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Energy Efficiency, Indoor Air Quality and Thermal Comfort Studies at the Faculty of Engineering and Built Environment, University Kebangsaan Malaysia
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作者 N.L. Teng S.M. Zain +1 位作者 N.E.A. Basri S. Mat 《Journal of Environmental Science and Engineering》 2011年第11期1407-1413,共7页
The study was conducted to identify indoor air quality and the level of thermal comfort in various selected locations in Faculty of Engineering and Built Environment (FKAB), University Kebangsaan Malaysia (UKM) wi... The study was conducted to identify indoor air quality and the level of thermal comfort in various selected locations in Faculty of Engineering and Built Environment (FKAB), University Kebangsaan Malaysia (UKM) with built-up area of 250,936 fie. The indoor air quality and thermal comfort were measured at various selected locations by using indoor air quality equipment (Thermal Comfort SERI). The thermal comfort assessments are based on Malaysian Code of Practice Indoor Air Quality 2005 and Moderate Thermal Environments-Determination of the PMV and PPD indices specification of the condition for thermal comfort (ISO7730:1994) From the data analysis, the FKAB building is considered inadequately vented space. The concentration of CO2 for all sampling area evaluated exceeds the recommended concentration (〉 1000 ppm). The ventilation system used in FKAB building is designed by delivering fix amount of fresh air into building from external building without consideration on the number of occupants. This common ventilation design will increase the amount of CO2 dramatically all day long and these reflect the inefficiency of energy used. The faculty needs to be equipped with a comprehensive energy management system that can allow detailed documentation of continuous performance of all energy system and consumption in the building. 展开更多
关键词 Energy efficiency indoor air quality comfort survey FKAB UKM
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In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds
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作者 Yanhao Hou Weiguang Wang Paulo Bartolo 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第5期651-669,共19页
Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field.Due to the intrinsic limitations of PCL,carbon nanomateria... Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field.Due to the intrinsic limitations of PCL,carbon nanomaterials are often investigated to reinforce the PCL scaffolds.Despite several studies that have been conducted on carbon nanomaterials,such as graphene(G)and graphene oxide(GO),certain challenges remain in terms of the precise design of the biological and nonbiological properties of the scaffolds.This paper addresses this limitation by investigating both the nonbiological(element composition,surface,degradation,and thermal and mechanical properties)and biological characteristics of carbon nanomaterial-reinforced PCL scaffolds for bone tissue engineering applications.Results showed that the incorporation of G and GO increased surface properties(reduced modulus and wettability),material crystallinity,crystallization temperature,and degradation rate.However,the variations in compressive modulus,strength,surface hardness,and cell metabolic activity strongly depended on the type of reinforcement.Finally,a series of phenomenological models were developed based on experimental results to describe the variations of scaffold’s weight,fiber diameter,porosity,and mechanical properties as functions of degradation time and carbon nanomaterial concentrations.The results presented in this paper enable the design of three-dimensional(3D)bone scaffolds with tuned properties by adjusting the type and concentration of different functional fillers. 展开更多
关键词 Additive manufacturing Bone tissue engineering Carbon nanomaterial GRAPHENE Graphene oxide SCAFFOLD
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Predicting Rock Burst in Underground Engineering Leveraging a Novel Metaheuristic-Based LightGBM Model
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作者 Kai Wang Biao He +1 位作者 Pijush Samui Jian Zhou 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期229-253,共25页
