In this paper, a novel empirical equation is proposed to calculate the relative permeability of low permeability reservoir. An improved item is introduced on the basis of Rose empirical formula and Al-Fattah empirical...In this paper, a novel empirical equation is proposed to calculate the relative permeability of low permeability reservoir. An improved item is introduced on the basis of Rose empirical formula and Al-Fattah empirical formula, with one simple model to describe oil/water relative permeability. The position displacement idea of bare bones particle swarm optimization is applied to change the mutation operator to improve the RNA genetic algorithm. The parameters of the new empirical equation are optimized with the hybrid RNA genetic algorithm(HRGA) based on the experimental data. The data is obtained from a typical low permeability reservoir well 54 core 27-1 in Gu Dong by unsteady method. We carry out matlab programming simulation with HRGA. The comparison and error analysis show that the empirical equation proposed is more accurate than the Rose empirical formula and the exponential model. The generalization of the empirical equation is also verified.展开更多
We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice ...We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma.展开更多
基金Supported by the National Natural Science Foundation of China(60974039)the Natural Science Foundation of Shandong Province(ZR2011FM002)
文摘In this paper, a novel empirical equation is proposed to calculate the relative permeability of low permeability reservoir. An improved item is introduced on the basis of Rose empirical formula and Al-Fattah empirical formula, with one simple model to describe oil/water relative permeability. The position displacement idea of bare bones particle swarm optimization is applied to change the mutation operator to improve the RNA genetic algorithm. The parameters of the new empirical equation are optimized with the hybrid RNA genetic algorithm(HRGA) based on the experimental data. The data is obtained from a typical low permeability reservoir well 54 core 27-1 in Gu Dong by unsteady method. We carry out matlab programming simulation with HRGA. The comparison and error analysis show that the empirical equation proposed is more accurate than the Rose empirical formula and the exponential model. The generalization of the empirical equation is also verified.
基金supported by a Direct Grant for Research 2021/2022(Medicine Panel),project code:2020.011,The Chinese University of Hong Kong,Hong Kong,China.The funders of the study had no involvement in the study design,data collection,data analysis,interpretation,writing of the report,or decision to submit the paper for publication.
文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma.
