley area.(2) The income differences among the different livelihood strategy types were explained by the livelihood strategy choices of farmers. As non-agricultural work can bring more benefits, the labor force exhibited one-way migration from villages to cities, resulting in a lack of the subject of rural revitalization. It is necessary to implement effective measures to highlight the role of PECO in increasing agricultural income for farmers. Finally,based on the above conclusions,policy recommendations with respect to livelihood transformation of farmers and rural sustainable development are discussed.

Numerical modeling and assessment of natural gas pipeline separation in China: the data from Henan Province

China’s natural gas market is focusing on price reform and aims to reconstruct vertically integrated industrial chains in the future.Based on the mixed complementarity problem model of gas markets with nodes in Henan Province,China,as an example,this paper applies numerical modeling to simulate the effects of social welfare and equilibrium prices on nodes in two scenarios:pipeline integration and pipeline separation.The findings reveal the following:(1)Pipeline separation yields greater overall social welfare than pipeline integration,with the welfare shifting from gas producers to consumption markets.(2)Pipeline separation lowers the equilibrium consumption prices by driving competition among gas supply sources.(3)Pipeline separation will increase the contribution of natural gas to primary energy.

Threshold effects of renewable energy consumption on economic growth under energy transformation

China proposed that non-fossil energy consumption account for 20% in total energy consumption. EU increased the target of renewable energy consumption share from 27% to 35% in 2030.Energy transformation and increasing renewable energy consumption are important energy strategies for all countries at present. Then, is the impact of renewable energy consumption on economic growth positive or negative? Are there any differences in the direction or magnitude of the impact among countries or regions, and what are the determinants behind them? We apply panel threshold effect model to test threshold effects of renewable energy consumption on economic growth of EU. Empirical result shows: first, the impact of renewable energy consumption on economic growth is negative. Second, renewable energy consumption has significant threshold effects on economic growth. Third, now, energy consumption intensity and GDP per capita of most EU members are in the appropriate threshold regimes. In contrast, more and more EU members are in the high-subsidy group. Fourth, the average annual growth rates of renewable energy consumption showed no significant difference between high-subsidy and lowsubsidy countries from 1990 to 2014. Therefore, subsidy with high economic cost is not the onlyeffective means to increase renewable energy consumption.