Rock bursts represent a formidable challenge in underground engineering,posing substantial risks to both infrastructure and human safety.These sudden and violent failures of rock masses are characterized by the rapid ... Rock bursts represent a formidable challenge in underground engineering,posing substantial risks to both infrastructure and human safety.These sudden and violent failures of rock masses are characterized by the rapid release of accumulated stress within the rock,leading to severe seismic events and structural damage.Therefore,the development of reliable prediction models for rock bursts is paramount to mitigating these hazards.This study aims to propose a tree-based model—a Light Gradient Boosting Machine(LightGBM)—to predict the intensity of rock bursts in underground engineering.322 actual rock burst cases are collected to constitute an exhaustive rock burst dataset,which serves to train the LightGBMmodel.Two population-basedmetaheuristic algorithms are used to optimize the hyperparameters of the LightGBM model.Finally,the sensitivity analysis is used to identify the predominant factors that may incur the occurrence of rock bursts.The results show that the population-based metaheuristic algorithms have a good ability to search out the optimal hyperparameters of the LightGBM model.The developed LightGBM model yields promising performance in predicting the intensity of rock bursts,with which accuracy on training and testing sets are 0.972 and 0.944,respectively.The sensitivity analysis discloses that the risk of occurring rock burst is significantly sensitive to three factors:uniaxial compressive strength(σc),stress concentration factor(SCF),and elastic strain energy index(Wet).Moreover,this study clarifies the particular impact of these three factors on the intensity of rock bursts through the partial dependence plot. 展开更多
关键词 Rock burst prediction LightGBM coati optimization algorithm pelican optimization algorithm partial dependence plot
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Development and optimization of object detection technology in pavement engineering: A literature review
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作者 Hui Yao Yaning Fan +7 位作者 Yanhao Liu Dandan Cao Ning Chen Tiancheng Luo Jingyu Yang Xueyi Hu Jie Ji Zhanping You 《Journal of Road Engineering》 2024年第2期163-188,共26页
Due to the rapid advancement of the transportation industry and the continual increase in pavement infrastructure,it is difficult to keep up with the huge road maintenance task by relying only on the traditional manua... Due to the rapid advancement of the transportation industry and the continual increase in pavement infrastructure,it is difficult to keep up with the huge road maintenance task by relying only on the traditional manual detection method.Intelligent pavement detection technology with deep learning techniques is available for the research and industry areas by the gradual development of computer vision technology.Due to the different characteristics of pavement distress and the uncertainty of the external environment,this kind of object detection technology for distress classification and location still faces great challenges.This paper discusses the development of object detection technology and analyzes classical convolutional neural network(CNN)architecture.In addition to the one-stage and two-stage object detection frameworks,object detection without anchor frames is introduced,which is divided according to whether the anchor box is used or not.This paper also introduces attention mechanisms based on convolutional neural networks and emphasizes the performance of these mechanisms to further enhance the accuracy of object recognition.Lightweight network architecture is introduced for mobile and industrial deployment.Since stereo cameras and sensors are rapidly developed,a detailed summary of three-dimensional object detection algorithms is also provided.While reviewing the history of the development of object detection,the scope of this review is not only limited to the area of pavement crack detection but also guidance for researchers in related fields is shared. 展开更多
关键词 Pavement engineering Object detection Lightweight network Attention mechanism Convolutional neural network
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Building Custom Spreadsheet Functions with Python: End-User Software Engineering Approach
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作者 Tamer Bahgat Elserwy Atef Tayh Nour El-Din Raslan +1 位作者 Tarek Ali Mervat H. Gheith 《Journal of Software Engineering and Applications》 2024年第5期246-258,共13页
End-user computing empowers non-developers to manage data and applications, enhancing collaboration and efficiency. Spreadsheets, a prime example of end-user programming environments widely used in business for data a... End-user computing empowers non-developers to manage data and applications, enhancing collaboration and efficiency. Spreadsheets, a prime example of end-user programming environments widely used in business for data analysis. However, Excel functionalities have limits compared to dedicated programming languages. This paper addresses this gap by proposing a prototype for integrating Python’s capabilities into Excel through on-premises desktop to build custom spreadsheet functions with Python. This approach overcomes potential