Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, ^1H NMR and MS. Cell growth inhibitory effects ...Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, ^1H NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group.展开更多
Coordination-driven self-assembly strategy has demonstrated the efficiency and versatility to construct well-ordered supramolecular coordination complexes （SCCs） such as discrete metallacycles and metallacages. In r...Coordination-driven self-assembly strategy has demonstrated the efficiency and versatility to construct well-ordered supramolecular coordination complexes （SCCs） such as discrete metallacycles and metallacages. In recent years, it has aroused tremendous interest to build more complexed self-assembled structures via the implementation of additional non-covalent recognition motifs on the SCCs platform. In this work, we have successfully attained this objective, with the elaborate manipulation of non-interfering pyridine-Pt2＋ and molecular tweezer/guest complexation in a hierarchical self-assembly manner. The resulting SCCs-based linear supramolecular polymers exhibit intriguing NIR-emissive behaviors, primarily attributed to the presence of intermolecular Pt（II）-Pt（II） metal-metal interactions in the non-covalent tweezering structure. Hence, supramolecular engineering of multiple non-covalent interactions offers a feasible avenue toward functional materials with tailored properties.展开更多
基金Natural Science Foundation of Liaoning Province of China (No.20042009)Science and Technology Foundation of Shenyang City of China(No.20050785)
文摘Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, ^1H NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group.
基金financially supported by the National Natural Science Foundation of China(No.21674106)the Fundamental Research Funds for the Central Universities(No.WK3450000001)CAS Youth Innovation Promotion Association(No.2015365)
文摘Coordination-driven self-assembly strategy has demonstrated the efficiency and versatility to construct well-ordered supramolecular coordination complexes （SCCs） such as discrete metallacycles and metallacages. In recent years, it has aroused tremendous interest to build more complexed self-assembled structures via the implementation of additional non-covalent recognition motifs on the SCCs platform. In this work, we have successfully attained this objective, with the elaborate manipulation of non-interfering pyridine-Pt2＋ and molecular tweezer/guest complexation in a hierarchical self-assembly manner. The resulting SCCs-based linear supramolecular polymers exhibit intriguing NIR-emissive behaviors, primarily attributed to the presence of intermolecular Pt（II）-Pt（II） metal-metal interactions in the non-covalent tweezering structure. Hence, supramolecular engineering of multiple non-covalent interactions offers a feasible avenue toward functional materials with tailored properties.
