Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects,but their mechanisms of action remain unknown.This study aimed to investigate the anti-inflammatory effects of preserved egg whi...Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects,but their mechanisms of action remain unknown.This study aimed to investigate the anti-inflammatory effects of preserved egg white(PEW)treatment on dextran sulfate sodium(DSS)-induced colitis in mice and the underlying mechanisms.The results showed that treatment with PEW in mice with DSS-induced colitis for 14 days effectively improved the clinical signs,inhibited the secretion and gene expression of pro-inflammatory cytokines,and reduced myeloperoxidase(MPO)activity and oxidative stress levels.In addition,western blotting results showed that PEW significantly suppressed DSS-induced phosphorylation levels of nuclear factor-kappa B(NF-κB)p65 and p38 mitogen-activated protein kinase(MAPK)in colon tissues of mice with colitis.PEW also enhanced the production of short-chain fatty acids(SCFAs)and modulated gut microbiota composition in mice with DSS-induced colitis,including increasing the relative abundance of beneficial bacteria Lachnospiraceae,Ruminococcaceae and Muribaculaceae,and reducing the relative abundance of harmful bacteria Proteobacteria.Taken together,our study demonstrated that preserved egg white could alleviate DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition.展开更多
For the characterization of the behaviors of a metal material in events like expanding warheads, it is necessary to know its strength and ductility at high strain rates, around 104e105/s. The flyer plate impact testin...For the characterization of the behaviors of a metal material in events like expanding warheads, it is necessary to know its strength and ductility at high strain rates, around 104e105/s. The flyer plate impact testing produces the uniform stress and strain rates but the testing is expensive. The Taylor test is relatively inexpensive but produces non-uniform stress and strain fields, and the results are not so easily inferred for material modeling. In the split-Hopkinson bar(SHB), which may be used in compression, tension and torsion testing, the strain rates never exceeds 103/s. In the present work, we use the expanding ring test where the strain rate is 104e105/s. A streak camera is used to examine the expanding ring velocity, and a water tank is used to collect the fragments. The experimental results are compared with the numerical simulations using the hydrocodes AUTODYN, IMPETUS Afea and a regularized smooth particle(RSPH) software. The number of fragments increases with the increase in the expansion velocity of the rings. The number of fragments is similar to the experimental results. The RSPH software shows much the same results as the AUTODYN where the Lagrangian solver is used for the ring. The IMPETUS Afea solver shows a somewhat different fragmentation characteristic due to the node splitting algorithm that induces pronounced tensile splitting.展开更多
Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its...Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well.展开更多
The depth of penetration(DOP)method is a well-known ballistic test method for characterisation and ranking of ceramic armour materials.The ceramic tile is bonded to a backing material of semi-infinite thickness,and th...The depth of penetration(DOP)method is a well-known ballistic test method for characterisation and ranking of ceramic armour materials.The ceramic tile is bonded to a backing material of semi-infinite thickness,and the penetration depth of the projectile gives a measure of the performance of the ceramic.There is,however,an inherent variability in the results from this test method.In this work,the accuracy and the variability of the DOP method has been investigated in a round robin exercise.Six ballistic test centres took part in the exercise.A test protocol was developed,in which the threat type(projectile and impact conditions)and a procedure on how to prepare the targets were specified.The targets consisted of alumina tiles of two different thicknesses that were bonded to polycarbonate backing cubes.Two different 7.62 mm armour piercing projectiles were employed;one with a hard steel core and one with a tungsten carbide core.The projectiles and the other materials all came from single material batches in order to avoid batch-to-batch variations in material properties.These materials were distributed between the ballistic test centres.The test results of the different ballistic test facilities were collected and compared.There was not a lot of variation between the average DOP values obtained at each laboratory,but the variation in penetration depth between shots was high.The consequence of this variation may be less confidence in the test results,and a statistical method was used to evaluate the required number of tests that are sufficient to obtain an average result with high confidence.In most cases,the required number of tests is much higher than what is practically feasible.This work was conducted as part of the European Defence Agency-project CERAMBALL.展开更多
As ultrafast laser technology advances towards ever higher peak and average powers,generating sub-50 fs pulses from laser architectures that exhibit best power-scaling capabilities remains a major challenge.Here,we pr...As ultrafast laser technology advances towards ever higher peak and average powers,generating sub-50 fs pulses from laser architectures that exhibit best power-scaling capabilities remains a major challenge.Here,we present a very compact and highly robust method to compress 1.24 ps pulses to 39fs by means of only a single spectral broadening stage which neither requires vacuum parts nor custom-made optics.Our approach is based on the hybridization of the multiplate continuum and.the multipass cell spectral broadening techniques.Their combination leads to significantly higher spectral broadening factors in bulk material than what has been reported from either method alone.Moreover,our approach efficiently suppresses adverse features of single-pass bulk spectral broadening.We use a burst-mode Yb:YAG laser emitting pulses with 80 MW peak power that are enhanced to more than 1 GW after postcompression.With only 0.19%rms pulse-to-pulse energy fluctuations,the technique exhibits excellent stability.Furthermore,we have measured state-of-the-art spectral-spatial homogeneity and good beam quality of M^(2)=1.2 up to a spectral broadening factor of 30.Due to the method's simplicity,compactness,and scalability,it is highly attractive for turning a picosecond laser into an ultrafast light source that generates pulses of only a few tens of femtoseconds duration.展开更多
基金financially supported by the Chinese National Natural Science Funds (31772043)the Fundamental Research Funds for the Central Universities (2662018JC021)
文摘Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects,but their mechanisms of action remain unknown.This study aimed to investigate the anti-inflammatory effects of preserved egg white(PEW)treatment on dextran sulfate sodium(DSS)-induced colitis in mice and the underlying mechanisms.The results showed that treatment with PEW in mice with DSS-induced colitis for 14 days effectively improved the clinical signs,inhibited the secretion and gene expression of pro-inflammatory cytokines,and reduced myeloperoxidase(MPO)activity and oxidative stress levels.In addition,western blotting results showed that PEW significantly suppressed DSS-induced phosphorylation levels of nuclear factor-kappa B(NF-κB)p65 and p38 mitogen-activated protein kinase(MAPK)in colon tissues of mice with colitis.PEW also enhanced the production of short-chain fatty acids(SCFAs)and modulated gut microbiota composition in mice with DSS-induced colitis,including increasing the relative abundance of beneficial bacteria Lachnospiraceae,Ruminococcaceae and Muribaculaceae,and reducing the relative abundance of harmful bacteria Proteobacteria.Taken together,our study demonstrated that preserved egg white could alleviate DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition.