latency issues associated with cloud-based solutions. This prototype utilizes Excel-DNA and IronPython. Excel-DNA allows creating custom Python functions that seamlessly integrate with Excel’s calculation engine. IronPython enables the execution of these Python (CSFs) directly within Excel. C# and VSTO add-ins form the core components, facilitating communication between Python and Excel. This approach empowers users with a potentially open-ended set of Python (CSFs) for tasks like mathematical calculations, statistical analysis, and even predictive modeling, all within the familiar Excel interface. This prototype demonstrates smooth integration, allowing users to call Python (CSFs) just like standard Excel functions. This research contributes to enhancing spreadsheet capabilities for end-user programmers by leveraging Python’s power within Excel. Future research could explore expanding data analysis capabilities by expanding the (CSFs) functions for complex calculations, statistical analysis, data manipulation, and even external library integration. The possibility of integrating machine learning models through the (CSFs) functions within the familiar Excel environment. 展开更多
关键词 End-User Software Engineering Custom Spreadsheet Functions (CSFs)
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Hydrogen Energy Storage System:Review on Recent Progress
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作者 MilleniumWong Hadi Nabipour Afrouzi 《Energy Engineering》 EI 2025年第1期1-39,共39页
A hydrogen energy storage system(HESS)is one of the many risingmodern green innovations,using excess energy to generate hydrogen and storing it for various purposes.With that,there have been many discussions about com... A hydrogen energy storage system(HESS)is one of the many risingmodern green innovations,using excess energy to generate hydrogen and storing it for various purposes.With that,there have been many discussions about commercializing HESS and improving it further.However,the design and sizing process can be overwhelming to comprehend with various sources to examine,and understanding optimal design methodologies is crucial to optimize a HESS design.With that,this review aims to collect and analyse a wide range of HESS studies to summarise recent studies.Two different collections of studies are studied,one was sourced by the main author for preliminary readings,and another was obtained via VOSViewer.The findings from the Web of Science platform were also examined for amore comprehensive understanding.Major findings include the People’sRepublic of China has been active in HESS research,as most works and active organizations originate from this country.HESS has been mainly researched to support power generation and balance load demands,with financial analysis being the common scope of analysis.MATLAB is a common tool used for HESS design,modelling,and optimization as it can handle complex calculations.Artificial neural network(ANN)has the potential to be used to model the HESS,but additional review is required as a formof future work.From a commercialization perspective,pressurized hydrogen tanks are ideal for hydrogen storage in a HESS,but other methods can be considered after additional research and development.From this review,it can be implied that modelling works will be the way forward for HESS research,but extensive collaborations and additional review are needed.Overall,this review summarized various takeaways that future research works on HESS can use. 展开更多
关键词 Hydrogen energy storage system VOSViewer DESIGN REVIEW SIZING
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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair
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作者 Simeon C.Daeschler Katelyn J.W.So +7 位作者 Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel 《Neural Regeneration Research》 SCIE CAS 2025年第1期291-304,共14页
Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies a... Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies available to promote nerve regeneration.Tacrolimus accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve surgery.The authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug exposure.Tacrolimus is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 days.Size and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible byproducts.Tacrolimus released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic delivery.Given its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery. 展开更多
关键词 BIODEGRADABLE local drug delivery nerve injury nerve regeneration nerve wrap TACROLIMUS
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Market Drivers in India’s Smart Grid:Responsibilities and Roles of Stakeholders
