Alum has an excellent safety record and is the only licensed inorganic adjuvant for human vaccines.However,the exploration of alum nanosheets as chemotherapy drug delivery system,especially the clarification about the...Alum has an excellent safety record and is the only licensed inorganic adjuvant for human vaccines.However,the exploration of alum nanosheets as chemotherapy drug delivery system,especially the clarification about the relationship between structures and drug loading properties,is totally insufficient.Herein,aluminum hydroxides(AlOOH)nanosheets with tunable specific surface area and pore size were synthesized by adjusting the synthesis time in the presence of triblock copolymers.The obtained materials exhibited the highest surface area about 470 m2/g.The structure-dependent chemotherapy drug loading capability for AlOOH nanosheets was observed:the higher specific surface area and pore size are,the higher amount of chemotherapy drug is loaded.AlOOH nanosheets loaded with doxorubicin showed a pH-dependent sustained release behavior with quick release in low pH about 5 and slow release in pH around 7.4.Doxorubicin-loaded AlOOH nanosheets exhibited much higher cancer cellular uptake efficiency than that in free form by flow cytometry.Moreover,doxorubicin-loaded AlOOH nanosheets with high specific surface area showed an increased cellular uptake efficiency and enhanced ratios of apoptosis and necrosis,compared with those showing low specific surface area.Therefore,AlOOH nanosheets are promising materials as chemotherapy drug delivery system.展开更多
The aim of this paper is to investigate the effect of vehicle dynamics control systems （VDCS） on both the collision of the vehicle body and the kinematic behaviour of the ve- hicle＇s occupant in case of offset fron...The aim of this paper is to investigate the effect of vehicle dynamics control systems （VDCS） on both the collision of the vehicle body and the kinematic behaviour of the ve- hicle＇s occupant in case of offset frontal vehicle-to-vehicle collision. A unique 6-degree-of- freedom （6-DOF） vehicle dynamics/crash mathematical model and a simplified lumped mass occupant model are developed. The first model is used to define the vehicle body crash parameters and it integrates a vehicle dynamics model with a vehicle front-end structure model. The second model aims to predict the effect of VDCS on the kinematics of the occupant. It is shown from the numerical simulations that the vehicle dynamics/crash response and occupant behaviour can be captured and analysed quickly and accurately. Yurthermore, it is shown that the VDCS can affect the crash characteristics positively and the occupant behaviour is improved.展开更多
基金National Institute for Materials Science of Japan
文摘Alum has an excellent safety record and is the only licensed inorganic adjuvant for human vaccines.However,the exploration of alum nanosheets as chemotherapy drug delivery system,especially the clarification about the relationship between structures and drug loading properties,is totally insufficient.Herein,aluminum hydroxides(AlOOH)nanosheets with tunable specific surface area and pore size were synthesized by adjusting the synthesis time in the presence of triblock copolymers.The obtained materials exhibited the highest surface area about 470 m2/g.The structure-dependent chemotherapy drug loading capability for AlOOH nanosheets was observed:the higher specific surface area and pore size are,the higher amount of chemotherapy drug is loaded.AlOOH nanosheets loaded with doxorubicin showed a pH-dependent sustained release behavior with quick release in low pH about 5 and slow release in pH around 7.4.Doxorubicin-loaded AlOOH nanosheets exhibited much higher cancer cellular uptake efficiency than that in free form by flow cytometry.Moreover,doxorubicin-loaded AlOOH nanosheets with high specific surface area showed an increased cellular uptake efficiency and enhanced ratios of apoptosis and necrosis,compared with those showing low specific surface area.Therefore,AlOOH nanosheets are promising materials as chemotherapy drug delivery system.
基金the Egyptian government and the Faculty of Engineering,Ain Shams University for supporting this research
文摘The aim of this paper is to investigate the effect of vehicle dynamics control systems （VDCS） on both the collision of the vehicle body and the kinematic behaviour of the ve- hicle＇s occupant in case of offset frontal vehicle-to-vehicle collision. A unique 6-degree-of- freedom （6-DOF） vehicle dynamics/crash mathematical model and a simplified lumped mass occupant model are developed. The first model is used to define the vehicle body crash parameters and it integrates a vehicle dynamics model with a vehicle front-end structure model. The second model aims to predict the effect of VDCS on the kinematics of the occupant. It is shown from the numerical simulations that the vehicle dynamics/crash response and occupant behaviour can be captured and analysed quickly and accurately. Yurthermore, it is shown that the VDCS can affect the crash characteristics positively and the occupant behaviour is improved.