文摘For the characterization of the behaviors of a metal material in events like expanding warheads, it is necessary to know its strength and ductility at high strain rates, around 104e105/s. The flyer plate impact testing produces the uniform stress and strain rates but the testing is expensive. The Taylor test is relatively inexpensive but produces non-uniform stress and strain fields, and the results are not so easily inferred for material modeling. In the split-Hopkinson bar(SHB), which may be used in compression, tension and torsion testing, the strain rates never exceeds 103/s. In the present work, we use the expanding ring test where the strain rate is 104e105/s. A streak camera is used to examine the expanding ring velocity, and a water tank is used to collect the fragments. The experimental results are compared with the numerical simulations using the hydrocodes AUTODYN, IMPETUS Afea and a regularized smooth particle(RSPH) software. The number of fragments increases with the increase in the expansion velocity of the rings. The number of fragments is similar to the experimental results. The RSPH software shows much the same results as the AUTODYN where the Lagrangian solver is used for the ring. The IMPETUS Afea solver shows a somewhat different fragmentation characteristic due to the node splitting algorithm that induces pronounced tensile splitting.
基金supported by the Margot Marsh Biodiversity FoundationPrimate Action Fund+1 种基金Helmsley Charitable TrustCritical Ecosystem Partnership Fund。
文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well.
基金conducted as part of the European Defence Agency-project CERAMBALL,contract number B 1091 GEM1 GP
文摘The depth of penetration(DOP)method is a well-known ballistic test method for characterisation and ranking of ceramic armour materials.The ceramic tile is bonded to a backing material of semi-infinite thickness,and the penetration depth of the projectile gives a measure of the performance of the ceramic.There is,however,an inherent variability in the results from this test method.In this work,the accuracy and the variability of the DOP method has been investigated in a round robin exercise.Six ballistic test centres took part in the exercise.A test protocol was developed,in which the threat type(projectile and impact conditions)and a procedure on how to prepare the targets were specified.The targets consisted of alumina tiles of two different thicknesses that were bonded to polycarbonate backing cubes.Two different 7.62 mm armour piercing projectiles were employed;one with a hard steel core and one with a tungsten carbide core.The projectiles and the other materials all came from single material batches in order to avoid batch-to-batch variations in material properties.These materials were distributed between the ballistic test centres.The test results of the different ballistic test facilities were collected and compared.There was not a lot of variation between the average DOP values obtained at each laboratory,but the variation in penetration depth between shots was high.The consequence of this variation may be less confidence in the test results,and a statistical method was used to evaluate the required number of tests that are sufficient to obtain an average result with high confidence.In most cases,the required number of tests is much higher than what is practically feasible.This work was conducted as part of the European Defence Agency-project CERAMBALL.
文摘As ultrafast laser technology advances towards ever higher peak and average powers,generating sub-50 fs pulses from laser architectures that exhibit best power-scaling capabilities remains a major challenge.Here,we present a very compact and highly robust method to compress 1.24 ps pulses to 39fs by means of only a single spectral broadening stage which neither requires vacuum parts nor custom-made optics.Our approach is based on the hybridization of the multiplate continuum and.the multipass cell spectral broadening techniques.Their combination leads to significantly higher spectral broadening factors in bulk material than what has been reported from either method alone.Moreover,our approach efficiently suppresses adverse features of single-pass bulk spectral broadening.We use a burst-mode Yb:YAG laser emitting pulses with 80 MW peak power that are enhanced to more than 1 GW after postcompression.With only 0.19%rms pulse-to-pulse energy fluctuations,the technique exhibits excellent stability.Furthermore,we have measured state-of-the-art spectral-spatial homogeneity and good beam quality of M^(2)=1.2 up to a spectral broadening factor of 30.Due to the method's simplicity,compactness,and scalability,it is highly attractive for turning a picosecond laser into an ultrafast light source that generates pulses of only a few tens of femtoseconds duration.