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作者 Abhay Sanatan Satapathy Suresh Kumar Sahoo +3 位作者 Asit Mohanty Yasser Fouad Manzoore ElahiMohammad Soudagar Erdem Cuce 《Energy Engineering》 EI 2025年第1期101-128,共28页
The emergence of smart grids in India is propelled by an intricate interaction of market dynamics,regulatory structures,and stakeholder obligations.This study analyzes the primary factors that are driving the widespre... The emergence of smart grids in India is propelled by an intricate interaction of market dynamics,regulatory structures,and stakeholder obligations.This study analyzes the primary factors that are driving the widespread use of smart grid technologies and outlines the specific roles and obligations of different stakeholders,such as government entities,utility companies,technology suppliers,and consumers.Government activities and regulations are crucial in facilitating the implementation of smart grid technology by offering financial incentives,regulatory assistance,and strategic guidance.Utility firms have the responsibility of implementing and integrating smart grid infrastructure,with an emphasis on improving the dependability of the grid,minimizing losses in transmission and distribution,and integrating renewable energy sources.Technology companies offer the essential hardware and software solutions,which stimulate creativity and enhance efficiency.Consumers actively engage in the energy ecosystem by participating in demand response,implementing energy saving measures,and adopting distributed energy resources like solar panels and electric vehicles.This study examines the difficulties and possibilities in India’s smart grid industry,highlighting the importance of cooperation among stakeholders to build a strong,effective,and environmentally friendly energy future. 展开更多
关键词 Smart grid STAKEHOLDERS smart grid technology market drivers
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Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization
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作者 Ziquan Wang Xiangfeng Chen +5 位作者 Yuan Zhang Jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期1-17,共17页
Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of waters.However,it still suffers from inefficient charge transfer... Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of waters.However,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current collectors.Herein,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport significantly.The effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal resistance.With the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current collectors.Meanwhile,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current collectors.Additionally,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability. 展开更多
关键词 Flow-electrode Capacitive deionization Current collector Tip effect DESALINATION
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Ontology Engineering and Knowledge Services for Agriculture Domain 被引量:12
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作者 Asanee Kawtrakul 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2012年第5期741-751,共11页
This paper presents a knowledge service system for the domain of agriculture. Three key issues for providing knowledge services are how to improve the access of unstructured and scattered information for the non-speci... This paper presents a knowledge service system for the domain of agriculture. Three key issues for providing knowledge services are how to improve the access of unstructured and scattered information for the non-specialist users, how to provide adequate information to knowledge workers and how to provide the information requiring highly focused and related information. Cyber-Brain has been designed as a platform that combines approaches based on knowledge engineering and language engineering to gather knowledge from various sources and to provide the effective knowledge service. Based on specially designed ontology for practical service scenarios, it can aggregate knowledge from Internet, digital archives, expert, and other resources for providing one-stop-shop knowledge services. The domain specific and task oriented ontology also enables advanced search and allows the system ensures that knowledge service could improve the user benefit. Users are presented with the necessary information closely related to their information need and thus of potential high interest. This paper presents several service scenarios for different end-users and reviews ontology engineering and its life cycle for supporting AOS (Agricultural Ontology Services) Vocbench which is the heart of knowledge services in agriculture domain. 展开更多
关键词 knowledge service ontology construction ontology design ontology maintenance natural languageprocessing ontology based knowledge services
