Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work,we investigated the possibility of producing the^(64)Cu iso...Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work,we investigated the possibility of producing the^(64)Cu isotope through a^(65)Cu(γ,n) reaction using high-intensity γ-beams produced at the Extreme Light InfrastructureNuclear Physics facility(ELI-NP). The specific activity for^(64)Cu was obtained as a function of target geometry, irradiation time, and electron beam energy, which translates into γ-beam energy. Optimized conditions for the generation of^(64)Cu isotopes at the ELI-NP were discussed. We estimated that an achievable saturation specific activity is of the order of 1–2 m Ci/g for thin targets(radius 1–2 mm,thickness 1 cm) and for a γ-beam flux of 10^(11) s ~1. Based on these results, the ELI-NP could provide great potential for the production of some innovative radioisotopes of medical interest in sufficient quantities suitable for nuclear medicine research.展开更多
The thermonuclear^19F（p,α0）16O reaction rate in the temperature region 0.007–10 GK has been derived by re-evaluating the available experimental data, together with the low-energy theoretical R-matrix extrapolation...The thermonuclear^19F（p,α0）16O reaction rate in the temperature region 0.007–10 GK has been derived by re-evaluating the available experimental data, together with the low-energy theoretical R-matrix extrapolations.Our new rate deviates by up to about 30% compared to the previous results, although all rates are consistent within the uncertainties. At very low temperature（e.g. 0.01 GK） our reaction rate is about 20% lower than the most recently published rate, because of a difference in the low energy extrapolated S-factor and a more accurate estimate of the reduced mass used in the calculation of the reaction rate. At temperatures above ^1 GK, our rate is lower, for instance, by about 20% around 1.75 GK, because we have re-evaluated the previous data（Isoya et al., Nucl. Phys.7, 116（1958）） in a meticulous way. The present interpretation is supported by the direct experimental data. The uncertainties of the present evaluated rate are estimated to be about 20% in the temperature region below 0.2 GK,and are mainly caused by the lack of low-energy experimental data and the large uncertainties in the existing data.Asymptotic giant branch（AGB） stars evolve at temperatures below 0.2 GK, where the^19F（p,α）16O reaction may play a very important role. However, the current accuracy of the reaction rate is insufficient to help to describe, in a careful way, the fluorine over-abundances observed in AGB stars. Precise cross section（or S factor） data in the low energy region are therefore needed for astrophysical nucleosynthesis studies.展开更多
基金supported by Extreme Light Infrastructure-Nuclear Physics(ELI-NP)-Phase Ia project co-financed by the European Union through the European Regional Development Fund+1 种基金the National Natural Science Foundation of China(No.11405083)the Young Talent Project of the University of South China
文摘Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work,we investigated the possibility of producing the^(64)Cu isotope through a^(65)Cu(γ,n) reaction using high-intensity γ-beams produced at the Extreme Light InfrastructureNuclear Physics facility(ELI-NP). The specific activity for^(64)Cu was obtained as a function of target geometry, irradiation time, and electron beam energy, which translates into γ-beam energy. Optimized conditions for the generation of^(64)Cu isotopes at the ELI-NP were discussed. We estimated that an achievable saturation specific activity is of the order of 1–2 m Ci/g for thin targets(radius 1–2 mm,thickness 1 cm) and for a γ-beam flux of 10^(11) s ~1. Based on these results, the ELI-NP could provide great potential for the production of some innovative radioisotopes of medical interest in sufficient quantities suitable for nuclear medicine research.
基金Supported by National Natural Science Foundation of China(11490562,11490560,11675229)National Key Research and Development Program of China(2016YFA0400503)
文摘The thermonuclear^19F（p,α0）16O reaction rate in the temperature region 0.007–10 GK has been derived by re-evaluating the available experimental data, together with the low-energy theoretical R-matrix extrapolations.Our new rate deviates by up to about 30% compared to the previous results, although all rates are consistent within the uncertainties. At very low temperature（e.g. 0.01 GK） our reaction rate is about 20% lower than the most recently published rate, because of a difference in the low energy extrapolated S-factor and a more accurate estimate of the reduced mass used in the calculation of the reaction rate. At temperatures above ^1 GK, our rate is lower, for instance, by about 20% around 1.75 GK, because we have re-evaluated the previous data（Isoya et al., Nucl. Phys.7, 116（1958）） in a meticulous way. The present interpretation is supported by the direct experimental data. The uncertainties of the present evaluated rate are estimated to be about 20% in the temperature region below 0.2 GK,and are mainly caused by the lack of low-energy experimental data and the large uncertainties in the existing data.Asymptotic giant branch（AGB） stars evolve at temperatures below 0.2 GK, where the^19F（p,α）16O reaction may play a very important role. However, the current accuracy of the reaction rate is insufficient to help to describe, in a careful way, the fluorine over-abundances observed in AGB stars. Precise cross section（or S factor） data in the low energy region are therefore needed for astrophysical nucleosynthesis studies.
