Background： The effectiveness of the combination of electroacupuncture （EA） and behavioral training （BT） for mid/advanced cerebral infarction （M/ACI） and related mechanisms remains unclear. This study aimed to ...Background： The effectiveness of the combination of electroacupuncture （EA） and behavioral training （BT） for mid/advanced cerebral infarction （M/ACI） and related mechanisms remains unclear. This study aimed to investigate the combined effects on the learning-memory ability and event-related potential P300 in rats with M/ACI. Methods： Eighty rats with M/ACI were divided into Group Model （M）, Group EA, Group BT, and Group EA-BT （n = 20） according to the random number with five healthy rats in Group Control （CON）. On the 6th week after modeling, EA, BT, and EA-BT were given to Group EA, Group BT, and Group EA-BT, respectively, whereas Group M and Group CON were not given any intervention. Y-maze test and P300 were recorded before and after the intervention. Results： After intervention, the P300 latency was lower and the amplitude was higher in the Group EA-BT, Group EA, and Group BT than before （for latency, t = -7.638, -4.334, and -5.916; for amplitude, t = 8.125, 3.846, and 5.238; P 〈 0.01 ）, with Group EA-BT superior to Group EA （for latency, t = -3.708; for amplitude, t = 3.653; P 〈 0.01） and Group BT （for latency, t = -2.067; for amplitude, t = 2.816; P 〈 0.05）, with no significant difference between Group BT and EA （for latency, t = -1.439; for amplitude, t = 1.075; P 〉 0.05）. While the performances of Y-maze tests in the Group EA-BT, Group EA, and Group BT were all better than before （t = 10.359, 4.520, and 7.791, P 〈 0.01）, with Group EA-BT better than Group EA （t = 5.627, P 〈 0.01 ） and Group BT （t = 2.913, P 〈 0.01 ） respectively, and Group BT better than Group EA （t = 2.912, P 〈 0.01）. Conclusion： EA or BT can affect P300 in rats with M/ACI, and the combination of these two methods can significantly improve the learning-memory ability.展开更多
文摘Background： The effectiveness of the combination of electroacupuncture （EA） and behavioral training （BT） for mid/advanced cerebral infarction （M/ACI） and related mechanisms remains unclear. This study aimed to investigate the combined effects on the learning-memory ability and event-related potential P300 in rats with M/ACI. Methods： Eighty rats with M/ACI were divided into Group Model （M）, Group EA, Group BT, and Group EA-BT （n = 20） according to the random number with five healthy rats in Group Control （CON）. On the 6th week after modeling, EA, BT, and EA-BT were given to Group EA, Group BT, and Group EA-BT, respectively, whereas Group M and Group CON were not given any intervention. Y-maze test and P300 were recorded before and after the intervention. Results： After intervention, the P300 latency was lower and the amplitude was higher in the Group EA-BT, Group EA, and Group BT than before （for latency, t = -7.638, -4.334, and -5.916; for amplitude, t = 8.125, 3.846, and 5.238; P 〈 0.01 ）, with Group EA-BT superior to Group EA （for latency, t = -3.708; for amplitude, t = 3.653; P 〈 0.01） and Group BT （for latency, t = -2.067; for amplitude, t = 2.816; P 〈 0.05）, with no significant difference between Group BT and EA （for latency, t = -1.439; for amplitude, t = 1.075; P 〉 0.05）. While the performances of Y-maze tests in the Group EA-BT, Group EA, and Group BT were all better than before （t = 10.359, 4.520, and 7.791, P 〈 0.01）, with Group EA-BT better than Group EA （t = 5.627, P 〈 0.01 ） and Group BT （t = 2.913, P 〈 0.01 ） respectively, and Group BT better than Group EA （t = 2.912, P 〈 0.01）. Conclusion： EA or BT can affect P300 in rats with M/ACI, and the combination of these two methods can significantly improve the learning-memory ability.