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Biological process of soil improvement in civil engineering:A review 被引量:16
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作者 Murtala Umar Khairul Anuar Kassim Kenny Tiong Ping Chiet 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2016年第5期767-774,共8页
The concept of using biological process in soil improvement which is known as bio-mediated soil improvement technique has shown greater potential in geotechnical engineering applications in terms of performance and en... The concept of using biological process in soil improvement which is known as bio-mediated soil improvement technique has shown greater potential in geotechnical engineering applications in terms of performance and environmental sustainability. This paper presents a review on the soil microorganisms responsible for this process, and factors that affect their metabolic activities and geometric compatibility with the soil particle sizes. Two mechanisms of biomineralization, i.e. biologically controlled and biologically induced mineralization, were also discussed. Environmental and other factors that may be encountered in situ during microbially induced calcite precipitation (MICP) and their influences on the process were identified and presented. Improvements in the engineering properties of soil such as strength/stiffness and permeability as evaluated in some studies were explored. Potential applications of the process in geotechnical engineering and the challenges of field application of the process were identified. 展开更多
关键词 Bio-mediated soil improvement Microorganisms Metabolic activities BiomineralizationUrease activity
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Study on the optical property and biocompatibility of a tissue engineering cornea 被引量:3
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作者 Yukiko Nakahara Dwight Xuan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2012年第1期45-49,共5页
AIM: To study the optical property and biocompatibility of a tissue engineering cornea. METHODS: The cross-linker of N- (3-Dimethylaminoropyl)-N'ethylcarbodiimide hydrochloride (EDC)/ N-Hydroxysuccinimide (NHS) wa... AIM: To study the optical property and biocompatibility of a tissue engineering cornea. METHODS: The cross-linker of N- (3-Dimethylaminoropyl)-N'ethylcarbodiimide hydrochloride (EDC)/ N-Hydroxysuccinimide (NHS) was mixed with Type I collagen at 10% (weight/volume). The final solution was molded to the shape of a corneal contact lens. The collagen concentrations of 10%, 12.5%, 15%, 17.5% and 20% artificial corneas were tested by UV/vis-spectroscopy for their transparency compared with normal rat cornea. 10-0 sutures were knotted on the edges of substitute to measure the corneal buttons's mechanical properties. Normal rat corneal tissue primary culture on the collagen scaffold was observed in 4 weeks. Histopathologic examinations were performed after 4 weeks of in vitro culturing. RESULTS: The collagen scaffold appearance was similar to that of soft contact lens. With the increase of collagen concentration, the transparency of artificial corneal buttons was diminished, but the toughness of the scaffold was enhanced. The scaffold transparency in the 10% concentration collagen group resembled normal rat cornea. To knot and embed the scaffold under the microscope, 20% concentration collagen group was more effective during implantation than lower concentrations of collagen group. In the first 3 weeks, corneal cell proliferation was highly active. The shapes of cells that grew on the substitute had no significant difference when compared with the cells before they were moved to the scaffold. However, on the fortieth day, most cells detached from the scaffold and died. Histopathologic examination of the primary culture scaffold revealed well grown corneal cells tightly attached to the scaffold in the former culturing. CONCLUSION: Collagen scaffold can be molded to the shape of soft contact corneal lens with NHS/EDC. The biological stability and biocompatibility of collagen from animal species may be used as material in preparing to engineer artificial corneal scaffold. 展开更多
关键词 tissue engineering collagen cross-linking scaffold primary culture in vitro optical property BIOCOMPATIBILITY
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Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells 被引量:3
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作者 Jelena G Najdanović Vladimir J Cvetković +3 位作者 Sanja T Stojanović MarijaĐVukelić-Nikolić Jelena MŽivković Stevo J Najman 《World Journal of Stem Cells》 SCIE CAS 2021年第1期91-114,共24页
