MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the ...MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the expression of the mRNA.More recently,it has become apparent that dhanges in the miR-153 axpression lead to invasion,metastasis,angiogenesis and various types of tumor progression.This review summarizes the connection between dysrgulation of miR-153 and various typas of cancer progression.miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the ancer cell and also show synergistic activity with anticancer drugs.In addition to this,the oncogenic bchavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.展开更多
Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nano...Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nanovesicle technology such as exosomes, proteomic and genomics studies could further contribute to better identification of anomalous protein and networks which could act as potential targets for biomarker and immunotherapy development. This review provides an overview of the circulating and non-circulating biomarkers with the aim of addressing the current challenges and potential biomarkers that could lead to early ovarian cancer diagnosis and better management. By means of this review we also lay a hypothesis that characterization of exosomal protein, nucleic acid content from body fluids (serum, plasma, urine, etc.) can decode the secret of disease and potentially improve diagnostic sensitivity which could further lead to more effective screening and early detection of the disease.展开更多
The production of biohydrogen from biological processes is cleaner and more sustainable than that of fossil fuel-based hydrogen.The drive for cleaner and sustainable energy sources is an important facet of the bioecon...The production of biohydrogen from biological processes is cleaner and more sustainable than that of fossil fuel-based hydrogen.The drive for cleaner and sustainable energy sources is an important facet of the bioeconomy.Based on these findings,this paper aimed to examine the significance and impact of biohydrogen on the bioeconomy.These bioprocessing strategies are primarily biophotolysis,fermentation and bio-electrolytic systems.Considering that biological processes are slow compared to other thermochemical production processes,production volumes cannot match that of the latter.The inherently slow nature of biochemical reactions taking place in living organisms is a challenge that puts biohydrogen at a disadvantage.Biological processes are also very sensitive to temperature and pH,thereby requiring more intricate process monitoring and control.To obtain equivalent volumes of biohydrogen compared to production strategies,larger and more intricate facilities would be needed,implying more cost implications.It is surmised that biohydrogen will continue to play an important role in the drive for a sustainable bioeconomy despite the current challenges it faces.展开更多
文摘MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the expression of the mRNA.More recently,it has become apparent that dhanges in the miR-153 axpression lead to invasion,metastasis,angiogenesis and various types of tumor progression.This review summarizes the connection between dysrgulation of miR-153 and various typas of cancer progression.miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the ancer cell and also show synergistic activity with anticancer drugs.In addition to this,the oncogenic bchavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.
文摘Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nanovesicle technology such as exosomes, proteomic and genomics studies could further contribute to better identification of anomalous protein and networks which could act as potential targets for biomarker and immunotherapy development. This review provides an overview of the circulating and non-circulating biomarkers with the aim of addressing the current challenges and potential biomarkers that could lead to early ovarian cancer diagnosis and better management. By means of this review we also lay a hypothesis that characterization of exosomal protein, nucleic acid content from body fluids (serum, plasma, urine, etc.) can decode the secret of disease and potentially improve diagnostic sensitivity which could further lead to more effective screening and early detection of the disease.
文摘The production of biohydrogen from biological processes is cleaner and more sustainable than that of fossil fuel-based hydrogen.The drive for cleaner and sustainable energy sources is an important facet of the bioeconomy.Based on these findings,this paper aimed to examine the significance and impact of biohydrogen on the bioeconomy.These bioprocessing strategies are primarily biophotolysis,fermentation and bio-electrolytic systems.Considering that biological processes are slow compared to other thermochemical production processes,production volumes cannot match that of the latter.The inherently slow nature of biochemical reactions taking place in living organisms is a challenge that puts biohydrogen at a disadvantage.Biological processes are also very sensitive to temperature and pH,thereby requiring more intricate process monitoring and control.To obtain equivalent volumes of biohydrogen compared to production strategies,larger and more intricate facilities would be needed,implying more cost implications.It is surmised that biohydrogen will continue to play an important role in the drive for a sustainable bioeconomy despite the current challenges it faces.
