Developing global partnerships is an important focus for China’s diplomacy in the new era.1 President Xi Jinping proposed at the Central Conference on Work Relating to Foreign Affairs in November 2014,“We should mak...Developing global partnerships is an important focus for China’s diplomacy in the new era.1 President Xi Jinping proposed at the Central Conference on Work Relating to Foreign Affairs in November 2014,“We should make more friends while abiding by the principle of non-alignment and build a global network of partnerships.”展开更多
A few years ago, after a vehement round of inner city renewal, I suddenly found many sidewalks in the city proper of Beijing became so narrow that pedestrians often had to compete with bikes and even automobiles for a...A few years ago, after a vehement round of inner city renewal, I suddenly found many sidewalks in the city proper of Beijing became so narrow that pedestrians often had to compete with bikes and even automobiles for a space to walk. The place where we used to enjoy strolling were given way either to bike lanes or to thoroughfares, or taken for the parking of automobiles that are ever increasing in the city.展开更多
The International Committee of Medical Journal Editors （ICMJE） believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themsel...The International Committee of Medical Journal Editors （ICMJE） believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk. In a growing consensus, many funders around the world - foundations, government agencies, and industry - now mandate data sharing. Here, we outline ICMJE＇s proposed requirements to help meet this obligation. We encourage feedback on the proposed requirements. Anyone can provide feedback at www. icmje.org by April 18, 2016.展开更多
In this special issue of Neuroscience Bulletin, the topics range over emerging techniques from the nanoscopic to the macroscopic scales. At the nanoscopic level, new ways to obtain images at the individual protein le...In this special issue of Neuroscience Bulletin, the topics range over emerging techniques from the nanoscopic to the macroscopic scales. At the nanoscopic level, new ways to obtain images at the individual protein level in synapses take the re- construction of synaptic architecture to a new level, while using chromophores to disable specific proteins at selected subcellular locations allows the assessment of their functional roles in such dynamic processes as growth-cone extension and cell division. The subtle influences of axonal chan- nels and receptors on neurotransmission are revealed by recording from the blebs induced by axotomy, while methods from cloning to chemical computation are being applied to dissecting the structural-functional rules by which ion channels operatet41.展开更多
Research on animal intestinal microbiota is one of the most cutting-edge topics in current zoological study.In addition to getting involved in host animals’physiological functions or behaviors(Aagaard et al.2014;Woti...Research on animal intestinal microbiota is one of the most cutting-edge topics in current zoological study.In addition to getting involved in host animals’physiological functions or behaviors(Aagaard et al.2014;Woting&Blaut 2016;Schretter et al.2018;Dang&Marsland 2019),the gut microbiome has been shown to influence the relation between the hosts and their neighboring species,which would eventually affect the host’s fitness and evolution positively or negatively(Douglas 2015;Sherwin et al.2019;Xu et al.2019;Groussin et al.2020;Jang&Kikuchi 2020).展开更多
The interplay between virus and host has been an everlasting evolutionary dance,with some advantageous outcomes,and some not so advantageous outcomes,such as cancer and autoimmunity.It has been well recognized that th...The interplay between virus and host has been an everlasting evolutionary dance,with some advantageous outcomes,and some not so advantageous outcomes,such as cancer and autoimmunity.It has been well recognized that the intertwinement of retroviral DNA regulatory elements,the remnants of retroviral infections,with the host genome is part of a lasting battle between pathogen replication/reinfection and the host defense.The high mutation rate of retro gene sequences has provided a means for viruses to escape suppression by the host,while also serving as a major driving force in host genome evolution.As an“unintended”consequence,the high mutation rate provides a vast retro-sequence repertoire for the host genome to domesticate to its own benefit,such as by regulating healthy biological processes,while also suppressing the harm.1e3 Endogenous retroviruses(ERV)with their functional open reading frames are rare post-infection legacies within the host genome that are inheritable through the germline.展开更多
文摘Developing global partnerships is an important focus for China’s diplomacy in the new era.1 President Xi Jinping proposed at the Central Conference on Work Relating to Foreign Affairs in November 2014,“We should make more friends while abiding by the principle of non-alignment and build a global network of partnerships.”
文摘A few years ago, after a vehement round of inner city renewal, I suddenly found many sidewalks in the city proper of Beijing became so narrow that pedestrians often had to compete with bikes and even automobiles for a space to walk. The place where we used to enjoy strolling were given way either to bike lanes or to thoroughfares, or taken for the parking of automobiles that are ever increasing in the city.
文摘The International Committee of Medical Journal Editors （ICMJE） believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk. In a growing consensus, many funders around the world - foundations, government agencies, and industry - now mandate data sharing. Here, we outline ICMJE＇s proposed requirements to help meet this obligation. We encourage feedback on the proposed requirements. Anyone can provide feedback at www. icmje.org by April 18, 2016.
文摘In this special issue of Neuroscience Bulletin, the topics range over emerging techniques from the nanoscopic to the macroscopic scales. At the nanoscopic level, new ways to obtain images at the individual protein level in synapses take the re- construction of synaptic architecture to a new level, while using chromophores to disable specific proteins at selected subcellular locations allows the assessment of their functional roles in such dynamic processes as growth-cone extension and cell division. The subtle influences of axonal chan- nels and receptors on neurotransmission are revealed by recording from the blebs induced by axotomy, while methods from cloning to chemical computation are being applied to dissecting the structural-functional rules by which ion channels operatet41.
文摘Research on animal intestinal microbiota is one of the most cutting-edge topics in current zoological study.In addition to getting involved in host animals’physiological functions or behaviors(Aagaard et al.2014;Woting&Blaut 2016;Schretter et al.2018;Dang&Marsland 2019),the gut microbiome has been shown to influence the relation between the hosts and their neighboring species,which would eventually affect the host’s fitness and evolution positively or negatively(Douglas 2015;Sherwin et al.2019;Xu et al.2019;Groussin et al.2020;Jang&Kikuchi 2020).
文摘The interplay between virus and host has been an everlasting evolutionary dance,with some advantageous outcomes,and some not so advantageous outcomes,such as cancer and autoimmunity.It has been well recognized that the intertwinement of retroviral DNA regulatory elements,the remnants of retroviral infections,with the host genome is part of a lasting battle between pathogen replication/reinfection and the host defense.The high mutation rate of retro gene sequences has provided a means for viruses to escape suppression by the host,while also serving as a major driving force in host genome evolution.As an“unintended”consequence,the high mutation rate provides a vast retro-sequence repertoire for the host genome to domesticate to its own benefit,such as by regulating healthy biological processes,while also suppressing the harm.1e3 Endogenous retroviruses(ERV)with their functional open reading frames are rare post-infection legacies within the host genome that are inheritable through the germline.