BACKGROUND A major problem in the healing of bone defects is insufficient or absent blood supply within the defect.To overcome this challenging problem,a plethora of approaches within bone tissue engineering have been... BACKGROUND A major problem in the healing of bone defects is insufficient or absent blood supply within the defect.To overcome this challenging problem,a plethora of approaches within bone tissue engineering have been developed recently.Bearing in mind that the interplay of various diffusible factors released by endothelial cells(ECs)and osteoblasts(OBs)have a pivotal role in bone growth and regeneration and that adjacent ECs and OBs also communicate directly through gap junctions,we set the focus on the simultaneous application of these cell types together with platelet-rich plasma(PRP)as a growth factor reservoir within ectopic bone tissue engineering constructs.AIM To vascularize and examine osteogenesis in bone tissue engineering constructs enriched with PRP and adipose-derived stem cells(ASCs)induced into ECs and OBs.METHODS ASCs isolated from adipose tissue,induced in vitro into ECs,OBs or just expanded were used for implant construction as followed:BPEO,endothelial and osteogenic differentiated ASCs with PRP and bone mineral matrix;BPUI,uninduced ASCs with PRP and bone mineral matrix;BC(control),only bone mineral matrix.At 1,2,4 and 8 wk after subcutaneous implantation in mice,implants were extracted and endothelial-related and bone-related gene expression were analyzed,while histological analyses were performed after 2 and 8 wk.RESULTS The percentage of vascularization was significantly higher in BC compared to BPUI and BPEO constructs 2 and 8 wk after implantation.BC had the lowest endothelial-related gene expression,weaker osteocalcin immunoexpression and Spp1 expression compared to BPUI and BPEO.Endothelial-related gene expression and osteocalcin immunoexpression were higher in BPUI compared to BC and BPEO.BPEO had a higher percentage of vascularization compared to BPUI and the highest CD31 immunoexpression among examined constructs.Except Vwf,endothelial-related gene expression in BPEO had a later onset and was upregulated and well-balanced during in vivo incubation that induced late onset of Spp1 expression and pronounced osteocalcin immunoexpression at 2 and 8 wk.Tissue regression was noticed in BPEO constructs after 8 wk.CONCLUSION Ectopically implanted BPEO constructs had a favorable impact on vascularization and osteogenesis,but tissue regression imposed the need for discovering a more optimal EC/OB ratio prior to considerations for clinical applications. 展开更多
关键词 Adipose-derived stem cells Endothelial-related genes Bone-related genes Ectopic osteogenesis VASCULARIZATION Platelet-rich plasma
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Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment 被引量:2
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作者 Nathalie Bock Ali Shokoohmand +6 位作者 Thomas Kryza Joan Rohl Jonelle Meijer Phong A. Tran Colleen C. Nelson Judith A. Clements Dietmar W. Hutmacher 《Bone Research》 SCIE CAS CSCD 2019年第2期157-170,共14页
While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood.Here,we tissue-engineered and... While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood.Here,we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases,and used it to study the effects of androgen deprivation in this microenvironment.The model was established by culturing primary human osteoprogenitor cells on melt electrowritten polymer scaffolds,leading to a mineralized osteoblast-derived microtissue containing,in a 3D setting,viable osteoblastic cells,osteocytic cells,and appropriate expression of osteoblast/osteocyte-derived mRNA and proteins,and mineral content.Direct co-culture of androgen receptordependent/ independent cell lines (LNCaP,C4-2B,and PC3) led cancer cells to display functional and molecular features as observed in vivo.Co-cultured cancer cells showed increased affinity to the microtissues,as a function of their bone metastatic potential.Cocultures led to alkaline phosphatase and collagen-I upregulation and sclerostin downregulation,consistent with the clinical marker profile of osteoblastic bone metastases.LNCaP showed a significant adaptive response under androgen deprivation in the microtissues,with the notable appearance of neuroendocrine transdifferentiation features and increased expression of related markers (dopa decarboxylase,enolase 2).Androgen deprivation affected the biology of the metastatic microenvironment with stronger upregulation of androgen receptor,alkaline phosphatase,and dopa decarboxylase,as seen in the transition towards resistance.The unique microtissues engineered here represent a substantial asset to determine the involvement of the human bone microenvironment in prostate cancer progression and response to a therapeutic context in this microenvironment. 展开更多
关键词 ENGINEERING OSTEOBLASTIC METASTASES the adaptive response METASTATIC MICROENVIRONMENT
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Application of Radial Basis Function Learning Algorithm in Petroleum Engineering: Bottom-Hole Pressure Prediction 被引量:1
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作者 Mehdi Mohammadpoor Farshid Torabi 《材料科学与工程(中英文A版)》 2011年第4X期586-591,共6页
关键词 径向基函数神经网络 压力预测 石油工程 井底压力 学习算法 垂直多相流 RBFNN 应用
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Reversible Magnesium Metal Anode Enabled by Cooperative Solvation/Surface Engineering in Carbonate Electrolytes 被引量:2
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作者 Caiyun Wang Yao Huang +5 位作者 Yunhao Lu Hongge Pan Ben Bin Xu Wenping Sun Mi Yan Yinzhu Jiang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第12期109-119,共11页
Magnesium metal anode holds great potentials toward future high energy and safe rechargeable magnesium battery technology due to its divalent redox and dendrite-free nature. Electrolytes based on Lewis acid chemistry ... Magnesium metal anode holds great potentials toward future high energy and safe rechargeable magnesium battery technology due to its divalent redox and dendrite-free nature. Electrolytes based on Lewis acid chemistry enable the reversible Mg plating/stripping,while they fail to match most cathode materials toward highvoltage magnesium batteries. Herein,reversible Mg plating/stripping is achieved in conventional carbonate electrolytes enabled by the cooperative solvation/surface engineering. Strongly electronegative Cl from the MgCl_(2) additive of electrolyte impairs the Mg…O = C interaction to reduce the Mg^(2+) desolvation barrier for accelerated redox kinetics,while the Mg^(2+)-conducting polymer coating on the Mg surface ensures the facile Mg^(2+) migration and the e ective isolation of electrolytes. As a result,reversible plating and stripping of Mg is demonstrated with a low overpotential of 0.7 V up to 2000 cycles. Moreover,benefitting from the wide electrochemical window of carbonate electrolytes,high-voltage(> 2.0 V) rechargeable magnesium batteries are achieved through assembling the electrode couple of Mg metal anode and Prussian blue-based cathodes. The present work provides a cooperative engineering strategy to promote the application of magnesium anode in carbonate electrolytes toward high energy rechargeable batteries. 展开更多
关键词 Rechargeable magnesium batteries Metal anode Solvation effect PASSIVATION Carbonate electrolytes
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An Optimum and Effective Drawing Teaching System in Engineering 被引量:1
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作者 Rsutu Ucan Hatice Ercan Sami Ercan 《Computer Technology and Application》 2012年第1期76-83,共8页
In this study, the authors shall illustrate the difficulties, pros and cons of "Technical Drawing" courses in engineering curriculums. The authors also show the efficiency, effectiveness of students' grasping the e... In this study, the authors shall illustrate the difficulties, pros and cons of "Technical Drawing" courses in engineering curriculums. The authors also show the efficiency, effectiveness of students' grasping the engineering drawing concepts in depth. The authors have conducted a survey on students and their instructors for teaching the course. Whether the course should be taught with manual handling and then computerized or starting with computer aid and finishing the content of the course, the authors shall also go in detail of syllabus how the drawing rooms and aid tools will be. This part of study shall look into the ergonomics, safety and conditions of classrooms. Responses of 300 students will be shared in this presentation. Statistical analysis will detect the effects of different factors involved in the questionnaire. 展开更多
关键词 CID (computer integrated drawing) efficiency.
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An engineering classification system for the detached granite blocks distributed on slopes
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作者 ZHAO Xiu-cheng ZHAO Xiao-yan +1 位作者 SHEN Wei-gang LUO Gang 《Journal of Mountain Science》 SCIE CSCD 2023年第2期516-531,共16页
Gentle slopes with large amounts of granite blocks are widespread in granitic areas with warm and humid climate.These blocks pose a potential risk to the existing and planned infrastructure.The instability type and ge... Gentle slopes with large amounts of granite blocks are widespread in granitic areas with warm and humid climate.These blocks pose a potential risk to the existing and planned infrastructure.The instability type and geometry of these blocks will influence their motility and destructive power to some extent.This study aims at creating a classification system that can indicate both the shape and the instability type of these blocks and then developing a block removal scheme.The classification system was constructed based on the mechanical stability analysis of blocks on an inclined surface.This analysis identified key factors affecting stability,including block shape,block weathering roundness,the existing state of a block on a slope,and the friction between the block and the slope.The achieved work allowed the establishment of a direct correlation between block geometry and their instability types.The availability of this classification system was validated by field data and experimental data in the literature.The proposal to remove blocks identified as the toppling types,such as cylindrical-toppling types,cuboid-toppling types,cube-toppling types,was put forward to avoid the uneconomical problem of a complete clearance.Meanwhile,this classification provides a foundation for further research on the instability probability of each type of block and the development of a more refined blocks’removal scheme.The classification approach adopted in this paper can provide a reference for the classification of other lithological blocks under similar engineering geological conditions. 展开更多
关键词 South China Granite blocks Classification system Geometry characteristics Instability type Existing state
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Application of ion-engineered Persian Gulf seawater in EOR:effects of different ions on interfacial tension,contact angle,zeta potential,and oil recovery
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作者 Amir Hossein Saeedi Dehaghani Seyed Masoud Ghalamizade Elyaderani 《Petroleum Science》 SCIE CAS CSCD 2021年第3期895-908,共14页
In this study,we initially performed interfacial tension(IFT)tests to investigate the potential of using the Persian Gulf seawater(PGSW)as smart water with diferent concentrations of NaCl,KCl,MgCl_(2),CaCl_(2),and Na_... In this study,we initially performed interfacial tension(IFT)tests to investigate the potential of using the Persian Gulf seawater(PGSW)as smart water with diferent concentrations of NaCl,KCl,MgCl_(2),CaCl_(2),and Na_(2)SO_(4).Next,for each salt,at the concentration where IFT was minimum,we conducted contact angle,zeta potential,and micromodel fooding tests.The results showed that IFT is minimized if NaCl or KCl is removed from PGSW;thus,for solutions lacking NaCl and KCl,the IFT values were obtained at 26.29 and 26.56 mN/m,respectively.Conversely,in the case of divalent ions,minimum IFT occurred when the concentration of MgCl_(2),CaCl_(2),and Na_(2)SO_(4) in PGSW increased.Specifcally,a threefold rise in the concentration of Na_(2)SO_(4) further reduced IFT as compared to optimal concentrations of MgCl_(2) or CaCl_(2).It should be mentioned that eliminating NaCl from PGSW resulted in the lowest IFT value compared to adding or removing other ions.Whereas the removal of NaCl caused the contact angle to decrease from 91.0°to 67.8°relative to PGSW and changed surface wettability to weakly water-wet,eliminating KCl did not considerably change the contact angle,such that it only led to a nine-degree reduction in this angle relative to PGSW and left wettability in the same neutral-wet condition.At optimal concentrations of MgCl_(2),CaCl_(2),and Na_(2)SO_(4),only an increase in Na_(2)SO_(4) concentration in PGSW could change wettability from neutral-wet to weakly water-wet.For solutions with optimal concentrations,the removal of NaCl or KCl caused the rock surface to have slightly higher negative charges,and increasing the concentration of divalent ions led to a small reduction in the negative charge of the surface.The results of micromodel fooding indicated that NaCl-free PGSW could raise oil recovery by 10.12%relative to PGSW.Furthermore,when the Na_(2)SO_(4) concentration in PGSW was tripled,the oil recovery increased by 7.34%compared to PGSW.Accordingly,depending on the conditions,it is possible to use PGSW so as to enhance the efciency of oil recovery by removing NaCl or by increasing the concentration of Na_(2)SO_(4) three times. 展开更多
关键词 Smart water Minimum IFT WETTABILITY Zeta potential Enhanced oil recovery
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黄河流域煤炭开发区地下水污染成因分析及防治建议 被引量:2
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作者 焦华喆 陈曦 +5 位作者 张铁岗 杨柳华 陈新明 HONAKER Rick 马俊伟 余洋 《中国地质》 CAS CSCD 北大核心 2024年第1期143-156,共14页
[研究目的]黄河流域内由于煤炭资源开发导致地下水污染严重,从整体角度对流域内重点煤炭开发区地下水进行归纳总结,为其可持续健康发展和地下水资源改善提供防治建议。[研究方法]从黄河流域战略地位出发,对地下水污染成因和污染模式进... [研究目的]黄河流域内由于煤炭资源开发导致地下水污染严重,从整体角度对流域内重点煤炭开发区地下水进行归纳总结,为其可持续健康发展和地下水资源改善提供防治建议。[研究方法]从黄河流域战略地位出发,对地下水污染成因和污染模式进行归纳总结。采用改进后的综合水质指数法对流域内九大煤炭基地的地下水进行水质评价。选用主成分分析法赋权指标,并引入改进的内梅罗污染指数法,按照WPI分级法进行评价。[研究结果]通过对黄河流域各重点断面水质评价,得到目前流域内煤炭基地水质结果中Ⅲ、Ⅳ类占比较多,水质较差。分析成因当前流域内存在高矿化度矿井水、酸性矿井水和含特殊组分矿井水污染,同时阐述污染地下水形成的浅层和深层两种污染模式。[结论]对3种矿井水采用相应防治方法,并提出膏体充填技术和微生物修复技术2种防治技术建议,通过应用实际矿山为例,印证污染防治技术能够改善由煤炭开采引发的流域内地下水污染严重的问题,以期研究结果能够对成功推动中国绿色矿山的快速发展具有参考意义。 展开更多
关键词 地下水 煤炭开采 水质评价 水文地质调查工程 矿产勘查工程 黄河流域
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